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Osteoprotegerin (show TNFRSF11B ELISA Kits) facilitates pulmonary arterial hypertension pathogenesis by regulating pulmonary arterial smooth muscle cell proliferation via integrin alphavbeta3 (show ITGAV ELISA Kits)/FAK (show PTK2 ELISA Kits)/AKT (show AKT1 ELISA Kits) signaling pathway.
FAK sustained the active integrin conformation by maintaining talin association with Rab11 endosomes in a type I phosphatidylinositol phosphate kinase (PIPKIgamma)-dependent manner.
cells on fibronectin (show FN1 ELISA Kits) suppressed cAMP via enhanced phosphodiesterase (PDE (show TWIST1 ELISA Kits)) activity, through direct binding of integrin alpha5 to phosphodiesterase-4D5
this study shows that protective effect of osteopontin (show SPP1 ELISA Kits) results from integrin-alpha5-dependent enhancement of neutrophil migration and accumulation at sites of infection
Gdf-5 (show GDF5 ELISA Kits) induced the expression of the alpha5 sub-unit, while Bmp-7 (show BMP7 ELISA Kits) induced the expression of the alphaV sub-unit.
EGFR (show EGFR ELISA Kits) activation can be regulated by the N-glycosylation of integrin alpha5, which is a novel molecular paradigm for the cross-talk between integrins and growth factor receptors
An (as yet unknown) integrin alpha5-dependent signal extrinsic to the pharyngeal endothelium mediates the formation of the 4th pharyngeal arch arteries through fibronectin (show FN1 ELISA Kits).
Suggest that alpha5beta1-mediated cross-talk between fibronectin (show FN1 ELISA Kits) and oxLDL regulates inflammation in early atherogenesis and that therapeutics that inhibit alpha5 integrins may reduce inflammation without adversely affecting plaque structure.
our data point to a potential role for the fibronectin (show FN1 ELISA Kits)-alpha5beta1 integrin interaction in promoting vascular remodeling during demyelinating disease
high expression of the ppGalNAc-T13 (show GALNT13 ELISA Kits) gene generates tTn (show TTN ELISA Kits) antigen on Syndecan 1 (show SDC1 ELISA Kits), leading to enhanced invasion and metastasis via the formation of a complex consisting of integrin alpha5beta1, Syndecan 1 (show SDC1 ELISA Kits), and MMP-9 (show MMP9 ELISA Kits) in the glycolipid-enriched microdomain/rafts.
alpha5beta1 integrin can stimulate drug resistance in cancer cells via a mechanism based on inhibition of protein kinase (show CDK7 ELISA Kits) Erk (show EPHB2 ELISA Kits).
We measured the effect of recombinant Gal-3 (show LGALS3 ELISA Kits) added exogenously on the lateral mobility of the alpha5b1 integrin on HeLa cells. Using single-particle tracking (SPT (show AGXT ELISA Kits)) we detected increased lateral mobility of the integrin in the presence of Gal-3 (show LGALS3 ELISA Kits), while its truncated C-terminal domain (Gal (show GAL ELISA Kits)-3C) showed only minor reductions in lateral mobility.
Eps8 (show EPS8 ELISA Kits)/Abi1 (show ABI1 ELISA Kits)/Sos1 (show SOS1 ELISA Kits) tricomplex acts as a key molecular switch altering the balance between Rac1 and Rho activation; its presence or absence in pancreatic ductal adenocarcinoma cells modulates alphavbeta6-dependent functions, resulting in a pro-migratory (Rac1-dependent) or a pro-TGF-beta1 (show TGFB1 ELISA Kits) activation (Rho-dependent) functional phenotype.
Findings indicate integrin inhibition as a promising strategy to block both aryl hydrocarbon receptor (AhR (show AHR ELISA Kits)) and transforming growth factor beta (TGF-beta)-controlled features of malignancy in glioblastoma.
Suggest an adhesion-dependent mechanism of RUNX2 (show RUNX2 ELISA Kits) for the osteotropism and bone colonization of breast cancer cells and implicate RUNX2 (show RUNX2 ELISA Kits) and integrin alpha5 as potential molecular markers for the prediction of bone metastasis.
cells on fibronectin (show FN1 ELISA Kits) suppressed cAMP via enhanced phosphodiesterase (PDE (show ALDH7A1 ELISA Kits)) activity, through direct binding of integrin alpha5 to phosphodiesterase-4D5
Data show that high mobility group nucleosomal binding domain 2 (HMGN2 (show HMGN2 ELISA Kits)) knockdown induced the increased expression of alpha5beta1 integrin on cell membranes, which resulted in a significant increase in Klebsiella pneumoniae internalization.
ITGA5 expression is significantly upregulated in human masticatory mucosa during wound healing
ectopic expression of miR-17 in ovarian cancer cells resulted in repressed ILK (show ILK ELISA Kits) phosphorylation as well as decreased production of active matrix metalloproteinase-2 (MMP-2 (show MMP2 ELISA Kits)). Our results indicated that miR-17 hampered ovarian cancer peritoneal propagation by targeting integrin a5 and b1.
Putative function of fibronectin (show FN1 ELISA Kits) and its receptor (integrin alpha(5)beta(1)) in male and female gametes during bovine fertilization in vitro.
Results indicate that XIAP (show XIAP ELISA Kits) stabilizes the alpha(5)-integrin-associated focal adhesion complex, thereby further regulating endothelial cell adhesion and migration.
alphavbeta3 integrin engagement in vascular endothelium regulates Ca2 (show CA2 ELISA Kits)+-dependent K+ current
Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
, CD49 antigen-like family member E
, fibronectin receptor alpha polypeptide
, fibronectin receptor subunit alpha
, integrin alpha-5
, integrin alpha-F
, fibronectin receptor, alpha subunit
, very late activation protein 5, alpha subunit
, integrin alpha 5 (fibronectin receptor alpha)