Dexamethasone (10 mM)

Details for Product No. ABIN412363, Supplier: Log in to see
Application
Functional Studies (Func), Enzyme Activity Assay (EAA), Inhibition Assay (InhA)
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Characteristics PubChem CID: 5743
Purity > 99 % by TLC
Chemical Name 9α-Fluoro-16α-methylprednisolone, Prednisolone F, (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione
Formula C₂₂H₂₉FO₅
Permeability Cell-permeable
Solubility Solubility: Soluble in ethanol (25 mg/mL)
Molecular Weight 392.46 g/mol
CAS-No 50-02-2
Comment

An anti-inflammatory glucocorticoid. Inhibits the expression of the inducible but not the constitutive nitric oxide synthase in vascular endothelial cells (IC50 = 5 nM). Enhances active cation transport in aortic smooth muscle cells by stimulating the Na+-K+ pump. Has anti-inflammatory and anti-rheumatic properties. Induces apoptosis in human thymocytes. In general, 500-1000 nM of dexamethasone is sufficient to induce apoptosis following a 6-hour incubation at 37 °C

Restrictions For Research Use only
Format Liquid
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 6 months
Supplier Images
 image for Dexamethasone (10 mM) (ABIN412363) Dexamethasone (10 mM)
Product cited in: Kudrin, Scott, Martin, Chung, Donn, McMaster, Ellison, Ray, Ray, Binks: "Human macrophage migration inhibitory factor: a proven immunomodulatory cytokine?" in: The Journal of biological chemistry, Vol. 281, Issue 40, pp. 29641-51, 2006 (PubMed).