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Browse our anti-GRF2 (RAPGEF1) Antibodies

Full name:
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 1 Antibodies (RAPGEF1)
On are 37 Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1) Antibodies from 9 different suppliers available. Additionally we are shipping GRF2 Kits (10) and and many more products for this protein. A total of 52 GRF2 products are currently listed.
4932418O06Rik, B230105J10, c(3)G, C3g, C3G-1, C3G-2, CG3126, CG14436, CG42328, DC3-G, DC3G, Dmel\\CG42328, Dmel_CG3126, Dmel_CG14436, Grf2, rapgef1, zgc:56372
list all antibodies Gene Name GeneID UniProt
RAPGEF1 2889 Q13905
RAPGEF1 107746  
RAPGEF1 63881  

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Most Popular Reactivities for anti-GRF2 (RAPGEF1) Antibodies

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anti-Human GRF2 Antibodies:

anti-Mouse (Murine) GRF2 Antibodies:

anti-Rat (Rattus) GRF2 Antibodies:

All available anti-GRF2 Antibodies

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Top referenced anti-GRF2 Antibodies

  1. Human Monoclonal GRF2 Primary Antibody for ELISA, WB - ABIN395929 : Mitra, Radha: F-actin-binding domain of c-Abl regulates localized phosphorylation of C3G: role of C3G in c-Abl-mediated cell death. in Oncogene 2010 (PubMed)
    Show all 5 references for ABIN395929

  2. Chicken Polyclonal GRF2 Primary Antibody for WB - ABIN2785868 : Martín-Encabo, Santos, Guerrero: C3G mediated suppression of malignant transformation involves activation of PP2A phosphatases at the subcortical actin cytoskeleton. in Experimental cell research 2007 (PubMed)

  3. Human Monoclonal GRF2 Primary Antibody for ELISA, WB - ABIN561125 : Nolz, Nacusi, Segovis, Medeiros, Mitchell, Shimizu, Billadeau: The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1. in The Journal of cell biology 2008 (PubMed)

  4. Human Polyclonal GRF2 Primary Antibody for IHC, ELISA - ABIN1532724 : Humphray, Oliver, Hunt, Plumb, Loveland, Howe, Andrews, Searle, Hunt, Scott, Jones, Ainscough, Almeida, Ambrose, Ashwell, Babbage, Babbage, Bagguley, Bailey, Banerjee, Barker, Barlow, Bates, Beasley et al.: DNA sequence and analysis of human chromosome 9. ... in Nature 2004 (PubMed)

More Antibodies against GRF2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1) interaction partners

  1. C3G stimulates guanine nucleotide exchange on Drosophila Rap (show LRPAP1 Antibodies) GTPases in vitro

  2. the N terminus of C(3)G is critical for the formation of antiparallel pairs of C(3)G homodimers that span the central region and thus for assembly of complete TFs, while the C terminus is required to affix these homodimers to the lateral elements.

Human Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1) interaction partners

  1. C3G/RAP1 activity is involved in the metastatic spread of epithelial ovarian cancer.

  2. C3G plays an important role in platelet clotting through a mechanism involving its GEF (show SLC2A4RG Antibodies) activity and suggest that it might be also involved in neutrophil development.

  3. The possibility of cellular phospho-C3G (pC3G) being a substrate of the intracellular T-cell protein tyrosine phosphatase TC-PTP (show PTPN2 Antibodies) (PTPN2 (show PTPN2 Antibodies)) using the human neuroblastoma (show ARHGEF16 Antibodies) cell line, was studied.

  4. Lyn (show LYN Antibodies) controls spatial activation of Rap1 (show RABGEF1 Antibodies) by recruiting the CrkL (show CRKL Antibodies)-C3G protein complex to the leading edge

  5. found somatic demethylation of a relaxed-criterion CpG island (CGI-B) located in the first intron of RAPGEF1 in 40% of colon cancers and 8% of gastric cancers relative to their matching normal tissues that were always methylated

  6. Data demonstrated that the polymorphism in TP53 (show TP53 Antibodies) (rs1042522) was associated with type 2 diabetes, and that potential interaction of TP53 (show TP53 Antibodies) (rs1042522) and RAPGEF1 (rs11243444), or NRF1 (show NFE2L1 Antibodies) (rs1882095) increased the risk of type 2 diabetes.

  7. significant positive correlation between layers II and IV of the dorso-lateral prefrontal cortex in the percentage of MR-GEF expressing neurons in individuals with bipolar disorder

  8. C3G overexpression induces neurite-like extensions in MDA-MB-231 and BT549 breast carcinoma cells and not in a variety of other cancer cell lines examined.

