Necrosis Inhibitor, Necrox-2

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Application
Blocking Reagent (BR), Inhibition Assay (InhA)
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Purpose A necrosis inhibitor
Characteristics A cell-permeable necrosis inhibitor that displays antioxidant property. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1 µM NecroX-2 prevented ca. 50 % cell death in H9C2 cells exposed to 400 µM t-BuOOH for 2 hours). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro.
Purity ≥ 95 % by HPLC
Chemical Name [5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(1-methanesulfonyl-piperidin-4-yl)-amine
Formula C₂₅H₃₂N₄O₄S₂
Permeability Cell-permeable
Solubility DMSO (> 10 mg/mL)
Molecular Weight 516.67 g/mol
Restrictions For Research Use only
Format Solid
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 24 months
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Product cited in: Wang, Xiao, Ling, Meng, Wu, Yang, Zou: "BNIP3 upregulation by ERK and JNK mediates cadmium-induced necrosis in neuronal cells." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 140, Issue 2, pp. 393-402, 2014 (PubMed).