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Browse our Histone-Lysine N-Methyltransferase MLL4 (MLL4) ELISA Kits

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Histone-Lysine N-Methyltransferase MLL4 ELISA Kits (MLL4)
On are 10 Histone-Lysine N-Methyltransferase MLL4 (MLL4) ELISA Kits from 1 different suppliers available. Additionally we are shipping Histone-Lysine N-Methyltransferase MLL4 Antibodies (32) and many more products for this protein. A total of 46 Histone-Lysine N-Methyltransferase MLL4 products are currently listed.
2610014H22Rik, ALR, BC032281, BC058659, C430014K11Rik, HRX2, KMT2B, mKIAA0304, MLL1B, Mll2, Mll4, RGD1308331, TRX2, Wbp7
list all ELISA KIts Gene Name GeneID UniProt
MLL4 9757 Q9UMN6
MLL4 361543  
MLL4 75410 O08550

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More ELISA Kits for Histone-Lysine N-Methyltransferase MLL4 Interaction Partners

Human Histone-Lysine N-Methyltransferase MLL4 (MLL4) interaction partners

  1. Results show that KMT2B (show MLL2 ELISA Kits) interacts with ERalpha (show ESR1 ELISA Kits) to bind the ERalpha (show ESR1 ELISA Kits)-binding sites of IL-20 (show IL20 ELISA Kits) and other ERalpha (show ESR1 ELISA Kits) target genes with H3K4 modifications suggesting an important role for KMT2B (show MLL2 ELISA Kits) in the epigenetic transcriptional regulation of cytokine IL-20 (show IL20 ELISA Kits), and other ERalpha (show ESR1 ELISA Kits)-responsive genes, in breast cancer cells.

  2. findings thus establish generalized dystonia as the human phenotype associated with haploinsufficiency of KMT2B (show MLL2 ELISA Kits); moreover, we provide evidence for a causative role of disordered histone modification, chromatin states, and transcriptional deregulation in dystonia pathogenesis

  3. The results explain how the MLL (show MLL ELISA Kits) SET domains of MLL1 and MLL4 (show MLL2 ELISA Kits) are able to add multiple methyl groups to the target histone H3 (show HIST3H3 ELISA Kits) lysine.

  4. The Aven (show AVEN ELISA Kits) RGG/RG motif bound G4 structures within the coding regions of the MLL1 and MLL4 (show MLL2 ELISA Kits) mRNAs increasing their polysomal association and translation, resulting in the induction of transcription of leukemic genes.

  5. We propose that MLL3 and MLL4 (show MLL2 ELISA Kits) are broadly required for controlling MAFA (show KLRG1 ELISA Kits) and MAFB (show MAFB ELISA Kits) transactivation during development and postnatally.

  6. HBV-MLL4 (show MLL2 ELISA Kits) integration occurred frequently in Chinese HCC (show FAM126A ELISA Kits) patients, representing a unique molecular segment for HCC (show FAM126A ELISA Kits) with HBV infection

  7. Chromosomal translocation in a pediatric undifferentiated spindle cell sarcoma have characterized this alteration to show rearrangement of the MLL4 (show MLL2 ELISA Kits) and GPS2 (show GPS2 ELISA Kits) genes, resulting in fusion gene MLL4 (show MLL2 ELISA Kits)-GPS2 (show GPS2 ELISA Kits), the expression of which promotes independent growth.

  8. KMT2B (show MLL2 ELISA Kits) transgene mediates hippocampal histone 3 lysine 4 di- and trimethylation and is a critical player for memory formation.

  9. the second PHD finger (PHD2) of MLL1 is an E3 ubiquitin ligase in the presence of the E2-conjugating enzyme CDC34. This activity is conserved in the second PHD finger of MLL4, the closest homolog to MLL1 but not in MLL2 or MLL3.

  10. knockdown of MLL4 (show MLL2 ELISA Kits) severely affects cell-cycle progression and induces apoptotic cell death in cultured tumour cells.

Mouse (Murine) Histone-Lysine N-Methyltransferase MLL4 (MLL4) interaction partners

  1. Data from MLL4/KMT2D (show MLL2 ELISA Kits) enzyme-dead knockin ES cells and mice indicate that the enzymatic activity of H3K4 methyltransferase MLL4 is required for its protein stability.

