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anti-Rat (Rattus) PIK3C2B Antibodies:
anti-Human PIK3C2B Antibodies:
anti-Guinea Pig PIK3C2B Antibodies:
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Class II enzyme PI3K-C2beta and the class IB isozyme p110gamma (show PIK3CG Antibodies) mainly regulate the S1P (show MBTPS1 Antibodies)- and high density lipoprotein (HDL (show HSD11B1 Antibodies))-dependent endothelial cell (EC) migration and PI3K-C2alpha (show PIK3C2A Antibodies) primarily controls EC survival
Data suggest a novel role for nucleotide-free Ras in cell signaling in which PI3KC2beta stabilizes nucleotide-free Ras and that interaction of Ras and PI3KC2beta mutually inhibit one another.
The results of this study showed that strong association between PIK3C2B gene alternation and high-grade oligodendroglial tumors.
These findings provide a unique mechanism for regulating class II PI3Ks, and identify TRIM27 (show RFP Antibodies) as a previously undescribed negative regulator of CD4 (show CD4 Antibodies) T cells.
Overexpression of PIK3C2B is associated with esophageal squamous cell carcinoma.
different human small cell lung carcinoma cell lines overexpress distinct subsets of PI3Ks, resulting in differences in signalling cascades activated by stem cell factor (show KITLG Antibodies); insights into specificity and functional significance of PI3K (show PIK3CA Antibodies) signalling in cancer
activity of nuclear phosphoinositide 3-kinase C2beta investigated in HL-60 cells induced to differentiate along granulocytic or monocytic lineages
identified the 185-kDa protein altered by nitrotyrosylation in platelets from patients with systemic sclerosis as phosphoinositide kinase C2beta (PI 3 (show PI3 Antibodies)-K); the activity of PI 3 (show PI3 Antibodies)-K increases in nitrotyrosylated platelet lystaes from patients with SSc (show CYP11A1 Antibodies)
Class II phosphoinositide 3-kinase C2beta isnot essential for epidermal differentiation
Epidermal growth factor (show EGF Antibodies) stimulates the appearance of PI3K-C2beta in nuclei.
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.
nuclear cap binding protein subunit 2
, phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta
, phosphoinositide-3-kinase, class 2, beta polypeptide
, PTDINS-3-kinase C2 beta
, phosphatidylinositol 3-kinase C2 domain-containing beta polypeptide
, phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
, phosphoinositide 3-kinase-C2-beta
, ptdIns-3-kinase C2 subunit beta