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promoter SNP rs12899331 of DYX1C1 may contribute towards the manifestation of DD. This study supports the association of DYX1C1 with DD in an Indian population
results demonstrate that DYX1C1 can modulate the expression of genes involved in cell migration and nervous system development and associates with a number of cytoskeletal proteins.
DYX1C1 is required for axonemal dynein assembly and ciliary motility.
The results of this study do not provide evidence for association between the putatively functional single nucleotide polymorphisms -3G/A and 1249G/T in DYX1C1 and reading disabilities.
Gene-by-environment effects were found between some specified environmental moderators (i.e. maternal smoke during pregnancy, birth weight and socio-economic status) and the DYX1C1-1259C/G marker
results suggested that the 931C > T variant in KIAA0319 (show KIAA0319 ELISA Kits), but not the -3G > A in DYX1C1, was significantly associated with the risk of dyslexia
DYX1C1 influences reading development in the general Chinese population and supports a universal effect of this gene.
The results of this study found that DYX1C1 gene contained polymorphisms that were significantly associated with white matter volume in the left temporo-parietal region and that white matter volume influenced reading ability.
Mutations in cilia co-expressed DCDC2 (show DCDC2 ELISA Kits), DYX1C1 and KIAA0319 (show KIAA0319 ELISA Kits) genes are associated with a cognitive neurological disorder, dyslexia.
the expression of DYX1C1 in breast cancer is associated with several clinicopathological parameters and that loss of DYX1C1 correlates with a more aggressive disease, in turn indicating that DYX1C1 is a potential prognostic biomarker in breast cancer.
In dyx1c1 morphants, cilia length is reduced in several organs including Kupffer's vesicle, pronephros, spinal canal and olfactory placode.
This gene encodes a tetratricopeptide repeat domain-containing protein. The encoded protein interacts with estrogen receptors and the heat shock proteins, Hsp70 and Hsp90. An homologous protein in rat has been shown to function in neuronal migration in the developing neocortex. A chromosomal translocation involving this gene is associated with a susceptibility to developmental dyslexia. Mutations in this gene are associated with deficits in reading and spelling. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream cell cycle progression 1 (CCPG1) gene.
dyslexia susceptibility 1 candidate 1
, dyslexia susceptibility 1 candidate gene 1 protein
, Dyslexia susceptibility 1 candidate gene 1 protein homolog
, dyslexia susceptibility 1 candidate 1 homolog
, dyslexia susceptibility 1 candidate gene 1 protein homolog