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Human PTPMT1 Protein expressed in Escherichia coli (E. coli) - ABIN667999
Merlot, Meili, Pagliarini, Maehama, Dixon, Firtel: A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi. in The Journal of biological chemistry 2003
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A key role for HIF-2alpha (show EPAS1 Proteins)-induced Ptpmt1 up-regulation in proliferation, survival and glucose metabolism of erythroleukemia cells.
our data support a model in which MK-STYX (show STYXL1 Proteins) controls apoptosis by negatively regulating PTPMT1.
Our data suggest that inhibition of PTPMT1 causes a metabolic crisis in cancer cells that induces cell death, and may be a mechanism by which cancer cells can be sensitized to currently available therapies.
Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation.
Targeted disruption of Ptpmt1 in mice results in postimplantation lethality.
mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis
PTPMT1 is targeted to the mitochondrion by an N-terminal signal sequence and is found anchored to the matrix face of the inner membrane. Knockdown of PTPMT1 in INS-1 832/13 cells enhances ATP production and insulin (show INS Proteins) secretion.
mouse homolog is a phosphatase which specifically catalyzes the conversion of phosphatidylinositol 5-phosphate to phosphatidylinositol
protein tyrosine phosphatase, mitochondrial 1
, protein-tyrosine phosphatase mitochondrial 1
, NB4 apoptosis/differentiation related protein
, PTEN-like phosphatase
, phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
, phosphoinositide lipid phosphatase