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Browse our RAPGEFL1 Proteins (RAPGEFL1)

Full name:
Rap Guanine Nucleotide Exchange Factor (GEF)-Like 1 Proteins (RAPGEFL1)
On www.antibodies-online.com are 3 Rap Guanine Nucleotide Exchange Factor (GEF)-Like 1 (RAPGEFL1) Proteins from 2 different suppliers available. Additionally we are shipping RAPGEFL1 Antibodies (21) and RAPGEFL1 Kits (9) and many more products for this protein. A total of 34 RAPGEFL1 products are currently listed.
Synonyms:
B230105J10, C3G, DKFZp459G2226, GRF2, Link-GEFII, MGC109414, RAPGEFL1
list all proteins Gene Name GeneID UniProt
Rat RAPGEFL1 RAPGEFL1 303515  
RAPGEFL1 2889 Q13905
RAPGEFL1 268480 Q68EF8

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RAPGEFL1 Proteins (RAPGEFL1) by Origin

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More Proteins for RAPGEFL1 Interaction Partners

Human Rap Guanine Nucleotide Exchange Factor (GEF)-Like 1 (RAPGEFL1) interaction partners

  1. C3G/RAP1 activity is involved in the metastatic spread of epithelial ovarian cancer.

  2. C3G plays an important role in platelet clotting through a mechanism involving its GEF (show SLC2A4RG Proteins) activity and suggest that it might be also involved in neutrophil development.

  3. The possibility of cellular phospho-C3G (pC3G) being a substrate of the intracellular T-cell protein tyrosine phosphatase TC-PTP (show PTPN2 Proteins) (PTPN2 (show PTPN2 Proteins)) using the human neuroblastoma (show ARHGEF16 Proteins) cell line, was studied.

  4. Lyn controls spatial activation of Rap1 by recruiting the CrkL-C3G protein complex to the leading edge

  5. found somatic demethylation of a relaxed-criterion CpG island (CGI-B) located in the first intron of RAPGEF1 in 40% of colon cancers and 8% of gastric cancers relative to their matching normal tissues that were always methylated

  6. Data demonstrated that the polymorphism in TP53 (show TP53 Proteins) (rs1042522) was associated with type 2 diabetes, and that potential interaction of TP53 (show TP53 Proteins) (rs1042522) and RAPGEF1 (rs11243444), or NRF1 (show NFE2L1 Proteins) (rs1882095) increased the risk of type 2 diabetes.

  7. significant positive correlation between layers II and IV of the dorso-lateral prefrontal cortex in the percentage of MR-GEF (show RAPGEF5 Proteins) expressing neurons in individuals with bipolar disorder

  8. C3G overexpression induces neurite-like extensions in MDA-MB-231 and BT549 breast carcinoma cells and not in a variety of other cancer cell lines examined.

  9. C3G as a novel target of c-Abl

  10. ALK activation of Rap1 (show RABGEF1 Proteins) via the Rap1 (show RABGEF1 Proteins)-specific GEF (show SLC2A4RG Proteins) C3Gmay contribute to cell proliferation and oncogenesis of neuroblastoma (show ARHGEF16 Proteins).

RAPGEFL1 Protein Profile

Protein Summary

This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.

Alternative names and synonyms associated with RAPGEFL1

  • Rap guanine nucleotide exchange factor (GEF)-like 1 (Rapgefl1)
  • Rap guanine nucleotide exchange factor (GEF)-like 1 (RAPGEFL1)
  • Rap guanine nucleotide exchange factor (GEF) 1 (RAPGEF1)
  • B230105J10 protein
  • C3G protein
  • DKFZp459G2226 protein
  • GRF2 protein
  • Link-GEFII protein
  • MGC109414 protein
  • RAPGEFL1 protein

Protein level used designations for RAPGEFL1

Rap guanine nucleotide exchange factor (GEF)-like 1 , rap guanine nucleotide exchange factor 1 , CRK SH3-binding GNRP , guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene) , Link guanine nucleotide exchange factor II , RAP guanine-nucleotide-exchange factor (GEF)-like 1 , link GEFII , rap guanine nucleotide exchange factor-like 1

GENE ID SPECIES
303515 Rattus norvegicus
491015 Canis lupus familiaris
745896 Pan troglodytes
100172904 Pongo abelii
491286 Canis lupus familiaris
520454 Bos taurus
2889 Homo sapiens
100511735 Sus scrofa
417173 Gallus gallus
51195 Homo sapiens
268480 Mus musculus
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