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anti-Human GRF2 Antibodies:
anti-Mouse (Murine) GRF2 Antibodies:
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Human Monoclonal GRF2 Primary Antibody for IA, IP - ABIN2192053
Lachmann, Oldroyd, Milstein, Wright: Three rat monoclonal antibodies to human C3. in Immunology 1981
Show all 2 Pubmed References
Human Monoclonal GRF2 Primary Antibody for ELISA, WB - ABIN561125
Nolz, Nacusi, Segovis, Medeiros, Mitchell, Shimizu, Billadeau: The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1. in The Journal of cell biology 2008
C3G/RAP1 activity is involved in the metastatic spread of epithelial ovarian cancer.
C3G plays an important role in platelet clotting through a mechanism involving its GEF (show SLC2A4RG Antibodies) activity and suggest that it might be also involved in neutrophil development.
The possibility of cellular phospho-C3G (pC3G) being a substrate of the intracellular T-cell protein tyrosine phosphatase TC-PTP (show PTPN2 Antibodies) (PTPN2 (show PTPN2 Antibodies)) using the human neuroblastoma (show ARHGEF16 Antibodies) cell line, was studied.
Lyn (show LYN Antibodies) controls spatial activation of Rap1 (show RABGEF1 Antibodies) by recruiting the CrkL (show CRKL Antibodies)-C3G protein complex to the leading edge
found somatic demethylation of a relaxed-criterion CpG island (CGI-B) located in the first intron of RAPGEF1 in 40% of colon cancers and 8% of gastric cancers relative to their matching normal tissues that were always methylated
Data demonstrated that the polymorphism in TP53 (show TP53 Antibodies) (rs1042522) was associated with type 2 diabetes, and that potential interaction of TP53 (show TP53 Antibodies) (rs1042522) and RAPGEF1 (rs11243444), or NRF1 (show NFE2L1 Antibodies) (rs1882095) increased the risk of type 2 diabetes.
significant positive correlation between layers II and IV of the dorso-lateral prefrontal cortex in the percentage of MR-GEF expressing neurons in individuals with bipolar disorder
C3G overexpression induces neurite-like extensions in MDA-MB-231 and BT549 breast carcinoma cells and not in a variety of other cancer cell lines examined.
C3G as a novel target of c-Abl
ALK (show ALK Antibodies) activation of Rap1 (show RABGEF1 Antibodies) via the Rap1 (show RABGEF1 Antibodies)-specific GEF (show SLC2A4RG Antibodies) C3Gmay contribute to cell proliferation and oncogenesis of neuroblastoma (show ARHGEF16 Antibodies).
C3G is required in cortical neurons for both the specification of an axon and the initiation of radial migration by forming a leading process.
results provide evidence that C3G plays an important role in myogenic differentiation by coordinating cell cycle exit, actin dynamics and survival signaling.
C3G regulates sympathetic preganglionic neuron migration by acting downstream in the reelin (show RELN Antibodies) signaling pathway.
Data indicate that chemical rescue of c-Src provided a tool to dissect the spatiotemporal mechanism of activation of the Rap1 guanine exchange factor, C3G, one of the identified potential c-Src substrates that plays a role in focal adhesion signaling.
GEF and Dlx1/2 form part of a common signalling pathway during GABAergic neuronal development.
Guanine nucleotide releasing factor 2 (show RASGRF2 Antibodies) is a negative regulator of Mitogen-Activated Protein Kinase 14 (show MAPK14 Antibodies) in mouse embryonic fibroblasts and can promote cell survival or cell death depending on the stimuli.
Targeted disruption of Ras-Grf2 (show RASGRF2 Antibodies) shows its dispensability for mouse growth and development.
These results show that C3G is required for (1) vascular myogenesis, (2) the formation of paxillin (show PXN Antibodies)- and integrin beta1-positive, but not integrin beta3-positive, cell adhesions and (3) normal response to PDGF (show PDGFA Antibodies), necessary for vascular myogenesis.
roles of C3G-Rap1 signaling pathway in various biological processes
Our results show that the size of the cortical neural precursor population is controlled by C3G-mediated inhibition of the Ras signalling pathway.
the SSC5:60296617 SNP may affect teat number by regulating the interaction of EPS8 (show EPS8 Antibodies) and RAPGEF1 and, finally, affecting the mammogenesis of pigs
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
CRK SH3-binding GNRP
, guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene)
, rap guanine nucleotide exchange factor 1
, guanine nucleotide releasing factor 2
, guanine nucleotide-releasing factor 2
, Rap guanine nucleotide exchange factor (GEF) 1
, rap guanine nucleotide exchange factor 1-like