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Browse our Nodal Proteins (NODAL)

Full name:
Nodal Homolog (Mouse) Proteins (NODAL)
On are 3 Nodal Homolog (Mouse) (NODAL) Proteins from 1 different suppliers available. Additionally we are shipping Nodal Kits (5) and Nodal Antibodies (1) and many more products for this protein. A total of 11 Nodal products are currently listed.
HTX5, nodal, nodal4, nodal4-A, nr1, nr1-A, nr4, Tg.413d, Xnr-1, xnr4
list all proteins Gene Name GeneID UniProt
Rat NODAL NODAL 294503  
Mouse NODAL NODAL 18119 P43021
Human NODAL NODAL 4838 Q96S42

Show all synonyms

More Proteins for Nodal Interaction Partners

Cow (Bovine) Nodal Homolog (Mouse) (NODAL) interaction partners

Mouse (Murine) Nodal Homolog (Mouse) (NODAL) interaction partners

  1. results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty (show LEFTY2 Proteins)-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A (show DNMT3A Proteins) and DNMT3B (show DNMT3B Proteins); findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation (show HELLS Proteins) and demethylation crucial to regulation of key signalling pathways in early body plan formation

  2. Results indicate that microRNA miR (show MLXIP Proteins)-127 accelerates mesendoderm differentiation of embryonic stem cells through nodal signaling by targeting left-right determination factor 2 (Lefty2 (show LEFTY2 Proteins)).

  3. The finding that Foxh1 (show FOXH1 Proteins)-Grg (show AES Proteins)-mediated repression is not essential for Nodal expression during mouse embryogenesis suggests that other regulators compensate for the loss of repressive regulatory input that is mediated by Grg (show AES Proteins) interactions.

  4. The Nodal morphogen (show SHH Proteins) gradient induces distinct gene expression patterns during zebrafish embryogenesis.

  5. HEB is a fundamental link between Nodal signalling, the derepression of a specific class of poised promoters during differentiation, and lineage specification in mouse embryonic stem cells

  6. Studies indicate that the pair of Nodal and Lefty (Lefty1 and Lefty2 (show LEFTY2 Proteins)) has a conserved role in left-right asymmetry.

  7. Studies indicate that Nodal/Smad2 (show SMAD2 Proteins)-dependent signals govern initial proximal-distal polarity and formation of the anterior visceral endoderm (AVE).

  8. Meteorin (show METRN Proteins) is a novel regulator of Nodal transcription

  9. This implies that Gdf1 (show GDF1 Proteins) potentiates Nodal activity by stabilizing a low molecular weight fraction that is susceptible to neutralization by soluble Acvr2 (show ACVR2A Proteins).

  10. The consequent prolonged Nodal activity in the node by the absence of Cerl2 (show DAND5 Proteins) affects local Nodal expression and prolongs its expression in the lateral plate mesoderm.

Human Nodal Homolog (Mouse) (NODAL) interaction partners

  1. patients with tumors in which both Nodal and YAP1 (show YAP1 Proteins) were expressed at high levels had the worst prognosis

  2. The MSX2 controls mesendoderm lineage commitment by simultaneous suppression of SOX2 (show SOX2 Proteins) and induction of NODAL expression through direct binding and activation of the Nodal promoter.

  3. During a maturation phase, a fast acting NODAL loop stimulates its own activity and temporarily inhibits BMP signaling. During the stabilization phase, a slow acting NODAL loop, involving WNTs re-establishes BMP signaling and the pluripotency circuitry.

  4. Nodal signaling pathway has subtle changes in the endometrium of women with endometriosis, but this imbalance may not cause functional damage as it seems not to affect the nuclear expression of SMAD4 (show SMAD4 Proteins).

  5. The expression of lefty (show LEFTY2 Proteins) in RCC (show XRCC1 Proteins) cells was lower than that in adjacent non-tumor cells, which may result in the overexpression of nodal, thereby promoting the growth of RCC (show XRCC1 Proteins).

