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Osteoprotegerin (show TNFRSF11B Proteins) facilitates pulmonary arterial hypertension pathogenesis by regulating pulmonary arterial smooth muscle cell proliferation via integrin alphavbeta3 (show ITGAV Proteins)/FAK (show PTK2 Proteins)/AKT (show AKT1 Proteins) signaling pathway.
Suggest that alphavbeta3 integrin plays an important role in coordinating hepatocyte division during liver regeneration after partial hepatectomy via crosstalk with fibrin ECM (show MMRN1 Proteins).
Knock-in mice expressing a CCN1 mutant that is unable to bind alphavbeta5/alphavbeta3 were impaired in ductular reaction. CCN1, acting through its alphav beta3/alphav beta5 binding site, is critical for survival after bile duct ligation.
Myo7a interacts with integrin beta5 and selectively promotes integrin alphavbeta5-mediated cell migration
Integrin-beta5 and zyxin (show ZYX Proteins) mediate formation of ventral stress fibers in response to transforming growth factor beta.
Phosphatidylserine-marked tips do not vary in mice lacking the diurnal phagocytic rhythm of the retinal epithelium due to loss of either alphavbeta5 integrin, or its extracellular ligand milk fat globule-EGF factor 8 (show MFGE8 Proteins).
Data suggest that the alphavbeta3 and alphavbeta5 integrins are not essential for mediating microglial activation responses to vitronectin (show VTN Proteins), but that microglia use multiple redundant receptors to mediate interactions with this ECM (show MMRN1 Proteins) protein.
Angiopoietin-like 4 (show ANGPTL4 Proteins) interacts with integrins beta1 and beta5 to modulate keratinocyte migration.
There is a critical role for the alphavbeta5/beta6 integrins in mediating the IL-1beta (show IL1B Proteins)-induced acute lung injury.
Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway
Findings indicate integrin inhibition as a promising strategy to block both aryl hydrocarbon receptor (AhR (show AHR Proteins)) and transforming growth factor beta (TGF-beta)-controlled features of malignancy in glioblastoma.
High ITGB5 expression is associated with cervical cancer.
Data suggest that the binding, but not the internalization of photoreceptor outer segments (POS) confers protective effects on retinal pigment epithelium (RPE) cells through the alphavbeta5 integrin/focal adhesion kinase (FAK)/PGC-1alpha pathway.
ITGA3, ITGA6, ITGB3,ITGB4 and ITGB5 are associated with GC susceptibility (rs2675), ITGA3, ITGA6, ITGB3, ITGB4 and ITGB5 are associated with gastric cancer susceptibility tumor stage and lymphatic metastasis in Chinese Han population
FAK (show PTK2 Proteins) activity regulates beta5 integrin expression and anchorage-independent cell growth in ovarian carcinoma.
Integrins alphavbeta5 and alphavbeta3 both control myofibroblast differentiation by activating latent TGF-beta1 (show TGFB1 Proteins)
FRMD5 regulates tumor cell motility via a dual pathway involving FRMD5 binding to integrin beta5 tail and to ROCK1 (show ROCK1 Proteins)
Immunohistochemical analysis for alphavbeta3, alphavbeta5 and alphavbeta6 integrin subunits was performed and correlated with Ki67 (show MKI67 Proteins) and hypoxia-inducible factor (HIF)-1alpha (show HIF1A Proteins) indexes
we demonstrated via antibody blocking experiments that aV b5 and a6 significantly promoted hESC attachment in 2%oxygen only, whereas blockage of CD44 (show CD44 Proteins) inhibited cell attachment in 21% O2 alone
These results demonstrate the critical role of the RhoA (show RHOA Proteins)/alphavbeta5 integrin pathway in mediating Pseudomonas aeruginosa-induced lung vascular permeability.
beta chain of integrin\; mouse homolog only forms a heterodimer with alphaV and acts as a vitronectin receptor
integrin, beta 5
, integrin beta 5
, integrin beta-5