Browse our anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) Antibodies

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anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 Antibodies (MLL2)
On www.antibodies-online.com are 35 Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) Antibodies from 10 different suppliers available. Additionally we are shipping Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 Kits (10) and and many more products for this protein. A total of 47 Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 products are currently listed.
Synonyms:
AAD10, ALR, BC032281, BC058659, C430014K11Rik, CAGL114, GSTO1, HRX2, im:7157663, KABUK1, KMS, KMT2B, MLL1B, Mll2, Mll4, TNRC21, TRX2, WBP7
list all antibodies Gene Name GeneID UniProt
MLL2 27100 Q63042
MLL2 9757 Q9UMN6
MLL2 381022  

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Most Popular Reactivities for anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) Antibodies

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Top referenced anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 Antibodies

  1. Human Polyclonal MLL2 Primary Antibody for IHC, ELISA - ABIN184880 : Prasad, Zhadanov, Sedkov, Bullrich, Druck, Rallapalli, Yano, Alder, Croce, Huebner, Mazo, Canaani: Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax. in Oncogene 1997 (PubMed)

  2. Human Monoclonal MLL2 Primary Antibody for ELISA, WB - ABIN948660 : Micale, Augello, Maffeo, Selicorni, Zucchetti, Fusco, De Nittis, Pellico, Mandriani, Fischetto, Boccone, Silengo, Biamino, Perria, Sotgiu, Serra, Lapi, Neri, Ferlini, Cavaliere, Chiurazzi, Monica et al.: Molecular analysis, pathogenic mechanisms, and readthrough therapy on a large cohort of Kabuki syndrome patients. ... in Human mutation 2014 (PubMed)

More Antibodies against Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 Interaction Partners

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) interaction partners

  1. Study shows the contribution of MLL2's methyltransferase and CXXC domain in the trimethylation of H3K4 in embryonic stem cells and find that while it trimethylates H3K4 at both bivalent gene promoters and non-TSS (show RPL38 Antibodies) elements, it regulates transcription at a limited number of genes including those required for primordial germ cell specification.

  2. KMT2D Mutation is associated with esophageal squamous cell carcinoma.

  3. The crucial role of KMT2B in the physiological control of voluntary movement.

  4. MLL1 and MLL2 collaborate to regulate gene expression and leukemia maintenance not through redundancy, but through distinct pathways.

  5. Our findings provide evidence that CHARGE and Kabuki syndromes result from dysregulatrion of CHD7 (show CHD7 Antibodies) and KMT2D genes involved embryonal development that are expressed in a tissue-specific manner.

  6. we demonstrate that low KMT2C and KMT2D expression in biopsies defines better outcome groups in pancreatic ductal adenocarcinoma

  7. MLL4 mutation along with BRCA1 mutation confers chemoresistance in breast cancer.

  8. Pathogenic variants in KMT2D resulting in protein truncation in 43% (6/14; of which 3 are novel) of all cases were detected, while analysis of KDM6A (show KDM6A Antibodies) was negative. MLPA analysis was negative in all instances.

  9. Results show that KMT2B interacts with ERalpha (show ESR1 Antibodies) to bind the ERalpha (show ESR1 Antibodies)-binding sites of IL-20 (show IL20 Antibodies) and other ERalpha (show ESR1 Antibodies) target genes with H3K4 modifications suggesting an important role for KMT2B in the epigenetic transcriptional regulation of cytokine IL-20 (show IL20 Antibodies), and other ERalpha (show ESR1 Antibodies)-responsive genes, in breast cancer cells.

  10. We identify three mosaic missense and likely-gene disrupting mutations in genes previously implicated in ASD (show ARSD Antibodies) (KMT2C, NCKAP1 (show NCKAP1 Antibodies), and MYH10 (show MYH10 Antibodies)) in probands but none in siblings. We find a strong ascertainment bias for mosaic mutations in probands relative to their unaffected siblings

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) interaction partners

  1. MLL4 (show MLL4 Antibodies) deficiency compromised the development of regulatory T cells (Treg cells) and resulted in a substantial decrease in monomethylated H3K4 (H3K4me1) and chromatin interaction at putative gene enhancers, a considerable portion of which were not direct targets of MLL4 (show MLL4 Antibodies) but were enhancers that interacted with MLL4 (show MLL4 Antibodies)-bound sites.

  2. Study shows the contribution of MLL2 (show MLL4 Antibodies)'s methyltransferase and CXXC domain in the trimethylation of H3K4 in embryonic stem cells and find that while it trimethylates H3K4 at both bivalent gene promoters and non-TSS (show RPL38 Antibodies) elements, it regulates transcription at a limited number of genes including those required for primordial germ cell specification.

