IKK-ε Kinase Inhibitor II

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Application
Blocking Reagent (BR), Inhibition Assay (InhA)
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Purpose An IKK-ε kinase inhibitor
Characteristics A benzimidazole analog that acts as a potent and selective inhibitor of IKK-epsilon kinase (IC50 = 40 nM), displays >125-fold selectivity over IKK-alpha and IKK-beta.
Purity ≥ 97 % by HPLC
Chemical Name 5-​(5,​6-​dimethoxy-​1H-​benzimidazol-​1-​yl)-​3-​[[2-​(methylsulfonyl)phenyl]methoxy]-​2-​thiophenecarbonitrile
Formula C₂₂H₁₉N₃O₅S₂
Permeability Cell-permeable
Solubility DMSO
Molecular Weight 469.53 g/mol
CAS-No 862812-98-4
Research Area Kinases/Phosphatases
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
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Product cited in: Palchetti, Starace, De Cesaris, Filippini, Ziparo, Riccioli: "Transfected poly(I:C) activates different dsRNA receptors, leading to apoptosis or immunoadjuvant response in androgen-independent prostate cancer cells." in: The Journal of biological chemistry, Vol. 290, Issue 9, pp. 5470-83, 2015 (PubMed).