SCD1 Inhibitor

Details for Product No. ABIN412321, Supplier: Log in to see
Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
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Purpose A SCD1(stearoyl-CoA desaturase 1 inhibitor
Characteristics A potent and selective inhibitor of SCD1(stearoyl-CoA desaturase 1) (In vitro: IC₅₀ = 37 nM for hSCD1, <4 nM for mSCD1). Also exhibited in vivo efficacy with dose-dependent desaturation index lowering effect. SCD1 inhibition resulted in alterations in macrophage membrane lipid composition and marked hypersensitivity to toll-like receptor 4 agonists.
Purity ≥ 95 % by HPLC
Chemical Name 4-(2-Chlorophenoxy)-N-(3-(3-methylcarbamoyl)phenyl)piperidine-1-carboxamide
Formula C₂₀H₂₂ClN₃O₃
Permeability Cell-permeable
Solubility DMSO (~ 180 mg/ml)
Molecular Weight 387.86 g/mol
CAS-No 1032229-33-6
Research Area Kinases/Phosphatases
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
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Product cited in: Iwasaki, Suganami, Hachiya, Shirakawa, Kim-Saijo, Tanaka, Hamaguchi, Takai-Igarashi, Nakai, Miyamoto, Ogawa: "Activating transcription factor 4 links metabolic stress to interleukin-6 expression in macrophages." in: Diabetes, Vol. 63, Issue 1, pp. 152-61, 2013 (PubMed).