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Z-YVAD-FMK (Caspase-1 Inhibitor)

Details for Product No. ABIN412072, Supplier: Log in to see
Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
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Purpose A caspase-4 inhibitor
Sequence Z-Tyr-Val-Ala-Asp(OMe)-FMK
Characteristics A synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Purity Single spot by TLC
Chemical Name Z-YVAD fluoromethylketone
Formula C₃₁H₃₉FN₄O₉
Permeability Cell-permeable
Solubility DMSO (20 mM)
Molecular Weight 630.7 Da
Application Notes We recommend using 2-10 µM for inhibiting caspase activity in cell culture.
The optimal doses may vary for different cells and culture conditions.
Restrictions For Research Use only
Format Lyophilized
Handling Advice Protect from light and moisture.
Storage -20 °C
Expiry Date 12 months
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 image for Z-YVAD-FMK (Caspase-1 Inhibitor) (ABIN412072) Z-YVAD-FMK (Caspase-1 Inhibitor)
Product cited in: Zhou, Shah, Yang, Zhang, Zhou, Zhao: "Virulent Mycobacterium bovis Beijing Strain Activates the NLRP7 Inflammasome in THP-1 Macrophages." in: PLoS ONE, Vol. 11, Issue 4, pp. e0152853, 2016

Burm, Zuiderwijk-Sick, t Jong, van der Putten, Veth, Kondova, Bajramovic: "Inflammasome-induced IL-1β secretion in microglia is characterized by delayed kinetics and is only partially dependent on inflammatory caspases." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 2, pp. 678-87, 2015

Kim, Amarnani, Gnanaguru, Tseng, Vavvas, DAmore: "Tamoxifen toxicity in cultured retinal pigment epithelial cells is mediated by concurrent regulated cell death mechanisms." in: Investigative ophthalmology & visual science, Vol. 55, Issue 8, pp. 4747-58, 2014

Tseng, Thein, Kinnunen, Lashkari, Gregory, DAmore, Ksander: "NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration." in: Investigative ophthalmology & visual science, Vol. 54, Issue 1, pp. 110-20, 2013

Lee, Hwang, Palaniyar, Grinstein, Philpott, Hu: "Activation of P2X(7) receptor by ATP plays an important role in regulating inflammatory responses during acute viral infection." in: PLoS ONE, Vol. 7, Issue 4, pp. e35812, 2012

Chang, Lin, Wu, Kuo, Wu, Shieh, Gean, Chen, Chen, Wu, Tai, Tseng: "Mechanisms underlying benzyl alcohol cytotoxicity (triamcinolone acetonide preservative) in human retinal pigment epithelial cells." in: Investigative ophthalmology & visual science, Vol. 52, Issue 7, pp. 4214-22, 2011

Ariazi, Cunliffe, Lewis-Wambi, Slifker, Willis, Ramos, Tapia, Kim, Yerrum, Sharma, Nicolas, Balagurunathan, Ross, Jordan: "Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 47, pp. 18879-86, 2011

Shao: "Understanding the mechanisms of human tubal ectopic pregnancies: new evidence from knockout mouse models." in: Human reproduction (Oxford, England), Vol. 25, Issue 3, pp. 584-7, 2010

Wei, Kadia, Tong, Zhang, Jia, Yang, Hu, Tambaro, Viallet, OBrien, Garcia-Manero: "The combination of a histone deacetylase inhibitor with the Bcl-2 homology domain-3 mimetic GX15-070 has synergistic antileukemia activity by activating both apoptosis and autophagy." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 15, pp. 3923-32, 2010