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Q-VD-OPh (General Caspase Inhibitor)

Details for Product No. ABIN628968, Supplier: Log in to see
Blocking Reagent (BR), Inhibition Assay (InhA)
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Purpose A pan-caspase inhibitor
Sequence Quinolyl-Val-Asp-OPh
Characteristics A synthetic peptide that is potent, cell permeable, nontoxic and irreversibly inhibits caspase activity to blocks apoptosis. The new generation of caspase inhibitor is more stable in aqueous environment and exhibits several folds higher activity than the corresponding FMK caspase inhibitors. Q-VD-OPH is the inhibitor of choice for both in vitro and in vivo studies.
Q-VD-OPh is a potent pan-caspase inhibitor that protects cells from capsase-dependent apoptosis. Q-VD-OPh has superior aqueous stability, cell permeability, and efficacy than FMK-based caspase inhibitors and displays no cytotoxic effects alone.
Purity > 95 % by HPLC
Chemical Name (3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic acid hydrate
Formula C26H25F2N3O6 · xH2O
Permeability Cell-permeable
Solubility DMSO
Molecular Weight 513.49 Da
Application Notes We recommend using 1-10 µM concentration for in vitro enzyme kinetics studies. For in vivo usage, quantity needs to be determined by researcher. 20 mg/Kg of body weight is a proper place to start.
Restrictions For Research Use only
Format Lyophilized
Handling Advice Protect from light and moisture.
Storage -20 °C
Expiry Date 12 months
Supplier Images
 image for Q-VD-OPh (General Caspase Inhibitor) (ABIN628968) Q-VD-OPh (General Caspase Inhibitor)
Product cited in: Feng, Langereis, Lork, Nguyen, Hato, Lanke, Emdad, Bhoopathi, Fisher, Lloyd, van Kuppeveld: "Enterovirus 2Apro targets MDA5 and MAVS in infected cells." in: Journal of virology, Vol. 88, Issue 6, pp. 3369-78, 2014

Quick, Leser, Clarke, Tyler: "Activation of intrinsic immune responses and microglial phagocytosis in an ex vivo spinal cord slice culture model of West Nile virus infection." in: Journal of virology, Vol. 88, Issue 22, pp. 13005-14, 2014

Beck, Niessner, Smalley, Flaherty, Paraiso, Busch, Sinnberg, Vasseur, Iovanna, Drießen, Stork, Wesselborg, Schaller, Biedermann, Bauer, Lasithiotakis, Weide, Eberle, Schittek, Schadendorf, Garbe et al.: "Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells. ..." in: Science signaling, Vol. 6, Issue 260, pp. ra7, 2013

Frisan, Vandekerckhove, de Thonel, Pierre-Eugène, Sternberg, Arlet, Floquet, Gyan, Kosmider, Dreyfus, Gabet, Courtois, Vyas, Ribeil, Zermati, Lacombe, Mayeux, Solary, Garrido, Hermine, Fontenay: "Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes." in: Blood, Vol. 119, Issue 6, pp. 1532-42, 2012

Höglund, Nilsson, Muralidharan, Hasvold, Merta, Rudelius, Nikolova, Keller, Nilsson: "Therapeutic implications for the induced levels of Chk1 in Myc-expressing cancer cells." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 22, pp. 7067-79, 2011

Novgorodov, Chudakova, Wheeler, Bielawski, Kindy, Obeid, Gudz: "Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosis." in: The Journal of biological chemistry, Vol. 286, Issue 6, pp. 4644-58, 2011

Rana, Gupta, Gomez, Matsuyama, Chakrabarti, Agarwal, Agarwal, Agarwal, Wald: "Securinine induces p73-dependent apoptosis preferentially in p53-deficient colon cancer cells." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 6, pp. 2126-34, 2010

Yamanouchi, Morgan, Kato, Lengfeld, Zhang, Liu: "Effects of caspase inhibitor on angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 30, Issue 4, pp. 702-7, 2010

Höglund, Nilsson, Forshell, Maclean, Nilsson: "Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine." in: Blood, Vol. 113, Issue 18, pp. 4281-8, 2009