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Browse our PPARGC1A (PPARGC1A) ELISA Kits

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Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha ELISA Kits (PPARGC1A)
On www.antibodies-online.com are 2 Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A) ELISA Kits from 2 different suppliers available. A total of 2 PPARGC1A products are currently listed.
Synonyms:
A830037N07Rik, AVPGC-1ALPHA, ENSMUSG00000079510, Gm11133, LEM6, PGC-1, PGC-1(alpha), Pgc-1alpha, PGC-1v, PGC1, PGC1A, Pgco1, Ppargc1, PPARGC1A
list all ELISA KIts Gene Name GeneID UniProt
PPARGC1A 19017 O70343
PPARGC1A 10891 Q9UBK2
Rat PPARGC1A PPARGC1A 83516 Q9QYK2

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PPARGC1A (PPARGC1A) ELISA Kits by Reactivity

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More ELISA Kits for PPARGC1A Interaction Partners

Mouse (Murine) Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A) interaction partners

  1. that PGC1alpha activates an oestrogen-related receptor alpha (ERRalpha (show ESRRA ELISA Kits))-dependent transcriptional program to elicit a catabolic state and metastasis suppression

  2. PGC-1alpha is a master metabolic sensor that regulates the expression of Vegfa (show VEGFA ELISA Kits) and Vegfb (show VEGFB ELISA Kits), coordinates blood vessels growth and fatty acid uptake with mitochondrial fatty acid oxidation.

  3. Chronic low-dose administration of MPTP (show PTPN2 ELISA Kits), which did not cause significant toxic effects in light of the relatively unaltered dopamine levels, did not result in any significant change of PGC-1alpha expression. Elevation of PGC-1alpha levels following acute treatment may be a short-term compensatory mechanism against mitochondrial damage induced by the complex I inhibitor MPTP (show PTPN2 ELISA Kits).

  4. Based on these findings, this study showed that CTRP9 (show C1QTNF9 ELISA Kits) might induce mitochondrial biogenesis and protect high glucose-induced endothelial oxidative damage via AdipoR1 (show ADIPOR1 ELISA Kits)-SIRT1 (show SIRT1 ELISA Kits)-PGC-1alpha signaling pathway.

  5. Metformin induced both the expression of PGC (show PGC ELISA Kits)-1a and an augmentation of its activity, as demonstrated by the increased expression of target genes, strongly promoting mitochondrial biogenesis. Furthermore, metformin enhanced oxygen consumption, ATP production, and overall mitochondrial activity. Most interestingly, this treatment reversed the fragmentation of mitochondria observed in Down syndrome

  6. PGC-1alpha may facilitate the addition of new myonuclei in order to reach myonuclear domain volumes that can support an increased mitochondrial density.

  7. FGF21 (show FGF21 ELISA Kits) promotes myoblast differentiation and serves as a switch of molecular transformation from anaerobic myofibers to aerobic myofibers via the FGF21 (show FGF21 ELISA Kits)-SIRT1 (show SIRT1 ELISA Kits)-AMPK (show PRKAA1 ELISA Kits)-PGC1alpha axis.

  8. The aim of the present study was to identify whether conjugated linolenic acid alters the expression of any of the peroxisome proliferator-activated receptor gamma (show PPARG ELISA Kits) coactivator 1alpha (PGC1alpha) isoforms, and to evaluate the possible existence of fibre-type-specific hypertrophy in the gastrocnemius and plantaris muscles.

  9. Different PGC-1alpha variants can affect target gene splicing through diverse mechanisms, including alternative promoter usage. By analyzing the exon structure of the target transcripts for each PGC-1alpha isoform, we were able to identify a large number of previously unknown PGC (show PGC ELISA Kits)-1alpha2 and -alpha3 target genes and pathways in skeletal muscle.

  10. Besides demonstrating remarkable similarities in the lesion profile of KSS and PGC (show PGC ELISA Kits)-1a-deficient mice, this study first provides morphological evidence for the identical origin of white matter

Pig (Porcine) Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A) interaction partners

  1. Transcription of the gene was detected in adipose, muscle, kidney, liver, brain, heart and adrenal gland tissues, which is in agreement with the function of PPARGC1A in adaptive thermogenesis.

  2. The purpose of this study was to screen for new single nucleotide polymorphisms in exon 8 of the porcine PPARGC1A gene and to test their possible association with production traits.

  3. impact of PPARGC1A on energy and lipid metabolism in vivo, through several downstream target genes

  4. The *2690T>C and *2864T>C polymorphisms in PPARGC1A can be used as genetic markers for selection toward improved meat quality.

  5. The c.-2894G>A polymorphism in the 5' upstream region of the porcine PPARGC1A gene can be used as a meaningful molecular marker for simultaneous improvement of lean meat production and quality traits.

