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that HDAC6 is associated physically with the chaperone protein dHsc4/Hsc70 to maintain the proteostasis of PLIN2 (show PLIN2 Proteins)
HDAC6 is necessary and sufficient for BRP (show GDF5 Proteins) deacetylation. HDAC6 promotes the formation of larger presynaptic densities.
Atrial fibrillation induces remodeling and loss of contractile function, at least in part through HDAC6 activation and subsequent derailment of alpha-tubulin (show TUBA4A Proteins) proteostasis and disruption of the cardiomyocyte microtubule structure.
From a genetic screen, we found that a histone deacetylase 6 (HDAC6) null mutation rescued tau-induced MT defects in both muscles and neurons.
Overexpressing any of HDAC 3, 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X tremor ataxia syndrome.
Data suggest that alpha-synuclein inclusion formation in the presence of HDAC6 protects dopamine neurons from being damaged by oligomers, which may uncover a common mechanism for synucleinopathies.
findings suggest that it may be possible to intervene in neurodegeneration by augmenting HDAC6 to enhance autophagy
Findings indicate that HDAC6 facilitates degradation of potentially noxious protein substrates, contributing vitally to the neuroprotective role of autophagy.
Results suggest that atrophin recruits histone deacetylases 1 and 2 and G9a (show EHMT2 Proteins) to modify histone H3K9 and to determine cell fates.
Study detected evidence that recent strongly positive selection has been acting on a 2.7-kb region in an ancestral African population; this region overlaps with the 3' end of HDAC6, a gene that encodes a newly characterized stress surveillance factor.
The HDAC6 Inhibitor Tubacin Induces Release of CD133(+) Extracellular Vesicles From Cancer Cells.
MicroRNA-22 Promoted Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Targeting HDAC6
A decrease of HDAC6 expression caused by Helicobacter pylori infection is associated with oncogenic transformation in gastric cancer.
these results suggest that HDAC1 (show HDAC1 Proteins) and HDAC6 may play a role in clear cell renal cell carcinoma (show MOK Proteins) biology
Genetic abrogation of HDAC6 in primary melanoma (show CD274 Proteins) samples and cell lines, down-regulates the expression of PD-L1, an important co-stimulatory molecule expressed in cancer cells, which activates the inhibitory regulatory pathway PD-1 in T-cells.
activation appears to be a key survival mechanism for HDAC6 inhibitor treatment.
ARID1A mutation inactivates the apoptosis-promoting function of p53 by upregulating HDAC6, indicating that pharmacological inhibition of HDAC6 is a therapeutic strategy for ARID1A-mutated cancers.
7-amino-4-methylcoumarin did not affect acetyllysine preference in a multiply acetylated substrate. In contrast, AMC significantly enhanced KDAC6 substrate affinity, greatly reduced Sirt1 (show SIRT1 Proteins) activity, eliminated the substrate sequence specificity of KDAC4, and had no consistent effect with KDAC8 substrates.
deacetylation of MST1 mediated by HBXIP-enhanced HDAC6 results in MST1 degradation in a chaperone-mediated autophagy (CMA). manner in promotion of breast cancer growth.
Suggest that HDAC4 (show HDAC4 Proteins) and HDAC6 are guardians of irradiation-induced DNA damage and stemness, thus promoting radioresistance in glioblastoma cells.
MAP3K4 (show MAP3K4 Proteins) activity controls epithelial-to-mesenchymal transition through the ubiquitination and degradation of HDAC6.
HDAC6 is a critical regulator of a pro-apoptotic p53 (show TP53 Proteins) K120 acetylation and mitochondrial function in mesenchymal stem cells
HDAC6 inhibition reduces cell growth primarily by reducing intracellular cAMP and Ca(2 (show CA2 Proteins)+) levels.
These data thus reveal that HDAC6 represses IL-17 (show IL17A Proteins) production in T cells, providing novel insights into the role of HDAC6 in the immune system.
HDAC6 inhibition reduces tumor growth and PD-L1 (show CD274 Proteins) production in vivo.
Specific HDAC6 inhibitor, tubacin, reduced cyst growth by inhibiting proliferation of cyst-lining epithelial cells, downregulated cyclic AMP (show TMPRSS5 Proteins) levels, and improved renal function in mouse model of autosomal dominant polycystic kidney disease (ADPKD). Thus, HDAC6 could play a role in cyst formation and could serve as a potential therapeutic target in ADPKD.
Data suggest that a switch in post-translational processing of Tau from acetylation at Lys321 to phosphorylation at Ser324 coordinately regulates Tau aggregation and may be relevant in tauopathy and Alzheimer disease; acetylation/phosphorylation of Tau appears to be controlled by Hdac6 (histone deacetylase 6 protein).
Fatty acids prevent CIDEC (show CIDEC Proteins) deacetylation by promoting the dissociation of CIDEC (show CIDEC Proteins) from HDAC6, resultin in increased association of CIDEC (show CIDEC Proteins) with PCAF (show KAT2B Proteins) on the endoplasmic reticulum.
In coordination with increased HDAC6 phosphorylation, cigarette smoke extract inhibited Akt and activated glycogen synthase kinase (GSK)-3beta.
The results suggest that HSI2 recruits MED13 and HDA6 to suppress directly a subset of seed maturation genes post-germination.
HDA6 is a component of the TRB2 (show TRIB2 Proteins) complex.
Our results indicate that AtMBD6 is involved in RNA-mediated gene silencing and it binds to RNA binding proteins like AtRPS2C, AtAGO4 and AtNTF2. AtMBD6 also interacts with histone deacetylase AtHDA6 that might have a role in chromatin condensation at the targets of RdDM
HDA6 has at least two clearly separable activities in different genomic regions. In addition, we present an unexpected role for HDA6 in the control of DNA methylation (show HELLS Proteins) at CG dinucleotides.
Data show that both transcript levels and expression patterns of ENHANCER OF TRIPTYCHON AND CAPRICE1 (ETC1 (show CD86 Proteins)) in the root tip were affected in hda6 mutation.
HDC1 is a ubiquitously expressed nuclear protein that interacts with at least two deacetylases (HDA6 and HDA19), promotes histone deacetylation, and attenuates derepression of genes under water stress.
HDA6 and FLD (show LPIN1 Proteins) could act together in a protein complex. Increased levels of histone H3 acetylation and H3K4 trimethylation, indicating functional interplay between histone deacetylase and demethylase (show MBD2 Proteins) through HDA6 and FLD (show LPIN1 Proteins) interaction in flowering control.
Taken together, these data indicate that HDA6 is a part of the AS1 repressor complex to regulate the KNOX expression in leaf development.
HD2C functionally associates with HDA6 and regulates gene expression through histone modifications.
HDA6 and MET1 (show DNMT1 Proteins) interact directly and act together to silence transposable elements by modulating DNA methylation (show HELLS Proteins), histone acetylation, and histone methylation status.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
, histone deacetylase 6
, histone deacetylase HDA2
, histone deacetylase 5
, histone deacetylase mHDA2
, scurfy candidate 6