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Data suggest MTMR3 has multiple functions in regulation of autophagy; one mechanism appears to be direct interaction between MTMR3 and mTORC1 (MTOR (show FRAP1 ELISA Kits), mLST8 (show MLST8 ELISA Kits), raptor (show RPTOR ELISA Kits)) which inhibits phosphorylation activity of mTORC1; MTMR3 is localized to Golgi apparatus.
the rs713875 IBD risk polymorphism increases MTMR3 expression, which modulates pattern recognition receptor (PRR (show PVRL1 ELISA Kits))-induced outcomes, including increased induced caspase-1 (show CASP1 ELISA Kits) activation
myotubularin-related protein 3 and myotubularin-related protein 4 may act as a bridge between CEP55 (show CEP55 ELISA Kits) and polo-like kinase 1 (show PLK1 ELISA Kits), ensuring proper CEP55 (show CEP55 ELISA Kits) phosphorylation and regulating CEP55 (show CEP55 ELISA Kits) recruitment to the midbody.
cloning, expression, purification and crystallization of human myotubularin-related protein 3 encompassing the PH-GRAM and the phosphatase catalytic domain are reported
These results indicate that MTMR3 may play an important role in the progression of CRC (show CALR ELISA Kits) and suggest that siRNA mediated silencing of MTMR3 could be an effective tool in CRC (show CALR ELISA Kits) treatment.
Our results suggest that the MTMR3 gene is shared between IgA nephropathy and lupus nephritis in the northern Chinese population, further highlighting the role of autophagy in systemic lupus erythematosus.
Data suggest MTMR3, PIKFYVE (phosphoinositide kinase FYVE), and their product phosphatidylinositol 5-phosphate are involved in activation of RAC1 (rho family small GTP binding protein); this process regulates migration/invasion of carcinoma/sarcoma.
Production of phosphatidylinositol 5-phosphate via PIKfyve (show PIKFYVE ELISA Kits) and MTMR3 regulates cell migration.
MTMR3 belongs to the myotubularin (show MTM1 ELISA Kits) family of phosphoinositides phosphatases
MTMR3 shares similar phosphatase activity and substrate specificity with its homologous proteins MTM1 (show MTM1 ELISA Kits) and MTMR3
This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene.
myotubularin-related protein 3
, myotubularin related protein 3
, myotubularin-related protein 3-like
, FYVE (Fab1 YGLO23 Vsp27 EEA1 domain) dual-specificity protein phosphatase
, FYVE domain-containing dual specificity protein phosphatase 1
, zinc finger FYVE domain-containing protein 10
, zinc finger, FYVE domain containing 10