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Z-DEVD-FMK (Caspase-3 Inhibitor)

Details for Product No. ABIN412077, Supplier: Log in to see
Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
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Purpose A caspase-3 inhibitor
Sequence Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK
Characteristics A synthetic peptide that irreversibly inhibits activity of DEVD-dependent caspases (e.g., caspase-3 and caspase-7) and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Purity Single spot by TLC
Chemical Name Z-DEVD-fluoromethylketone
Formula C₃₀H₄₁FN₄O₁₂
Permeability Cell-permeable
Solubility DMSO (20 mM)
Molecular Weight 668.7 Da
Application Notes We recommend using 2-10 µM for inhibiting caspase activity in cell culture.
The optimal doses may vary for different cells and culture conditions.
Restrictions For Research Use only
Format Lyophilized
Handling Advice Protect from light and moisture.
Storage -20 °C
Expiry Date 12 months
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 image for Z-DEVD-FMK (Caspase-3 Inhibitor) (ABIN412077) Z-DEVD-FMK (Caspase-3 Inhibitor)
Product cited in: Moon, Kim, Gao, Quan, Qin, Osorio, Rosas, Wu, Tesfaigzi, Jin: "CCN1 secretion and cleavage regulate the lung epithelial cell functions after cigarette smoke." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 307, Issue 4, pp. L326-37, 2014

Kim, Amarnani, Gnanaguru, Tseng, Vavvas, DAmore: "Tamoxifen toxicity in cultured retinal pigment epithelial cells is mediated by concurrent regulated cell death mechanisms." in: Investigative ophthalmology & visual science, Vol. 55, Issue 8, pp. 4747-58, 2014

Pianu, Lefort, Thuiliere, Tabourier, Bartolini: "The Aβ₁₋₄₂ peptide regulates microtubule stability independently of tau." in: Journal of cell science, Vol. 127, Issue Pt 5, pp. 1117-27, 2014

Heinhuis, Koenders, van den Berg, Netea, Dinarello, Joosten: "Interleukin 32 (IL-32) contains a typical ?-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1." in: The Journal of biological chemistry, Vol. 287, Issue 8, pp. 5733-43, 2012

Du, Yamamoto, Ueda, Suzuki, Tano, Kamei: "Activated protein C rescues the retina from ischemia-induced cell death." in: Investigative ophthalmology & visual science, Vol. 52, Issue 2, pp. 987-93, 2011

Ariazi, Cunliffe, Lewis-Wambi, Slifker, Willis, Ramos, Tapia, Kim, Yerrum, Sharma, Nicolas, Balagurunathan, Ross, Jordan: "Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 47, pp. 18879-86, 2011

Hara, Senga, Biswas, Hasegawa, Ito, Hyodo, Hirooka, Niwa, Goto, Hamaguchi: "Recovery of anoikis in Src-transformed cells and human breast carcinoma cells by restoration of the SIRP α1/SHP-2 signaling system." in: Cancer research, Vol. 71, Issue 4, pp. 1229-34, 2011

Verma, Jain, Caseltine, Rennels, Bhattacharya, Markiewski, Rawat, Neethling, Bickel, Weidanz: "TCR mimic monoclonal antibodies induce apoptosis of tumor cells via immune effector-independent mechanisms." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 5, pp. 3265-76, 2011

Vogt, Harmata, Coulombe, Bross, Blackstone: "Causes and consequences of stolon regression in a colonial hydroid." in: The Journal of experimental biology, Vol. 214, Issue Pt 19, pp. 3197-205, 2011

Abdul-Ghani, Dufort, Stiles, De Repentigny, Kothary, Megeney: "Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals." in: Molecular and cellular biology, Vol. 31, Issue 1, pp. 163-78, 2010

Zhong, Carney, Boyan, Schwartz: "17β-Estradiol regulates rat growth plate chondrocyte apoptosis through a mitochondrial pathway not involving nitric oxide or MAPKs." in: Endocrinology, Vol. 152, Issue 1, pp. 82-92, 2010

Hirata, Osuga, Takamura, Kodama, Hirota, Koga, Yoshino, Harada, Takemura, Yano, Taketani: "Recruitment of CCR6-expressing Th17 cells by CCL 20 secreted from IL-1 beta-, TNF-alpha-, and IL-17A-stimulated endometriotic stromal cells." in: Endocrinology, Vol. 151, Issue 11, pp. 5468-76, 2010

Cunningham, Giuffrida, Roberts: "Androgens induce dopaminergic neurotoxicity via caspase-3-dependent activation of protein kinase Cdelta." in: Endocrinology, Vol. 150, Issue 12, pp. 5539-48, 2009