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Impairment of PGAP3 causes a subtype of hyperphosphatasia with intellectual disabilities, a congenital disorder of glycosylation that is also referred to as Mabry syndrome.
Data show that glycosylphosphatidylinositol-anchored proteins (GPI (show GNPDA1 Antibodies)-APs (show SH2B2 Antibodies)) are secreted into the medium by cells overexpressing PGAP3.
These findings revealed the association of PERLD1 as a novel asthma candidate gene and reinforced the involvement of genes on the 17q12-21 chromosomal region in the etiology of asthma.
MGC9753, consisting of eight exons, clustered with PPP1R1B (show PPP1R1B Antibodies), STARD3 (show STARD3 Antibodies), TCAP (show TCAP Antibodies), PNMT (show PNMT Antibodies), ERBB2 (show ERBB2 Antibodies), MGC14832 and GRB7 (show GRB7 Antibodies) genes within the 120-kb region of chromosome 17q12; PPP1R1B (show PPP1R1B Antibodies), STARD3 (show STARD3 Antibodies), MGC9753, ERBB2 (show ERBB2 Antibodies) and GRB7 (show GRB7 Antibodies) genes are co-amplified in several cases of gastric cancer
Oncogenomic recombination hotspot around the PPP1R1B (show PPP1R1B Antibodies)-STARD3 (show STARD3 Antibodies)-TCAP (show TCAP Antibodies)-PNMT (show PNMT Antibodies)-PERLD1-ERBB2 (show ERBB2 Antibodies)-C17orf37 (show C17orf37 Antibodies)-GRB7 (show GRB7 Antibodies) amplicon at human chromosome 17q12 is closely linked to evolutionary recombination hotspot around the GSDML (show GSDMB Antibodies)-GSDM (show GSDMA Antibodies) locus.
the response of T cells was enhanced in Pgap3 knockout mice in both in vitro and in vivo studies, including alloreactive response, antigen-specific immune response, and experimental autoimmune encephalomyelitis.
Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (By similarity).
post-GPI attachment to proteins factor 3
, post-GPI attachment to proteins 3
, COS16 homolog
, PER1-like domain-containing protein 1
, gene coamplified with ERBB2 protein
, per1-like domain containing 1
, post-GPI-attachment to proteins 3