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NCOA4 acts as a regulator of DNA replication origins that helps prevent inappropriate DNA synthesis and replication stress.
Ubiquitin-dependent NCOA4 turnover is promoted by excess iron and involves an iron-dependent interaction between NCOA4 and the HERC2 ubiquitin ligase.
Studies indicate nuclear receptor coactivator 4 (NcoA4) as a coactivator for a variety of nuclear receptors.
provide a new mechanism for selective autophagy of ferritin (show FTL ELISA Kits) and reveal a previously unappreciated role for autophagy and NCOA4 in the control of iron homeostasis in vivo
RET (show RET ELISA Kits)/PTC3 gene rearrangements are the most prevalent form of rearrangements in papillary thyroid carcinomas of Chennai population.
identification of NCOA4 as a selective cargo receptor for autophagic turnover of ferritin (show FTL ELISA Kits) (ferritinophagy), which is critical for iron homeostasis, and provides a resource for further dissection of autophagosomal cargo-receptor connectivity
mechanism dissection shows that KLK2 (show KLK2 ELISA Kits) may cooperate with the AR coregulator, ARA70, to enhance AR transactivation that may result in alteration of prostate cancer formation
Data indicate that the increase in prostate cancer (PC) risk associated with rs10993994:C>T is likely mediated by the variant's effect of MSMB (show MSMB ELISA Kits)-encoded protein PSP94 (show MSMB ELISA Kits) expression; however, this effect does not extend to NCOA4 in the data.
Computational network analysis reveals that the MSMB (show MSMB ELISA Kits) gene is functionally connected to NCOA4 and the androgen receptor (show AR ELISA Kits) signaling pathway. The data provide an example of how GWAS-associated variants may have multiple genetic and epigenetic effects
Suppression of MSMB (show MSMB ELISA Kits) expression or NCOA4 overexpression promotes anchorage-independent growth of prostate epithelial cells.
NCOA4 prevents iron accumulation and ensures efficient erythropoiesis, playing a central role in balancing iron levels in vivo.
Results demonstrate ubiquitous NcoA4 expression throughout development and suggest that this coactivator may play a role in modulating nuclear receptor activity, particularly that of the aryl hydrocarbon receptor (show AHR ELISA Kits), during development.
Data suggest that myostatin (show MSTN ELISA Kits) decreases the activity of androgen receptors (AR) by down-regulating the expression of ARA70, a known stimulating co-factor of AR
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14.
nuclear receptor coactivator 4
, Nuclear receptor coactivator 4
, 70 kDa AR-activator
, 70 kDa androgen receptor coactivator
, RET-activating gene ELE1
, androgen receptor-associated protein of 70 kDa
, ret fused