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anti-Mouse (Murine) TPTE2 Antibodies:
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A novel mouse xenograft model to study the role of TSLP (show TSLP Antibodies)-induced CRLF2 (show CRLF3 Antibodies) signals in normal and malignant human B lymphopoiesis has been developed.
High-cholesterol diet increased TSLPR (show CRLF2 Antibodies) expression and atherosclerosis. High-dose ticagrelor moderated this trend. It modulated platelet activity and atherosclerosis mediated by TSLPR (show CRLF2 Antibodies), potentially through the PI3K/Akt (show AKT1 Antibodies) signal pathway.
Activating thymic stromal lymphopoietin (show TSLP Antibodies) promotes atherosclerosis by inducing Th17/Treg imbalance through TSLPR (show CRLF2 Antibodies) signaling in a mouse model.
Suggest that Treg defects in ApoE (show APOE Antibodies)(-/-) mice might partially be attributed to the disruption of TSLP (show TSLP Antibodies)-TSLPR (show CRLF2 Antibodies)-LAP signaling in epithelial cells and dendritic cells.
The structure of the mouse TSLP (show TSLP Antibodies)-mediated signaling complex reveals how TSLP (show TSLP Antibodies) establishes extensive interfaces with its cognate receptor (TSLPR (show CRLF2 Antibodies)).
TSLPR (show CRLF2 Antibodies) helps to create a permissive microenvironment for the development and pulmonary metastasis of mammary carcinoma in a mouse model using implanted 4T1 tumour cells.
A previously unrecognized role was found for TSLP (show TSLP Antibodies)/TSLPR (show CRLF2 Antibodies) signaling in type 2 immunity as an important enhancer for the development of alternately activated macrophages as well as for chemokine (show CCL1 Antibodies) production.
mice deficient in TSLP receptors on LCs abrogated the induction of OVA-specific IgE levels upon epicutaneous OVA sensitization.
Increased susceptibility to autoimmune gastritis in thymic stromal lymphopoietin receptor (show CRLF2 Antibodies)-deficient mice.
Presence of functional TSLP (show TSLP Antibodies)-specific receptor chain is required for the development of T helper cell type (Th)2 contact hypersensitivity to the hapten fluorescein isothiocyanate (FITC).
The role of TPTE2 in gallbladder cancer cells
TPTE2 was originally reported to be a phosphoinositide 3'-phosphatase, like the tumor suppressor PTEN (show PTEN Antibodies). Later on, other homologous phosphatases, such as Ci-VSP (show TPTE Antibodies) and Dr-VSP (show TPTE Antibodies), have been described. These proteins are 5'-phosphatases. More recently, using a chimeric construct, we have shown that the catalytic domain of TPTE2 behaves as a 5'-phosphatase as well.
findings suggest that C2-domain of TPIP-C2 may act as a dominant negative effector, which may bind to and arrest the cell proliferation signalling complex
the TPIP splice-variant (TPIP-C2) mRNA is expressed in human and mouse tissues and strongly inhibits cell growth in HeLa cells
TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.
, TSLP receptor
, cytokine receptor-like molecule 2
, delta 1
, lymphocyte antigen 114
, thymic stromal lymphopoietin protein receptor
, thymic stromal-derived lymphopoietin, receptor
, transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
, type I cytokine receptor delta 1
, PTEN-like inositol lipid phosphatase
, TPIP lipid phosphatase
, TPTE and PTEN homologous inositol lipid phosphatase
, lipid phosphatase TPIP
, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2
, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2