  9. C3G as a novel target of c-Abl

  10. ALK (show ALK Antibodies) activation of Rap1 (show RABGEF1 Antibodies) via the Rap1 (show RABGEF1 Antibodies)-specific GEF (show SLC2A4RG Antibodies) C3Gmay contribute to cell proliferation and oncogenesis of neuroblastoma (show ARHGEF16 Antibodies).

Mouse (Murine) Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1) interaction partners

  1. results provide evidence that C3G plays an important role in myogenic differentiation by coordinating cell cycle exit, actin dynamics and survival signaling.

  2. C3G regulates sympathetic preganglionic neuron migration by acting downstream in the reelin (show RELN Antibodies) signaling pathway.

  3. Data indicate that chemical rescue of c-Src provided a tool to dissect the spatiotemporal mechanism of activation of the Rap1 guanine exchange factor, C3G, one of the identified potential c-Src substrates that plays a role in focal adhesion signaling.

  4. GEF and Dlx1/2 form part of a common signalling pathway during GABAergic neuronal development.

  5. Guanine nucleotide releasing factor 2 (show RASGRF2 Antibodies) is a negative regulator of Mitogen-Activated Protein Kinase 14 (show MAPK14 Antibodies) in mouse embryonic fibroblasts and can promote cell survival or cell death depending on the stimuli.

  6. Targeted disruption of Ras-Grf2 (show RASGRF2 Antibodies) shows its dispensability for mouse growth and development.

  7. These results show that C3G is required for (1) vascular myogenesis, (2) the formation of paxillin (show PXN Antibodies)- and integrin beta1-positive, but not integrin beta3-positive, cell adhesions and (3) normal response to PDGF (show PDGFA Antibodies), necessary for vascular myogenesis.

  8. roles of C3G-Rap1 signaling pathway in various biological processes

  9. Our results show that the size of the cortical neural precursor population is controlled by C3G-mediated inhibition of the Ras signalling pathway.

  10. C3G regulates cortical neuron migration, preplate splitting and radial glial cell attachment.

GRF2 (RAPGEF1) Antigen Profile

Antigen Summary

This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.

Alternative names and synonyms associated with GRF2 (RAPGEF1)

  • CG42328 gene product from transcript CG42328-RC (C3G) antibody
  • Rap guanine nucleotide exchange factor (GEF) 1 (RAPGEF1) antibody
  • Rap guanine nucleotide exchange factor (GEF) 1 (rapgef1) antibody
  • Rap guanine nucleotide exchange factor (GEF) 1 (Rapgef1) antibody
  • Rap guanine nucleotide exchange factor (GEF) 1b (rapgef1b) antibody
  • Rap guanine nucleotide exchange factor (GEF)-like 1 (Rapgefl1) antibody
  • 4932418O06Rik antibody
  • B230105J10 antibody
  • c(3)G antibody
  • C3g antibody
  • C3G-1 antibody
  • C3G-2 antibody
  • CG3126 antibody
  • CG14436 antibody
  • CG42328 antibody
  • DC3-G antibody
  • DC3G antibody
  • Dmel\\CG42328 antibody
  • Dmel_CG3126 antibody
  • Dmel_CG14436 antibody
  • Grf2 antibody
  • rapgef1 antibody
  • zgc:56372 antibody

Protein level used designations for RAPGEF1

C3G-PC , C3G-PD , C3G-PE , C3G-PF , C3G-PG , C3G-PH , C3G-PI , C3G-PJ , C3G-PK , CG42328-PC , CG42328-PD , CG42328-PE , CG42328-PF , CG42328-PG , CG42328-PH , CG42328-PI , CG42328-PJ , CG42328-PK , guanine nucleotide-releasing factor 2 , rap guanine nucleotide exchange factor 1 , Rap guanine nucleotide exchange factor (GEF) 1 , rap guanine nucleotide exchange factor 1-like , CRK SH3-binding GNRP , guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene) , guanine nucleotide releasing factor 2 , rap guanine nucleotide exchange factor-like 1

31618 Drosophila melanogaster
464812 Pan troglodytes
520454 Bos taurus
733953 Xenopus (Silurana) tropicalis
100402777 Callithrix jacchus
715272 Macaca mulatta
100069527 Equus caballus
100444262 Pongo abelii
100477958 Ailuropoda melanoleuca
100538909 Meleagris gallopavo
100603139 Nomascus leucogenys
2889 Homo sapiens
444199 Xenopus laevis
417173 Gallus gallus
107746 Mus musculus
63881 Rattus norvegicus
100511735 Sus scrofa
394101 Danio rerio
268480 Mus musculus
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