Dexamethasone (10 mM)

Details for Product No. ABIN412363, Supplier: Log in to see
Functional Studies (Func), Enzyme Activity Assay (EAA), Inhibition Assay (InhA)
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Characteristics PubChem CID: 5743
Purity > 99 % by TLC
Chemical Name 9α-Fluoro-16α-methylprednisolone, Prednisolone F, (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione
Formula C₂₂H₂₉FO₅
Permeability Cell-permeable
Solubility Solubility: Soluble in ethanol (25 mg/mL)
Molecular Weight 392.46 g/mol
CAS-No 50-02-2

An anti-inflammatory glucocorticoid. Inhibits the expression of the inducible but not the constitutive nitric oxide synthase in vascular endothelial cells (IC50 = 5 nM). Enhances active cation transport in aortic smooth muscle cells by stimulating the Na+-K+ pump. Has anti-inflammatory and anti-rheumatic properties. Induces apoptosis in human thymocytes. In general, 500-1000 nM of dexamethasone is sufficient to induce apoptosis following a 6-hour incubation at 37 °C

Restrictions For Research Use only
Format Liquid
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 6 months
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 image for Dexamethasone (10 mM) (ABIN412363) Dexamethasone (10 mM)
Product cited in: Kudrin, Scott, Martin, Chung, Donn, McMaster, Ellison, Ray, Ray, Binks: "Human macrophage migration inhibitory factor: a proven immunomodulatory cytokine?" in: The Journal of biological chemistry, Vol. 281, Issue 40, pp. 29641-51, 2006 (PubMed).