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anti-Mouse (Murine) Antibodies:
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PI3K-C2gamma-KO mice display reduced liver glycogen (show GYS1 Antibodies) accumulation and develop hyperlipidemia, adiposity and insulin (show INS Antibodies) resistance with age or high-fat diet.
Data reveals that class II phosphoinositide 3-kinase gamma (PI3KC2gamma) expression is markedly down-regulated by p185 (show CUL7 Antibodies)(Bcr-Abl (show ABL1 Antibodies)) but not p185 (show CUL7 Antibodies)(Delta176-426).
Lipopolysaccharide can induce high mobility group box 1 (HMGB1 (show HMGB1 Antibodies)) secretion by viable cardiac myocytes through a toll-like receptor 4 (show TLR4 Antibodies)/phosphatidylinositol 3-kinase gamma signaling pathway.
Data indicate substituents of benzensulfonamide and pyrazine as phosphoinositide 3-kinase-C2gamma (PI3K-C2GAMMA) inhibitors.
The associations of five SNPs (SNPs1-5: A-5468G, A-3333G, C-1794T, C437T and T9148C) of the class II phosphoinositide 3-kinase gamma-subunit (PIK3C2G) gene with type 2 diabetes were examined.
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The biological function of this gene has not yet been determined.
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
, ptdIns-3-kinase C2 subunit gamma
, PTDINS-3-kinase C2 gamma
, phosphatidylinositol 3-kinase C2 domain-containing gamma
, phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide
, phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma
, phosphoinositide 3-kinase-C2-gamma
, phosphoinositide-3-kinase, class 2, gamma polypeptide
, phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
, phosphoinositide 3-Kinase-C2-gamma
, ptdIns-3-kinase C2 gamma