Details for Product No. ABIN412271, Supplier: Log in to see
Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
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Purpose A GSK-3 inhibitor
Characteristics A potent, selective, reversible and ATP-competitive inhibitor of GSK-3alpha/beta (IC50 = 5 nM). Under a feeder-free condition, BIO maintains embryonic stem cells (hESCs) in the undifferentiated state.
Purity ≥ 98 %
Chemical Name (2Z, 3E)-6'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one
Formula C₁₆H₁₀BrN₃O₂
Permeability Cell-permeable
Solubility DMSO (10 mg/ml) or EtOH (0.5 mg/ml)
Molecular Weight 356.17 g/mol
CAS-No 667463-62-9
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
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 image for BIO (ABIN412271) BIO
Product cited in: Zhou, Zhang, Wu, Ghai, Field: "Phosphorylation of the cytoskeletal protein CAP1 controls its association with cofilin and actin." in: Journal of cell science, Vol. 127, Issue 23, pp. 5052-65, 2014 (PubMed).