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Human Monoclonal NKX2-1 Primary Antibody for FACS, IHC (p) - ABIN1688762
Vyberg, Nielsen: Proficiency testing in immunohistochemistry-experiences from Nordic Immunohistochemical Quality Control (NordiQC). in Virchows Archiv : an international journal of pathology 2016
Show all 5 Pubmed References
We demonstrated that the 14q13.2q21.1 deletion, which encompasses NKX2-1, but not FOXG1 (show FOXG1 Antibodies) gene and HPE8 region, identifies a well defined, more benign, microdeletion syndrome
The genetic or epigenetic inactivation of NKX2-1/TTF-1 may play an essential role in the development and aberrant differentiation of non-TRU-type lung adenocarcinomas.
Findings suggest that the novel non-transcriptional function of TTF-1 identified in this study may contribute to lung adenocarcinoma development by conferring tolerance to DNA RS, which is known to be inherently elicited by activation of various oncogenes.
Immunohistochemical detection of thyroid transcription factor 1, Napsin A (show NAPSA Antibodies), and P40 (show IL9 Antibodies) fragment of TP63 (show TP63 Antibodies) can be used in the subclassification of non-small cell lung carcinomas.
The rate of TTF-1-positive circulating tumor cells was strongly correlated with TNM (show ODZ1 Antibodies) staging, vascular infiltration, lymphatic metastasis, and the levels of CA125 (show MUC16 Antibodies), CA15.3, and HE4 (show WFDC2 Antibodies) in endometrial carcinoma.
Study postulated that both TTF-1 and PAX-8 (show PAX8 Antibodies) when co-expressed and have anti-proliferative and anti-tumorigenic properties up to a threshold expression level and beyond that, are able to induce pro-tumorigenic effects in thyroid carcinomas.
Results suggest that the thyroid transcription factor 1 expression was independently associated with progression-free survival and overall survival in patients with advanced-stage non-squamous non-small cell lung cancer treated with pemetrexed-based chemotherapy.
These findings describe recurrent NKX2-1 mutations in invasive mucinous adenocarcinomas of the lung and support NKX2-1 as a lineage-specific tumor suppressor gene in lung carcinogenesis.
Report TTF1 expression is common in combined Merkel cell carcinoma.
Preoperative serum miR (show MLXIP Antibodies)-365 and TTF-1 mRNA levels may be effective indicators of tumor aggressiveness in human NSCLC. miR (show MLXIP Antibodies)-365 and its target gene TTF-1 appear to be synergistic risk factors for the reduction in overall survival of patients with NSCLC.
NKX2-1 binding at distal regulatory elements led to a repressed epigenetic state and transcriptional repression in the ventricular zone. Conversely, NKX2-1 is required to establish a permissive chromatin state and transcriptional activation in the sub-ventricular and mantle zones.
Skin differentiation is impaired, and both apoptosis and cell proliferation are augmented in the absence of p23 (show CDK5R1 Antibodies); the consequences are a severe thinning of the stratum corneum and reduced numbers of hair follicles. Since the phenotype of p23 (show CDK5R1 Antibodies)-null embryos is strikingly similar to that of embryos lacking the glucocorticoid receptor (show NR3C1 Antibodies), a paradigmatic Hsp90 (show HSP90 Antibodies)-p23 (show CDK5R1 Antibodies) client protein, we investigated glucocorticoid signaling.
Study shows that within the NANCI-Nkx2.1 duplex, NANCI plays an essential role in regulating tissue identity by acting as a transcriptional rheostat to buffer Nkx2.1 expression. During lung development and in adult lung homeostasis, NANCI acts in cis (show CISH Antibodies) to positively regulate Nkx2.1, and, in turn, Nkx2.1 directly inhibits NANCI expression.
Results identified two proteins P23 (show CDK5R1 Antibodies) and HCLS1 (show HCLS1 Antibodies), which were not known as RNA-binding proteins, exhibiting RNA-binding activity.
data indicate that TTF-1 interacts with PPFP to inhibit the pro-adipogenic response to pioglitazone, and that the ability of pioglitazone to decrease TTF-1 expression contributes to its pro-adipogenic action.
Identify regulatory link between Nkx2-1, miR (show MLXIP Antibodies)-200c, and the transcription factors Nfib (show NFIB Antibodies) and Myb (show MYB Antibodies), adding new players to the regulatory mechanisms driven by Nkx2-1 in lung epithelial cells that may have implications in lung development and tumorigenesis.
A population of neural stem cells in the ventral region of the adult ventricular-subventricular zone expresses the transcription factor Nkx2.1 and is derived from Nkx2.1-expressing (Nkx2.1+) embryonic precursors.
We conclude that a dedicated subset of VMHVL neurons marked by ERalpha (show ESR1 Antibodies), NKX2-1, and Tac1 (show TAC1 Antibodies) regulates estrogen-dependent fluctuations in physical activity and constitutes one of several neuroendocrine modules that drive sex-specific responses.
Prototypic GPe (show GYPE Antibodies) neurons derive from the medial ganglionic eminence of the embryonic subpallium and express the transcription factor Nkx2-1. These neurons fire at high rates during alert rest, and encode movements through heterogeneous firing rate changes.
Molecular characterization of disseminated tumor cells indicates that downregulation of the transcription factor Nkx2-1 precedes lung adenocarcinoma dissemination.
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TFF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription.
thyroid transcription factor 1
, NK2 homeobox 1
, NK-2 homolog A
, homeobox protein NK-2 homolog A
, homeobox protein Nkx-2.1
, thyroid nuclear factor 1
, thyroid-specific enhancer-binding protein
, thyroid transcription factor 1 TTF-1 NK-2
, thyroid transcription factor-1
, homeodomain protein NKx2.1
, cytosolic prostaglandin E2 synthase
, hsp90 co-chaperone
, p23 cochaperone
, progesterone receptor complex p23
, prostaglandin E synthase 3
, sid 3177
, telomerase binding protein, p23
, telomerase-binding protein p23