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Data show that glycation end products (AGE) increase PIP2 production, arachidonic acid release and reactive oxygen species via cytosolic phospholipase A2 activation, and inhibit Na+ K+ ATPase (show ATP1A1 Proteins) surface expression via PIP5Kgamma (show PIP5K1C Proteins).
this study shows that cPLA2alpha contributes to immune surveillance and host defense in the lung to prevent infection by the commensal fungus Candida albicans and to dampen inflammation
Reduction of cPLA2alpha in the brainstem and spinal cord significantly attenuated the development of an animal model of amyotrophic lateral sclerosis.
Data suggest that the ability of pyrrophenone to block endoplasmic reticulum (ER) calcium release is an off-target effect since it occurs in fibroblasts lacking cytosolic phospholipase A2alpha (cPLA2alpha).
these results show that preadipocyte cPLA2alpha activation is a hitherto unrecognized factor for adipogenesis in vitro and in vivo.
The data emphasize the importance of the PLCeta2 EF-hand domain and articulation of PLCeta2 with LIMK-1 (show LIMK1 Proteins) in regulating neuritogenesis.
show that accumulation of Abeta (show APP Proteins) induced elevation of APP (show APP Proteins) protein expression mediated by cPLA2 alpha, PGE2 release, and CREB (show CREB1 Proteins) activation via protein kinase A pathway
Prostaglandins from cPLA2-alpha/COX1 pathway and mitogen-activated protein kinases regulate gene expression in Candida albicans-infected macrophages.
Thymocyte maturation can occur independently of cPLA2-alpha.
The study reports the formation of a multiprotein complex at the G2-to-M transition in vitro and in vivo. Group IVA cytosolic phospholipase A2 (cPLA2-alpha) acts as a bridge in this complex to promote binding of SIRT2 (show SIRT2 Proteins) to cyclin A (show CCNA2 Proteins)-Cdk2 (show CDK2 Proteins).
osteoblastic cytosolic phospholipase A2 is crucially involved in ET-1 (show EDN1 Proteins)-induced prostaglandin formation.
cPLA2alpha activates PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) and inhibits Smad2 (show SMAD2 Proteins)/3 during epithelial-mesenchymal transition of hepatocellular carcinoma cells.
Phospholipase activity is linked to energy metabolism, revealing cPLA2 as a central regulator of both lipidomics and energy flux.
present study indicates that among all cytosolic phospholipases A2, specific phospholipase A2 group IVA are the main enzymes involved in cigarette smoke induced anomalies in type I and type II lung epithelial cells
genetic association study in Quebec City population: Data suggest total plasma n-6 fatty acid phospholipid levels and C-reactive protein (show CRP Proteins) are modulated by SNPs in PLA2G4A and PLA2G6 (show PLA2G6 Proteins) alone or in combination with fish oil dietary supplementation.
cPLA2alpha plays an important role in cell cycle re-entry by quiescent prostate cancer cells
These studies constitute a definitive account, demonstrating the fundamental role of cPLA2alpha to eicosanoid formation and cellular responses within the human circulation.
EGF (show EGF Proteins) stimulates platelet-activating factor production in ovarian cancer cells in a manner that requires cPLA2.
We conclude that cPLA2alpha is required for sustaining AKT (show AKT1 Proteins) phosphorylation at Ser473 and cell proliferation in colorectal cancer cells with PI3K (show PIK3CA Proteins) mutation
result suggests that cPLAPgamma may act as a G protein, activating cPLA(2)alpha prior to reaching full intracellular Ca(2 (show CA2 Proteins) ) concentrations
Ovulation is associated with an LH/hCG (show CGA Proteins)-dependent induction of PLA2G4A in GC via the adenylyl cyclase/cAMP pathway.
Activation of cytosolic phospholipase A2 and fatty acid transacylase is essential but not sufficient for thrombin (show F2 Proteins)-induced smooth muscle cell proliferation.
The results indicate that PLA2 (show YWHAZ Proteins) activity in equine endometrium changes with the stage of the oestrous cycle and thus may be influenced by systemic hormone concentrations.
During pregnancy, PLA2 (show YWHAZ Proteins) expression may be sufficient to initiate the cascade for prostaglandin f2alpha secretion and does not play a direct role in maternal recognition of pregnancy.
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
cytosolic phospholipase A2
, phospholipase A2 group IVA
, Phospholipase A2 group IVA
, Cytosolic phospholipase A2 (CPLA2)
, Type IV PLA2
, cytosolic PLA2
, phospholipase A2, group 4
, calcium-dependent phospholipid-binding protein
, phosphatidylcholine 2-acylhydrolase
, phospholipase A2 cytosolic
, phospholipase A2, group IB (pancreas)