Browse our Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) ELISA Kits

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Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 ELISA Kits (MLL2)
On www.antibodies-online.com are 10 Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) ELISA Kits from 1 different suppliers available. Additionally we are shipping Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 Antibodies (35) and and many more products for this protein. A total of 47 Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 products are currently listed.
Synonyms:
AAD10, ALR, BC032281, BC058659, C430014K11Rik, CAGL114, GSTO1, HRX2, im:7157663, KABUK1, KMS, KMT2B, MLL1B, Mll2, Mll4, TNRC21, TRX2, WBP7
list all ELISA KIts Gene Name GeneID UniProt
MLL2 27100 Q63042
MLL2 9757 Q9UMN6
MLL2 381022  

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More ELISA Kits for Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 Interaction Partners

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) interaction partners

  1. Three of four cases of histiocytic sarcoma had alterations in the KMT2D gene.

  2. Study shows the contribution of MLL2's methyltransferase and CXXC domain in the trimethylation of H3K4 in embryonic stem cells and find that while it trimethylates H3K4 at both bivalent gene promoters and non-TSS (show RPL38 ELISA Kits) elements, it regulates transcription at a limited number of genes including those required for primordial germ cell specification.

  3. KMT2D Mutation is associated with esophageal squamous cell carcinoma.

  4. The crucial role of KMT2B in the physiological control of voluntary movement.

  5. MLL1 and MLL2 collaborate to regulate gene expression and leukemia maintenance not through redundancy, but through distinct pathways.

  6. Our findings provide evidence that CHARGE and Kabuki syndromes result from dysregulatrion of CHD7 (show CHD7 ELISA Kits) and KMT2D genes involved embryonal development that are expressed in a tissue-specific manner.

  7. we demonstrate that low KMT2C and KMT2D expression in biopsies defines better outcome groups in pancreatic ductal adenocarcinoma

  8. MLL4 mutation along with BRCA1 mutation confers chemoresistance in breast cancer.

  9. Pathogenic variants in KMT2D resulting in protein truncation in 43% (6/14; of which 3 are novel) of all cases were detected, while analysis of KDM6A (show KDM6A ELISA Kits) was negative. MLPA analysis was negative in all instances.

  10. Results show that KMT2B interacts with ERalpha (show ESR1 ELISA Kits) to bind the ERalpha (show ESR1 ELISA Kits)-binding sites of IL-20 (show IL20 ELISA Kits) and other ERalpha (show ESR1 ELISA Kits) target genes with H3K4 modifications suggesting an important role for KMT2B in the epigenetic transcriptional regulation of cytokine IL-20 (show IL20 ELISA Kits), and other ERalpha (show ESR1 ELISA Kits)-responsive genes, in breast cancer cells.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) interaction partners

  1. UTX (show KDM6A ELISA Kits)-MLL4 (show MLL4 ELISA Kits)-p300 (show NOTCH1 ELISA Kits) transcriptional regulatory network establishing an "active enhancer landscape" and defines a detailed mechanism for the joint deposition of H3K4me1 and H3K27ac.

  2. MLL4 (show MLL4 ELISA Kits) deficiency compromised the development of regulatory T cells (Treg cells) and resulted in a substantial decrease in monomethylated H3K4 (H3K4me1) and chromatin interaction at putative gene enhancers, a considerable portion of which were not direct targets of MLL4 (show MLL4 ELISA Kits) but were enhancers that interacted with MLL4 (show MLL4 ELISA Kits)-bound sites.

  3. Study shows the contribution of MLL2 (show MLL4 ELISA Kits)'s methyltransferase and CXXC domain in the trimethylation of H3K4 in embryonic stem cells and find that while it trimethylates H3K4 at both bivalent gene promoters and non-TSS (show RPL38 ELISA Kits) elements, it regulates transcription at a limited number of genes including those required for primordial germ cell specification.

  4. While H3K4me1 partially supports H3K27ac at active enhancers, it is largely dispensable for transcription. By contrast, Mll3/4 proteins themselves are required for enhancer Pol II loading, eRNA synthesis, and gene expression.

  5. Data from MLL4/KMT2D enzyme-dead knockin ES cells and mice indicate that the enzymatic activity of H3K4 methyltransferase MLL4 (show MLL4 ELISA Kits) is required for its protein stability.

