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anti-Rat (Rattus) Nodal Antibodies:
anti-Mouse (Murine) Nodal Antibodies:
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these results therefore highlight an unanticipated role for p53 (show TP53 Antibodies) family proteins in a regulatory network that integrates essential Wnt (show WNT2 Antibodies)-Tcf (show HNF4A Antibodies) and nodal-Smad (show SMAD1 Antibodies) inputs.
In the presence of a Nodal heterozygous mutation mice lacking both Tgif1 (show TGIF1 Antibodies) and its paralog, Tgif2 (show TGIF2 Antibodies), survive to late gestation.
PGAP6 plays a critical role in Nodal signaling modulation through CRIPTO (show TDGF1 Antibodies) shedding.
results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty (show LEFTY2 Antibodies)-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A (show DNMT3A Antibodies) and DNMT3B (show DNMT3B Antibodies); findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation (show HELLS Antibodies) and demethylation crucial to regulation of key signalling pathways in early body plan formation
Results indicate that microRNA miR (show MLXIP Antibodies)-127 accelerates mesendoderm differentiation of embryonic stem cells through nodal signaling by targeting left-right determination factor 2 (Lefty2 (show LEFTY2 Antibodies)).
The finding that Foxh1 (show FOXH1 Antibodies)-Grg (show AES Antibodies)-mediated repression is not essential for Nodal expression during mouse embryogenesis suggests that other regulators compensate for the loss of repressive regulatory input that is mediated by Grg (show AES Antibodies) interactions.
The Nodal morphogen (show SHH Antibodies) gradient induces distinct gene expression patterns during zebrafish embryogenesis.
HEB (show FREM1 Antibodies) is a fundamental link between Nodal signalling, the derepression of a specific class of poised promoters during differentiation, and lineage specification in mouse embryonic stem cells
Studies indicate that the pair of Nodal and Lefty (Lefty1 and Lefty2 (show LEFTY2 Antibodies)) has a conserved role in left-right asymmetry.
Studies indicate that Nodal/Smad2 (show SMAD2 Antibodies)-dependent signals govern initial proximal-distal polarity and formation of the anterior visceral endoderm (AVE).
n this work, we report two patients with a DAND5 (show DAND5 Antibodies) heterozygous non-synonymous variant (c.455G > A) in the functional domain of the DAND5 (show DAND5 Antibodies) protein (p.R152H), a master regulator of Nodal signaling. Patient 1 presents left isomerism, ventricular septal defect with overriding aorta and pulmonary atresia, while patient 2 presents ventricular septal defect with overriding aorta, right ventricular hypertrophy
Together SMAD3 (show SMAD3 Antibodies) and ZIC2 (show ZIC2 Antibodies) regulate FOXA2 (show FOXA2 Antibodies) transcription in cultured cells and Zic2 (show ZIC2 Antibodies) also controls the foxA2 (show FOXA2 Antibodies) expression during Xenopus development. These findings reveal a new mechanism of NODAL signal transduction in the mammalian node and provide the first molecular explanation of how ZIC2 (show ZIC2 Antibodies) loss-of-function precipitates Holoprosencephaly (HPE
Data show that BRAF (show BRAF Antibodies) inhibitor (BRAFi) treatment failed to affect Nodal protein levels in melanoma tissues.
Oct-4 (show POU5F1 Antibodies) signaling is modulated by nodal via nuclear translocation of beta-catenin (show CTNNB1 Antibodies) in lung and prostate cancer cells
patients with tumors in which both Nodal and YAP1 (show YAP1 Antibodies) were expressed at high levels had the worst prognosis
The MSX2 controls mesendoderm lineage commitment by simultaneous suppression of SOX2 (show SOX2 Antibodies) and induction of NODAL expression through direct binding and activation of the Nodal promoter.
During a maturation phase, a fast acting NODAL loop stimulates its own activity and temporarily inhibits BMP signaling. During the stabilization phase, a slow acting NODAL loop, involving WNTs re-establishes BMP signaling and the pluripotency circuitry.
Nodal signaling pathway has subtle changes in the endometrium of women with endometriosis, but this imbalance may not cause functional damage as it seems not to affect the nuclear expression of SMAD4 (show SMAD4 Antibodies).
The expression of lefty (show LEFTY2 Antibodies) in RCC (show XRCC1 Antibodies) cells was lower than that in adjacent non-tumor cells, which may result in the overexpression of nodal, thereby promoting the growth of RCC (show XRCC1 Antibodies).
FoxH1 (show FOXH1 Antibodies) and Grg4 (show TLE4 Antibodies) occupy the Xnr1 enhancer, and Grg4 (show TLE4 Antibodies) occupancy is dependent on the FoxH1 (show FOXH1 Antibodies) EH1 (show EPHX1 Antibodies) motif. Grg4 (show TLE4 Antibodies) occupancy at the Xnr1 enhancer significantly decreases with Nodal activation or Smad2 (show SMAD2 Antibodies) overexpression, while FoxH1 (show FOXH1 Antibodies) occupancy is unaffected. These results suggest that Nodal-activated Smad2 (show SMAD2 Antibodies) physically displaces Grg4 (show TLE4 Antibodies) from FoxH1 (show FOXH1 Antibodies), an essential feature of the transcriptional switch mechanism.
Data show taht combined Wnt (show WNT2 Antibodies) and Nodal signaling synergistically activates transcription of Spemann organizer genes.
Data suggest that Coco (show DAND5 Antibodies) acts as a critical target of flow, suggesting that symmetry is broken by flow-mediated left-asymmetric release of Nodal repression at the midline.
Data show that rapid differential transport of Nodal and Lefty (show LEFTY2 Antibodies) on sulfated (show SULF1 Antibodies) proteoglycan (show Vcan Antibodies)-rich extracellular matrix regulates left-right asymmetry in Xenopus.
Unilateral expression of Xnr-1 in the left lateral plate mesoderm directs the orientation of the left-right axis by driving the left-specific gene cascade.
asymmetric expression of Nodal-related 1 (Xnr1) begins in the posterior left lateral plate mesoderm shortly after the initiation of bilateral perinotochordal expression in the posterior tailbud
Xnr1 and derriere (show GDF3 Antibodies) are coexpressed in the posterior paraxial mesoderm at neurula stage, and with Coco (show DAND5 Antibodies) define a posttranscriptionally regulated signaling center in the chain leading to an increased TGF-beta (show TGFB1 Antibodies) signal on the left side of the embryo.
The protein encoded by this gene is a member of the TGF-beta superfamily. Studies of the mouse counterpart suggested that this gene may be essential for mesoderm formation and subsequent organization of axial structures in early embryonic development.
nodal-related protein 1
, nodal homolog (mouse)
, nodal homolog
, Nodal protein
, nodal homolog-like
, early embryo mesoderm formation
, transgenic lethal 413.d
, Nodal homolog 4
, nodal homolog 4-A
, nodal-related protein 4-A
, nodal-related 1, induction of axial mesoderm