  2. Although enhancer priming by H3K4me1/2 methyltransferase MLL4/KMT2D (show MLL2 ELISA Kits) is dispensable for cell-identity maintenance, it controls cell fate transition by orchestrating p300 (show NOTCH1 ELISA Kits)-mediated enhancer activation

  3. KMT2D (show MLL2 ELISA Kits) is essential for regulating cardiac gene expression during heart development primarily via H3K4 di-methylation

  4. MLL2 interacts with RNA polymerase II (RNAPII) and RECQL5, and, although MLL2 mutated cells have normal overall H3K4me levels in genes, nucleosomes in the immediate vicinity of RNAPII are hypomethylated.

  5. MLL4 (KMT2D) is a major H3K4 mono- and di-methyltransferase with partial functional redundancy with MLL3 (KMT2C) in mouse and human cells. MLL4 is enriched on enhancers and is required for enhancer activation, cell-type-specific gene expression and cell differentiation.

  6. The results reveal a critical role for Mll2 in proliferation and cardiac lineage differentiation of mouse ESCs (show NR2E3 ELISA Kits), and provide novel molecular insight into the mechanisms of cardiac development and disease.

  7. Both MLL3 and MLL4 complexes act as major epigenetic regulators of diverse metabolic processes (including circadian control of bile acid homeostasis).

  8. Mll2, one of the six Set1/Trithorax-type H3K4 methyltransferases in mammals, is required for trimethylation of bivalent promoters in mouse embryonic stem cells, whereas Mll1 is redundant.

  9. results demonstrate that histone H3K4 methyltransferase Mll2 is a component of the genetic regulation necessary for glucose homeostasis, resulting in a specific disease pattern linking chromatin modification with causes and progression of type 2 diabetes

  10. Identify Mll2 (KMT2b) as the enzyme catalyzing H3K4 trimethylation at bivalently marked promoters in embryonic stem cells. Mll2 is required for H3K4 trimethylation at Homeobox (show PRRX1 ELISA Kits) gene clusters.

Histone-Lysine N-Methyltransferase MLL4 (MLL4) Antigen Profile

Antigen Summary

This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known.

Alternative names and synonyms associated with Histone-Lysine N-Methyltransferase MLL4 (MLL4)

  • lysine (K)-specific methyltransferase 2B (KMT2B) Elisa Kit
  • lysine (K)-specific methyltransferase 2B (Kmt2b) Elisa Kit
  • lysine (K)-specific methyltransferase 2D (Kmt2d) Elisa Kit
  • myeloid/lymphoid or mixed-lineage leukemia 4 (MLL4) Elisa Kit
  • myeloid/lymphoid or mixed-lineage leukemia 4 (LOC100353483) Elisa Kit
  • 2610014H22Rik Elisa Kit
  • ALR Elisa Kit
  • BC032281 Elisa Kit
  • BC058659 Elisa Kit
  • C430014K11Rik Elisa Kit
  • HRX2 Elisa Kit
  • KMT2B Elisa Kit
  • mKIAA0304 Elisa Kit
  • MLL1B Elisa Kit
  • Mll2 Elisa Kit
  • Mll4 Elisa Kit
  • RGD1308331 Elisa Kit
  • TRX2 Elisa Kit
  • Wbp7 Elisa Kit

Protein level used designations for MLL4

KMT2D , WBP-7 , WW domain binding protein 7 , WW domain-binding protein 7 , histone-lysine N-methyltransferase 2B , histone-lysine N-methyltransferase MLL4 , lysine N-methyltransferase 2B , lysine N-methyltransferase 2D , mixed lineage leukemia gene homolog 2 , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 4 , myeloid/lymphoid or mixed-lineage leukemia 4 , myeloid/lymphoid or mixed-lineage leukemia protein 4 , trithorax homolog 2 , trithorax homologue 2 , mixed lineage leukemia 2 , myeloid/lymphoid or mixed-lineage leukemia protein 4 homolog , ALL1-related protein , histone-lysine N-methyltransferase 2D , histone-lysine N-methyltransferase MLL2 , myeloid/lymphoid or mixed-lineage leukemia 2 , myeloid/lymphoid or mixed-lineage leukemia protein 2

9757 Homo sapiens
361543 Rattus norvegicus
75410 Mus musculus
381022 Mus musculus
100688666 Canis lupus familiaris
100353483 Oryctolagus cuniculus
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