  6. Although enhancer priming by H3K4me1/2 methyltransferase MLL4/KMT2D is dispensable for cell-identity maintenance, it controls cell fate transition by orchestrating p300 (show NOTCH1 ELISA Kits)-mediated enhancer activation

  7. KMT2D is essential for regulating cardiac gene expression during heart development primarily via H3K4 di-methylation

  8. MLL2 interacts with RNA polymerase II (RNAPII) and RECQL5, and, although MLL2 mutated cells have normal overall H3K4me levels in genes, nucleosomes in the immediate vicinity of RNAPII are hypomethylated.

  9. MLL4 (KMT2D) is a major H3K4 mono- and di-methyltransferase with partial functional redundancy with MLL3 (KMT2C) in mouse and human cells. MLL4 is enriched on enhancers and is required for enhancer activation, cell-type-specific gene expression and cell differentiation.

  10. Both MLL3 and MLL4 (show MLL4 ELISA Kits) complexes act as major epigenetic regulators of diverse metabolic processes (including circadian control of bile acid homeostasis).

Pig (Porcine) Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) interaction partners

  1. MLL2 is essential for porcine embryo development by the regulation of methylation of H3K4 in vitro.

Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2) Antigen Profile

Antigen Summary

The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome.

Alternative names and synonyms associated with Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2)

  • lysine (K)-specific methyltransferase 2D (kmt2d) Elisa Kit
  • glutathione S-transferase omega-1-like (LOC785216) Elisa Kit
  • growth factor, augmenter of liver regeneration (Gfer) Elisa Kit
  • lysine (K)-specific methyltransferase 2B (KMT2B) Elisa Kit
  • lysine (K)-specific methyltransferase 2D (Kmt2d) Elisa Kit
  • lysine (K)-specific methyltransferase 2D (KMT2D) Elisa Kit
  • myeloid/lymphoid or mixed-lineage leukemia 2 (MLL2) Elisa Kit
  • myeloid/lymphoid or mixed-lineage leukemia 2-like (Mll2l) Elisa Kit
  • AAD10 Elisa Kit
  • ALR Elisa Kit
  • BC032281 Elisa Kit
  • BC058659 Elisa Kit
  • C430014K11Rik Elisa Kit
  • CAGL114 Elisa Kit
  • GSTO1 Elisa Kit
  • HRX2 Elisa Kit
  • im:7157663 Elisa Kit
  • KABUK1 Elisa Kit
  • KMS Elisa Kit
  • KMT2B Elisa Kit
  • MLL1B Elisa Kit
  • Mll2 Elisa Kit
  • Mll4 Elisa Kit
  • TNRC21 Elisa Kit
  • TRX2 Elisa Kit
  • WBP7 Elisa Kit

Protein level used designations for MLL2

myeloid/lymphoid or mixed-lineage leukemia 2 , glutathione S-transferase omega 1 , FAD-linked sulfhydryl oxidase ALR , augmenter of liver regeneration , growth factor, erv1 homolog , growth factor, erv1-like (augmenter of liver regeneration) , KMT2D , WBP-7 , WW domain binding protein 7 , WW domain-binding protein 7 , histone-lysine N-methyltransferase 2B , histone-lysine N-methyltransferase MLL4 , lysine N-methyltransferase 2B , lysine N-methyltransferase 2D , mixed lineage leukemia gene homolog 2 , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 4 , myeloid/lymphoid or mixed-lineage leukemia 4 , myeloid/lymphoid or mixed-lineage leukemia protein 4 , trithorax homolog 2 , trithorax homologue 2 , ALL1-related protein , histone-lysine N-methyltransferase 2D , histone-lysine N-methyltransferase MLL2 , myeloid/lymphoid or mixed-lineage leukemia protein 2 , Kabuki make-up syndrome , Kabuki mental retardation syndrome , trinucleotide repeat containing 21

GENE ID SPECIES
100158249 Danio rerio
785216 Bos taurus
27100 Rattus norvegicus
9757 Homo sapiens
381022 Mus musculus
8085 Homo sapiens
506805 Bos taurus
100512962 Sus scrofa
486558 Canis lupus familiaris
425846 Gallus gallus
362996 Rattus norvegicus
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