Browse our TRPV4 Proteins (TRPV4)

Full name:
Transient Receptor Potential Cation Channel, Subfamily V, Member 4 Proteins (TRPV4)
On www.antibodies-online.com are 6 Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) Proteins from 1 different suppliers available. Additionally we are shipping TRPV4 Antibodies (103) and TRPV4 Kits (2) and many more products for this protein. A total of 125 TRPV4 products are currently listed.
Synonyms:
0610033B08Rik, CMT2C, HMSN2C, Otrpc4, SMAL, SPSMA, SSQTL1, Trp12, VR-OAC, VRL-2, VRL2, Vroac, wu:fp52e02
list all proteins Gene Name GeneID UniProt
TRPV4 59341 Q9HBA0
TRPV4 63873 Q9EPK8
Rat TRPV4 TRPV4 66026 Q9ERZ8

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TRPV4 Proteins (TRPV4) by Origin

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More Proteins for TRPV4 Interaction Partners

Zebrafish Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) interaction partners

  1. TRPP2 and TRPV4 are mechanosensitive channels in the endocardium.Oscillatory flow modulates mechanosensitive klf2a expression through trpv4 and trpp2 during heart valve development.

  2. TRPP2 utilizes TRPV4 to form a mechano- and thermosensitive molecular sensor in the cilium.

  3. Age-dependence of heat-activated seizure susceptibility mimicks the mRNA expression of TRPV4 and glutamate (show GRIN2A Proteins) receptors.

  4. TRPV4 present in all sensory organs of adult zebrafish.

  5. Study reports cloning of a zebrafish trpv4 cDNA and assaying its expression during embryogenesis; trpv4 is expressed as maternal mRNA in 4-cell embryos and later zygotic expression is first observed in the forming notochord at the one somite stage.

  6. OS-9 (show OS9 Proteins) regulates the secretory transport of TRPV4 and appears to protect TRPV4 subunits from the precocious ubiquitination and ER-associated degradation.

Human Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) interaction partners

  1. A novel causative variant in the TRPV4 identified in a fetus with metatropic dysplasia in third trimester of pregnancy.

  2. reduced tissue osmolarity, likely following proteoglycan (show Vcan Proteins) degradation, can increase TRPV4 signalling and enhance pro-inflammatory cytokine production.

  3. A novel TRPV4 mutation implicating TRPV4 and altered calcium homeostasis in the pathogenesis of osteonecrosis was identified while reinforcing the importance of TRPV4 in bone diseases and vascular endothelium.

  4. both TRPV2 and TRPV4 are involved in migration of human cardiac c-kit(+) progenitor cells.

  5. Data show that arylalkymine N-acetyltransferase (AANAT (show AANAT Proteins)) levels and melatonin synthesis change after transient receptor potential channel 4 (show TRPC4 Proteins) (TRPV4 channel) stimulation in ciliary body epithelial cells .

  6. TRPV4-induced calcium mobilization and inflammatory responses were enhanced in cystic fibrosis transmembrane conductance regulator (show CFTR Proteins)-deficient cellular models.

  7. direct electrophysiological and pharmacological evidence for both TRPV4 and L-type Ca2 (show CA2 Proteins)+ conductances, as well as a tetraethylammonium (TEA)- and paxilline-sensitive K+ conductance in human pulmonary fibroblasts.

  8. We demonstrate that pharmacological activation or inhibition of TRPV4 regulates Ca(2 (show CA2 Proteins)+)-wave propagation from head to tail. Such findings may have wide application in male fertility-infertility, contraception and conservation of endangered species as well.

  9. These results confirm the function of TRPV4 in human cultured adipocytes and its regulation by insulin (show INS Proteins).

  10. Helicobacter pylori infection-dependent DNA methylation (show HELLS Proteins) suppressed TRPV4 expression in human gastric epithelia, suggesting that TRPV4 methylation may be involved in Helicobacter pylori-associated dyspepsia.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) interaction partners

  1. Our observations thus suggest that the TRPV4 ion channel is involved in mechanotransduction in juxtaglomerular cells.

  2. TRPV4-knockout mice were protected from D. farinae-induced airway remodeling. TRPV4 modulated matrix remodeling in the lung via 2 distinct but dependent pathways: one enhances matrix deposition by fibrotic gene activation, whereas the other slows down matrix degradation by increased plasminogen activator inhibitor 1 (show SERPINE1 Proteins).

  3. Study found that hypotonicity in the portal circulation, probably sensed by TRPV4 channels, triggers the osmopressor response and intact renal nerves are needed for the full response.

