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the rs7088318 (PIP4K2A) and rs2239633 (CEBPE (show CEBPE ELISA Kits)) polymorphisms were not associated with ALL risk.
PIP5K2A is possibly involved in a mechanism protecting against tardive dyskinesia-inducing neurotoxicity.
The diplotype ATTGCT/ATTGCT of the PIP4K2A gene confers approximately three-times higher incomplete responsiveness towards antipsychotics in severely ill patients.
PIP4K2A to be essential for the clonogenic and leukemia-initiating potential of human AML (show RUNX1 ELISA Kits) cells, and for the clonogenic potential of murine MLL (show MLL ELISA Kits)-AF9 (show MLLT3 ELISA Kits) AML (show RUNX1 ELISA Kits) cells.
We also showed that PIPKIIalpha silencing can induce alpha and gamma globin expression and decrease cell proliferation in K562 cells.
Overexpression of type 2A PI(4)P5-kinase (PIP5K (show PIKFYVE ELISA Kits) 2A) significantly reduced tamoxifen inhibition of Kv7.2 (show KCNQ2 ELISA Kits)/Kv7.3 (show KCNQ3 ELISA Kits) and Kv7.2 (show KCNQ2 ELISA Kits) R463Q channels.
The data suggest that PI5P4Ka N251S does not significantly differ in activity from the wild-type enzyme, throwing a new light on its association with schizophrenia.
Knocking down PI5P4Kalpha and beta in a breast cancer cell line bearing an amplification of the gene encoding PI5P4K beta and deficient for p53 (show TP53 ELISA Kits) impaired growth on plastic and in xenografts.
Variation at 10p12.2 (PIP4K2A) and 10p14 (GATA3 (show GATA3 ELISA Kits)) influences risk of acute lymphoblastic anemia and tumor subtype. (Meta-analysis)
PIP5K2A variant influences susceptibility to schizophrenia in the Russian population of Siberia. Authors studied 355 patients with schizophrenic disorders from the Russian population of Siberia.
Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family.
phosphatidylinositol-4-phosphate 5-kinase, type II, alpha
, phosphatidylinositol-4-phosphate 5-kinase type II alpha
, 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha
, 1-phosphatidylinositol-4-phosphate kinase
, 1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha
, PI(5)P 4-kinase type II alpha
, PtdIns(4)P-5-kinase B isoform
, diphosphoinositide kinase 2-alpha
, phosphatidylinositol 5-phosphate 4-kinase type II alpha
, phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha
, ptdIns(4)P-5-kinase C isoform
, ptdIns(5)P-4-kinase isoform 2-alpha
, type II phosphatidylinositol-4-phosphate 5-kinase 53 K isoform
, 1-phosphatidylinositol-5-phosphate 4-kinase A
, PIPK2 alpha
, phosphatidylinositol-5-phosphate 4-kinase type II alpha