MMP-9 Inhibitor

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Application
Blocking Reagent (BR), Inhibition Assay (InhA)
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Purpose A potent MMP-9 inhibitor
Characteristics A potent, selective, and reversible MMP-9 Inhibitor (IC50 = 5 nM). Inhibits MMP-1 (IC50 = 1.05 µM) and MMP-13 (IC50 = 113 nM) only at much higher concentrations.
Purity ≥ 95 % by HPLC
Chemical Name 2-(N-benzyl-4-methoxyphenylsulfonamido)-5-((diethylamino)methyl)-N-hydroxy-3-methylbenzamide
Formula C₂₇H₃₃N₃O₅S
Permeability Cell-permeable
Solubility DMSO
Molecular Weight 511.63 g/mol
CAS-No 1177749-58-4
Restrictions For Research Use only
Format Solid
Handling Advice Protect from light and air
Storage -20 °C
Expiry Date 60 months
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 image for MMP-9 Inhibitor (ABIN809592) MMP-9 Inhibitor
Product cited in: Aflaki, Stubblefield, Maniwang, Lopez, Moaven, Goldin, Marugan, Patnaik, Dutra, Southall, Zheng, Tayebi, Sidransky: "Macrophage models of Gaucher disease for evaluating disease pathogenesis and candidate drugs." in: Science translational medicine, Vol. 6, Issue 240, pp. 240ra73, 2014 (PubMed).