  6. Nodal induces signal transduction through the Smad2 (show SMAD2 Proteins)/3-dependent pathway in vitro. Results that Nodal promotes pancreatic cancer cell migration and invasion and induces epithelial-mesenchymal transition.

  7. we found that Kl treatment impairs Nodal mRNA expression and Fgf9-mediated Nanos2 (show NANOS2 Proteins) induction, reinforcing the antagonistic effect of these two growth factors on the meiotic fate of male germ cells

  8. our studies provide mechanistic insights into Nodal signaling and Nodal inhibition with Cerberus (show CER1 Proteins) and highlight the potential value of Cerberus (show CER1 Proteins) as anti-Nodal therapeutic.

  9. Lefty reduced the levels of phosphorylated Smad2, Smad3, and ERK1/2, inhibited the proliferation and invasion of glioma cells, and increased their apoptosis.

  10. The data suggest that ERK (show EPHB2 Proteins) activation by Nodal signaling regulates c-myc (show MYC Proteins) and p27 (show PAK2 Proteins) proteins post-translationally and that this cascade is essential for aggressive breast tumor behavior in vivo.

Xenopus laevis Nodal Homolog (Mouse) (NODAL) interaction partners

  1. Data show taht combined Wnt (show WNT2 Proteins) and Nodal signaling synergistically activates transcription of Spemann organizer genes.

  2. Data suggest that Coco (show DAND5 Proteins) acts as a critical target of flow, suggesting that symmetry is broken by flow-mediated left-asymmetric release of Nodal repression at the midline.

  3. Data show that rapid differential transport of Nodal and Lefty (show LEFTY2 Proteins) on sulfated (show SULF1 Proteins) proteoglycan (show Vcan Proteins)-rich extracellular matrix regulates left-right asymmetry in Xenopus.

  4. Unilateral expression of Xnr-1 in the left lateral plate mesoderm directs the orientation of the left-right axis by driving the left-specific gene cascade.

  5. asymmetric expression of Nodal-related 1 (Xnr1) begins in the posterior left lateral plate mesoderm shortly after the initiation of bilateral perinotochordal expression in the posterior tailbud

  6. Xnr1 and derriere (show GDF3 Proteins) are coexpressed in the posterior paraxial mesoderm at neurula stage, and with Coco (show DAND5 Proteins) define a posttranscriptionally regulated signaling center in the chain leading to an increased TGF-beta (show TGFB1 Proteins) signal on the left side of the embryo.

Nodal (NODAL) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the TGF-beta superfamily. Studies of the mouse counterpart suggested that this gene may be essential for mesoderm formation and subsequent organization of axial structures in early embryonic development.

Alternative names and synonyms associated with Nodal (NODAL)

  • nodal growth differentiation factor (Nodal)
  • nodal homolog (mouse) (NODAL)
  • nodal (Nodal)
  • nodal growth differentiation factor (NODAL)
  • nodal growth differentiation factor (nodal)
  • nodal homolog 1 (nodal1)
  • HTX5 protein
  • nodal protein
  • nodal4 protein
  • nodal4-A protein
  • nr1 protein
  • nr1-A protein
  • nr4 protein
  • Tg.413d protein
  • Xnr-1 protein
  • xnr4 protein

Protein level used designations for Nodal Homolog (Mouse) Proteins (NODAL)

nodal-related protein 1 , nodal homolog (mouse) , nodal homolog , Nodal protein , nodal homolog-like , early embryo mesoderm formation , transgenic lethal 413.d , Nodal homolog 4 , Xnr-4 , nodal homolog 4-A , nodal-related protein 4-A , nodal-related 1, induction of axial mesoderm , nr-1 , xnr1

294503 Rattus norvegicus
395205 Gallus gallus
466100 Pan troglodytes
489028 Canis lupus familiaris
530748 Bos taurus
710424 Macaca mulatta
780406 Sus scrofa
100406643 Callithrix jacchus
100453474 Pongo abelii
100588745 Nomascus leucogenys
18119 Mus musculus
4838 Homo sapiens
398068 Xenopus laevis
378543 Xenopus laevis
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