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Both dorsal raphe serotonergic activity during aversive reinforcement and amygdala serotonin 2C receptor (5-HT2CR) activity during memory consolidation were necessary for stress enhancement of fear memory, but neither process affected fear memory in unstressed mice. Prior stress increased amygdala sensitivity to serotonin by promoting 5-HT2CR surface expression without affecting tissue levels of serotonin in the amygdala.
heterodimerization with 5-HT2C receptors does not alter 5-HT2C Galphaq (show GNAQ Proteins)-dependent inositol phosphate signaling, 5-HT2A or 5-HT2B receptor (show HTR2B Proteins)-mediated signaling was totally blunted. This feature can be explained by a dominance of 5-HT2C on 5-HT2A and 5-HT2B receptor (show HTR2B Proteins) binding; in 5-HT2C-containing heterodimers, ligands bind and activate the 5-HT2C protomer exclusively.
results demonstrate that CHL1 regulates signal transduction pathways through constitutively active 5-HT2c receptor isoforms, thereby altering 5-HT2c receptor functions and implicating CHL1 as a new modulator of the serotonergic system.
Social Behavioral Deficits Coincide with the Onset of Seizure Susceptibility in Mice Lacking Serotonin Receptor 2c.
This study showed that reduced expression of the 5ht1c which modulate antidepressant action in hippocampus.
Suppressed feeding behavior in novelty stress-exposed aged male mice may be mediated by 5-HT(2C)R hypersensitivity, leading to hypoghrelinemia. The hypersensitivity may partly be due to estrogen receptor (show ESR1 Proteins) activation in aged male mice.
Results show that mice solely expressing the unedited INI (show PHF5A Proteins) form of 5-HT2C receptors exhibit a hyperactive HPA (show HPSE Proteins) axis driven by increased CRH (show CRH Proteins), a normal response to chronic stress and decreased depressive-like behaviors and fear-associated memory
Chronic intermittent ethanol upregulates 5HT2C receptor signaling in the bed nucleus of the stria terminalis.
findings show that enhanced alcohol drinking behaviour in mice is associated with the degree of 5-HT(2C)R mRNA editing in the nucleus accumbens and dorsal raphe nuceus
Precise temporal control of Gq signals in 5-HT2c-R domains in GABAergic neurons upstream of 5-HT (show DDC Proteins) neurons provides negative feedback regulation of serotonergic firing to modulate anxiety-like behavior in mice.
We examined cortisol reactivity to a social evaluative stressor in the laboratory. The HTR2C Cys23 allele was associated with greater cortisol reactivity. The consistency of the results across the two sites in this paper as well as the additional site in the companion paper (total N = 426) provides strong support for an association of the Cys23Ser polymorphism with cortisol reactivity in the Trier Social Stress Test.
Authors found that 22 patients presented the -759C/T polymorphism in 5-HTR2C gene.
This study demonstrated that -759C>T Polymorphism of the HTR2C Gene is Associated with Second Generation Antipsychotic-Induced Weight Gain in Female Patients with Schizophrenia.
the occurrence of hyperprolactinemia, although asymptomatic, was higher in the presence of the C allele of the rs6318 SNP of the HTR2C gene.
SLC6A14 (show Slc6a14 Proteins) and 5-HTR2C polymorphisms are associated with food intake and nutritional status in children.
RNA element is discovered, which coordinates site-specific RNA editing on HTR2C pre-mRNA by an in vitro editing assay and secondary structural analysis of mutant HTR2C RNA fragments.
No significant differences were found between the genotype distribution and allele frequencies of the OSAHS group and the control group regarding the T102C polymorphisms of the 5-HTR (show F2R Proteins) 2A gene and the G796C polymorphisms of the 5-HTR (show F2R Proteins) 2C gene.
Results of the present study do not support a major role of SNPs of HTR2C rs1414334 in the regulation of weight gain or association of serum levels in patients with schizophrenia on clozapine treatment.
ADARB1 (show ADARB1 Proteins) rs9983925 and rs4819035 and HTR2C rs6318 were associated with suicide attempt risk.
although the expression of the long transcriptional variant of HTR2C is raised in infanticidal animals, the overall patterns of editing in the hypothalamus are similar between the two states.
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. Three transcript variants encoding two different isoforms have been found for this gene.
serotonin receptor 2C
, 5-HT2C receptor
, 5-hydroxytryptamine receptor 1C
, 5-hydroxytryptamine receptor 2C
, 5-hydroxytryptamine receptor-1c
, serotonin 5-HT-2C receptor
, serotonin 1c receptor
, 5-alpha-hydroxytryptamine receptor 2C