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the Trip6-GRIP1-myosin VI interaction and its regulation on F-actin network play a significant role in dendritic morphogenesis
In 15 of 590 families, we identified recessive mutations in the genes FRAS1, FREM2, GRIP1 (show NCOA2 Proteins), FREM1, ITGA8, and GREM1 (show GREM1 Proteins), all of which function in the interaction of the ureteric bud and the metanephric mesenchyme.
In three unrelated families with parental consanguinity, GRIP1 (show NCOA2 Proteins) mutations were found to segregate with Fraser syndrome in an autosomal recessive manner.
Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 (show GRIA2 Proteins) recycling and surface distribution in patients with autism
GRIP1 (show NCOA2 Proteins) splice forms interact with gephyrin (show GPHN Proteins) and play a role in synaptic function at GABAergic and glycinergic synapses in cultured hippocampal neurons.
after regulated endocytosis, binding to GRIP/ABP (show ABP1 Proteins) stabilizes the internalized receptors in an intracellular pool and prevents them from being recycled back to the plasma membrane or entering a degradative pathway.
study showed neither single marker nor haplotype analysis revealed an association between variants at GRIP1 (show NCOA2 Proteins) locus & schizophrenia; suggests it is unlikely that the GRIP1 (show NCOA2 Proteins) polymorphisms investigated play a substantial role in schizophrenia susceptibility
Supramodular nature of GRIP1 revealed by the structure of its PDZ12 tandem in complex with the carboxyl tail of Fras1.
Study performed social behavioral testing on neuron-specific Grip1/2-double knockout (DKO) and wild type (WT) mice and determined the expression profile of key signaling proteins in AMPAR, mGluR, mTOR, and GABA pathways in brain. Data Grip1/2-mediated AMPA signaling in regulating social behaviors and disturbance of glutamate- and GABA-signaling in specialized brain regions in autism-related social behavioral deficits.
subcellular redistribution of GRIP1 (show NCOA2 Proteins) and a change in the binding of GRIP1 (show NCOA2 Proteins) to GluA2 (show GRIA2 Proteins) during synaptic scaling, was observed.
This study demonistrated that deletion of accumbal GRIP1 increases vulnerability to cue-induced cocaine relapse without altering the reinforcing properties of the drug or the response to natural rewards
a regulatory role for GRIP1 (show NCOA2 Proteins) during microtubule-based transport and suggest a crucial function for 14-3-3 (show YWHAQ Proteins) proteins in controlling kinesin-1 motor attachment during neuronal development
Data indicate that glucocorticoid receptor (GR (show NR3C1 Proteins)):GRIP1 (show NCOA2 Proteins) use distinct mechanisms to repress inflammatory genes at different stages of the transcription cycle.
GRIP1 (show NCOA2 Proteins) and 2 regulate activity-dependent AMPA (show GRIA3 Proteins) receptor recycling via exocyst complex interactions.
GRIP1 scaffolding protein is required for the formation and integrity of the dermo-epidermal junction and reveal the importance of PDZ domains in the organization of supramolecular structures essential for mammalian embryonic development.
Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites.
morphology of octopus cell (OC) somata in the cochlear nucleus B6 and B6Cast mice, and the immunocytochemistry of GluR1 (show GRIA1 Proteins) (glutamate (show GRIN1 Proteins) receptor subunit 1) and GRIP-C (glutamate (show GRIN1 Proteins) receptor interacting protein (show RIPK1 Proteins)-C (show PROC Proteins) terminus).
investigated whether there is a link between growth inhibitory effect and transcriptional activation of PPARgamma (show PPARG Proteins) in several gastrointestinal tumour cell lines [GRIP1tau]
lactoferrin (show LTF Proteins) and glutamate receptor-interacting protein 1 showed a twofold increase during the controlled internal drug release -induced estrous stage compared to the levels in non-estrous stage in bovine cervical mucus
This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described.
glutamate receptor-interacting protein 1
, eye blebs
, AMPA receptor-interacting protein GRIP1
, glutamate receptor interacting protein 1
, glutamate receptor-interacting protein 1-like