  4. Altogether, these data identify a novel reciprocal functional link between TRPV4 activation and TGFbeta1 (show TGFB1 Proteins) signals regulating dermal myofibroblast differentiation. These findings suggest that therapeutic inhibition of TRPV4 activity may provide a targeted approach to the treatment of scleroderma.

  5. Dynamic coupling between TRPV4 and Ca(2 (show CA2 Proteins)+)-activated SK1 (show SPHK1 Proteins)/3 and IK1 (show KCNN4 Proteins) K(+) channels plays a critical role in regulating the K(+)-secretory BK channel KCNMA1 (show KCNMA1 Proteins) in kidney collecting duct cells.

  6. TRPV4 channels are important for bladder afferent signaling. TRPV4 -/- mice bladders generate more noxious sensory output, which is predominantly mediated through TRPV1 (show TRPV1 Proteins) expressing high threshold nerve fibers.

  7. TRPV4 does not play a major role in the kidney or is efficiently compensated when deleted. TRPV4 is critical for the release of vasopressin (show AVP Proteins), the sensation of thirst, and the central osmoregulation.

  8. These results suggest that the Na(+) signal generated in Nax (show SCN7A Proteins)-positive glial cells leads to the activation of TRPV4-positive neurons in sCVOs to stimulate water intake by using EETs as gliotransmitters.

  9. TRPV4 plays a critical role in the transduction of mechanical forces and gets activated by cell swelling and surface expansion.

  10. The absence of TRPV4-ATP-mediated effects on C-fibers indicates a distinct neurobiology for this ion channel and implicates TRPV4 as a novel therapeutic target for neuronal hyperresponsiveness in the airways and symptoms, such as cough.

Pig (Porcine) Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) interaction partners

  1. Data indicate a physiologic function of transient receptor potential vanilloid 4 (TRPV4) in the regulation of blood-cerebrospinal fluid barrier (BCSFB) permeability.

  2. Hyposmotic shock-induced TRPV4 channel activation regulates hemichannel-mediated ATP release and Na-K-ATPase (show ATP1A1 Proteins) activity in lens epithelium.

  3. The large amounts of transported calcium and the short signaling ways suggest a potentially important role of TRPV4 in many physiological processes.

  4. TRPV4 is present in articular chondrocytes in swine, and chondrocyte response to hypo-osmotic stress is mediated by this channel, which involves both an extracellular Ca(2 (show CA2 Proteins)+) and intracellular Ca(2 (show CA2 Proteins)+) release.

Cow (Bovine) Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) interaction partners

  1. reduced tissue osmolarity, likely following proteoglycan (show Vcan Proteins) degradation, can increase TRPV4 signalling and enhance pro-inflammatory cytokine production.

  2. TRPV4 channels activity in bovine articular chondrocytes are regulated by obesity-associated mediators.

  3. TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling.

TRPV4 Protein Profile

Protein Summary

This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with TRPV4

  • transient receptor potential cation channel, subfamily V, member 4 (trpv4)
  • transient receptor potential cation channel, subfamily V, member 4 (TRPV4)
  • transient receptor potential cation channel, subfamily V, member 4 (LOC100220808)
  • transient receptor potential cation channel, subfamily V, member 4 (Trpv4)
  • 0610033B08Rik protein
  • CMT2C protein
  • HMSN2C protein
  • Otrpc4 protein
  • SMAL protein
  • SPSMA protein
  • SSQTL1 protein
  • Trp12 protein
  • VR-OAC protein
  • VRL-2 protein
  • VRL2 protein
  • Vroac protein
  • wu:fp52e02 protein

Protein level used designations for TRPV4

transient receptor potential cation channel subfamily V member 4 , transient receptor potential cation channel, subfamily V, member 4 , transient receptor potential cation channel subfamily V member 4-like , OSM9-like transient receptor potential channel 4 , osm-9-like TRP channel 4 , osmosensitive transient receptor potential channel 4 , transient receptor potential protein 12 , vanilloid receptor-like channel 2 , vanilloid receptor-related osmotically activated channel , vanilloid receptor-like protein 2 , vanilloid receptor-related osmotically-activated channel , VR-OAC , transient receptor potential cation channel, subfamily 5, member 4 , vanilloid receptor-related osmotically activated channel (Vroac) , vanilloid receptor-related osmotically activated channel protein

GENE ID SPECIES
557850 Danio rerio
709605 Macaca mulatta
100458589 Pongo abelii
100472561 Ailuropoda melanoleuca
100539676 Meleagris gallopavo
100590720 Nomascus leucogenys
100220808 Taeniopygia guttata
59341 Homo sapiens
63873 Mus musculus
66026 Rattus norvegicus
395427 Gallus gallus
486308 Canis lupus familiaris
100126845 Sus scrofa
540259 Bos taurus
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