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BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity.
3'(2'),5'-bisphosphate nucleotidase 1
, 3'(2'), 5'-bisphosphate nucleotidase 1
, 3'(2'),5'-bisphosphate nucleotidase 1-like
, PAP-inositol 1,4-phosphatase
, bisphosphate 3'-nucleotidase 1
, scHAL2 analogous 3