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C3G/RAP1 activity is involved in the metastatic spread of epithelial ovarian cancer.
C3G plays an important role in platelet clotting through a mechanism involving its GEF (show SLC2A4RG Proteins) activity and suggest that it might be also involved in neutrophil development.
The possibility of cellular phospho-C3G (pC3G) being a substrate of the intracellular T-cell protein tyrosine phosphatase TC-PTP (show PTPN2 Proteins) (PTPN2 (show PTPN2 Proteins)) using the human neuroblastoma (show ARHGEF16 Proteins) cell line, was studied.
Lyn controls spatial activation of Rap1 by recruiting the CrkL-C3G protein complex to the leading edge
found somatic demethylation of a relaxed-criterion CpG island (CGI-B) located in the first intron of RAPGEF1 in 40% of colon cancers and 8% of gastric cancers relative to their matching normal tissues that were always methylated
Data demonstrated that the polymorphism in TP53 (show TP53 Proteins) (rs1042522) was associated with type 2 diabetes, and that potential interaction of TP53 (show TP53 Proteins) (rs1042522) and RAPGEF1 (rs11243444), or NRF1 (show NFE2L1 Proteins) (rs1882095) increased the risk of type 2 diabetes.
significant positive correlation between layers II and IV of the dorso-lateral prefrontal cortex in the percentage of MR-GEF (show RAPGEF5 Proteins) expressing neurons in individuals with bipolar disorder
C3G overexpression induces neurite-like extensions in MDA-MB-231 and BT549 breast carcinoma cells and not in a variety of other cancer cell lines examined.
C3G as a novel target of c-Abl
ALK activation of Rap1 (show RABGEF1 Proteins) via the Rap1 (show RABGEF1 Proteins)-specific GEF (show SLC2A4RG Proteins) C3Gmay contribute to cell proliferation and oncogenesis of neuroblastoma (show ARHGEF16 Proteins).
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
Rap guanine nucleotide exchange factor (GEF)-like 1
, rap guanine nucleotide exchange factor 1
, CRK SH3-binding GNRP
, guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene)
, Link guanine nucleotide exchange factor II
, RAP guanine-nucleotide-exchange factor (GEF)-like 1
, link GEFII
, rap guanine nucleotide exchange factor-like 1