  3. While H3K4me1 partially supports H3K27ac at active enhancers, it is largely dispensable for transcription. By contrast, Mll3/4 proteins themselves are required for enhancer Pol II loading, eRNA synthesis, and gene expression.

  4. Data from MLL4/KMT2D enzyme-dead knockin ES cells and mice indicate that the enzymatic activity of H3K4 methyltransferase MLL4 (show MLL4 Antibodies) is required for its protein stability.

  5. Although enhancer priming by H3K4me1/2 methyltransferase MLL4/KMT2D is dispensable for cell-identity maintenance, it controls cell fate transition by orchestrating p300 (show NOTCH1 Antibodies)-mediated enhancer activation

  6. KMT2D is essential for regulating cardiac gene expression during heart development primarily via H3K4 di-methylation

  7. MLL2 interacts with RNA polymerase II (RNAPII) and RECQL5, and, although MLL2 mutated cells have normal overall H3K4me levels in genes, nucleosomes in the immediate vicinity of RNAPII are hypomethylated.

  8. MLL4 (KMT2D) is a major H3K4 mono- and di-methyltransferase with partial functional redundancy with MLL3 (KMT2C) in mouse and human cells. MLL4 is enriched on enhancers and is required for enhancer activation, cell-type-specific gene expression and cell differentiation.

  9. Both MLL3 and MLL4 (show MLL4 Antibodies) complexes act as major epigenetic regulators of diverse metabolic processes (including circadian control of bile acid homeostasis).

  10. Mll2 (show MLL4 Antibodies), one of the six Set1 (show SETD1A Antibodies)/Trithorax (show MLLT1 Antibodies)-type H3K4 methyltransferases in mammals, is required for trimethylation of bivalent promoters in mouse embryonic stem cells, whereas Mll1 is redundant.

Pig (Porcine) Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) interaction partners

  1. MLL2 is essential for porcine embryo development by the regulation of methylation of H3K4 in vitro.

Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) Antigen Profile

Antigen Summary

The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome.

Alternative names and synonyms associated with Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2)

  • lysine (K)-specific methyltransferase 2D (kmt2d) antibody
  • glutathione S-transferase omega-1-like (LOC785216) antibody
  • growth factor, augmenter of liver regeneration (Gfer) antibody
  • lysine (K)-specific methyltransferase 2B (KMT2B) antibody
  • lysine (K)-specific methyltransferase 2D (Kmt2d) antibody
  • lysine (K)-specific methyltransferase 2D (KMT2D) antibody
  • myeloid/lymphoid or mixed-lineage leukemia 2 (MLL2) antibody
  • myeloid/lymphoid or mixed-lineage leukemia 2-like (Mll2l) antibody
  • AAD10 antibody
  • ALR antibody
  • BC032281 antibody
  • BC058659 antibody
  • C430014K11Rik antibody
  • CAGL114 antibody
  • GSTO1 antibody
  • HRX2 antibody
  • im:7157663 antibody
  • KABUK1 antibody
  • KMS antibody
  • KMT2B antibody
  • MLL1B antibody
  • Mll2 antibody
  • Mll4 antibody
  • TNRC21 antibody
  • TRX2 antibody
  • WBP7 antibody

Protein level used designations for MLL2

myeloid/lymphoid or mixed-lineage leukemia 2 , glutathione S-transferase omega 1 , FAD-linked sulfhydryl oxidase ALR , augmenter of liver regeneration , growth factor, erv1 homolog , growth factor, erv1-like (augmenter of liver regeneration) , KMT2D , WBP-7 , WW domain binding protein 7 , WW domain-binding protein 7 , histone-lysine N-methyltransferase 2B , histone-lysine N-methyltransferase MLL4 , lysine N-methyltransferase 2B , lysine N-methyltransferase 2D , mixed lineage leukemia gene homolog 2 , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 4 , myeloid/lymphoid or mixed-lineage leukemia 4 , myeloid/lymphoid or mixed-lineage leukemia protein 4 , trithorax homolog 2 , trithorax homologue 2 , ALL1-related protein , histone-lysine N-methyltransferase 2D , histone-lysine N-methyltransferase MLL2 , myeloid/lymphoid or mixed-lineage leukemia protein 2 , Kabuki make-up syndrome , Kabuki mental retardation syndrome , trinucleotide repeat containing 21

GENE ID SPECIES
100158249 Danio rerio
785216 Bos taurus
27100 Rattus norvegicus
9757 Homo sapiens
381022 Mus musculus
8085 Homo sapiens
506805 Bos taurus
100512962 Sus scrofa
486558 Canis lupus familiaris
425846 Gallus gallus
362996 Rattus norvegicus
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