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Each of HSPA4 and MED13 mutations were detected in GC.
Data suggest that MED13, MED12 (show MED12 ELISA Kits), CDK8 (show CDK8 ELISA Kits) and cyclin C (CycC (show CCNC ELISA Kits)) comprise a four-subunit "kinase" module of the Mediator complex that functions as a major ingress of oncogenic and developmental signaling/gene expression in humans. [REVIEW]
Cardiac overexpression of MED13 in transgenic mice confers a lean phenotype that is associated with increased lipid uptake, beta-oxidation and mitochondrial content in white adipose tissue and liver
Med12 (show MED12 ELISA Kits) and Med13 are critical for human CDK8 (show CDK8 ELISA Kits) subcomplex -dependent repression, whereas CDK8 (show CDK8 ELISA Kits) kinase activity is not
MED13 suppressed the expression of genes involved in glucose uptake and metabolism in skeletal muscle by inhibiting the nuclear receptor NURR1 (show NR4A2 ELISA Kits) and the MEF2 (show MEF2C ELISA Kits) transcription factor.
Results delineate a genetic pathway whereby MED13 and miR (show MLXIP ELISA Kits)-208a function in the heart to control whole-body metabolism and unveil a role of the heart in systemic energy homeostasis.
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator.
mediator complex subunit 13
, thyroid hormone receptor associated protein 1
, activator-recruited cofactor 250 kDa component
, mediator of RNA polymerase II transcription subunit 13
, mediator of RNA polymerase II transcription, subunit 13 homolog
, thyroid hormone receptor-associated protein 1
, thyroid hormone receptor-associated protein complex 240 kDa component
, thyroid hormone receptor-associated protein complex component TRAP240
, thyroid hormone receptor-associated protein, 240 kDa subunit
, vitamin D3 receptor-interacting protein complex component DRIP250
, Zmediator complex subunit 13
, mediator of RNA polymerase II transcription, subunit 13
, thyroid hormone receptor associated protein, 240 kDa subunit