  6. PPARGC1A may play a key role in down-regulating lipid deposition, and the SNPs with differential genotype distribution among three breeds may be related to gene expression and fat deposition.

  7. Polymorphisms in PPARGC1A and CAPNS1 (show CAPNS1 ELISA Kits) genes may affect meat quality traits.

Human Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A) interaction partners

  1. that PGC1alpha activates an oestrogen-related receptor alpha (ERRalpha (show ESRRA ELISA Kits))-dependent transcriptional program to elicit a catabolic state and metastasis suppression

  2. Review the most recent progress on PGC-1alpha and discuss its regulatory network in major glucose metabolic tissues such as the liver, skeletal muscle, pancreas and kidney. The significant associations between PGC-1alpha polymorphisms and type 2 diabetes mellitus are also discussed. Review.

  3. PGC-1alpha overexpression improves AngII-induced eNOS (show NOS3 ELISA Kits) dysfunction via activated PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) pathway, impaired PP2A (show PPP2R4 ELISA Kits) activity and reduced PP2A (show PPP2R4 ELISA Kits)-A/eNOS (show NOS3 ELISA Kits) association.

  4. HO-1 (show HMOX1 ELISA Kits)-derived CO enhances mitochondrial biogenesis in astrocytes by activating L-type Ca(2 (show CA2 ELISA Kits)+) channel-mediated PGC-1alpha/ERRalpha (show ESRRA ELISA Kits) axis, leading to maintenance of astrocyte function and neuroprotection/recovery against damage of brain function

  5. Decreased PPARGC1A gene expression in muscle has previously been associated with abnormal insulin (show INS ELISA Kits) function and may thus contribute to the increased risk of metabolic disease in O-GDM. The unaltered PPARGC1A gene expression in muscle of O-T1D suggests that factors other than intrauterine hyperglycemia may contribute to the decreased PPARGC1A expression in O-GDM.

  6. PGC-1alpha is associated with endothelial function in hypoxia-induced pulmonary arterial hypertension and that improved endothelial function is associated with improved cellular mitochondrial respiration, reduced inflammation and oxygen stress, and increased PGC-1alpha expression.

  7. There were also no statistically significant associations observed for the meta-analysis of the Polynesian populations between body mass index, or gout affection, or type 2 diabetes status and the Gly482Ser variant of PPARGC1A under any of the modes of genetic action.

  8. PPARGC1A association with essential tremor.

  9. Down-regulations of cell survival and EMT (show ITK ELISA Kits) were oberved in OVCAR-3 cells through suppression of PGC-1alpha by AEPP treatment. These results were confirmed through PGC-1alpha knockdown and overexpression in OVCAR-3 cells

  10. peroxisome proliferator-activated receptor gamma coactivator-1 alpha acts as a tumor suppressor in the formation and development of hepatocellular carcinoma.

Cow (Bovine) Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A) interaction partners

  1. The PPARGC1A synonymous mutation c.396G>A significantly associated with body weight and average daily gain in Nanyang cattle at the adult age.

  2. PPARGC1A genotypes had a significant effect on lengths of calving interval and calving to conception interval, and the T allele was demonstrated to have an unfavourable effect on these traits.

  3. NO/protein kinase (show CDK7 ELISA Kits) G (PKG (show PRKG1 ELISA Kits))-dependent downregulation of PGC-1 alpha and the ROS (show ROS1 ELISA Kits) detoxification system in endothelial cells are mediated by the PI3K/Akt (show AKT1 ELISA Kits) signaling

  4. The effects of dietary fat components on the expression of PPAR-gamma (show PPARG ELISA Kits) AND PPAR-gamma coactivator 1 in cultured bovine preadipocytes are reported.

  5. genetic analysis of bovine PPARGC1A

  6. PPARGC1A was associated with a significant increase in milk protein (show CSN2 ELISA Kits) percentage in contrast to association results previously reported for the German Holstein population

PPARGC1A Antigen Profile

Antigen Summary

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.

Alternative names and synonyms associated with PPARGC1A

  • peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A) Elisa Kit
  • peroxisome proliferative activated receptor, gamma, coactivator 1 alpha (Ppargc1a) Elisa Kit
  • peroxisome proliferator activated receptor gamma, coactivator 1 alpha (PPARGC-1) Elisa Kit
  • peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (Ppargc1a) Elisa Kit
  • peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (ppargc1a) Elisa Kit
  • A830037N07Rik Elisa Kit
  • AVPGC-1ALPHA Elisa Kit
  • ENSMUSG00000079510 Elisa Kit
  • Gm11133 Elisa Kit
  • LEM6 Elisa Kit
  • PGC-1 Elisa Kit
  • PGC-1(alpha) Elisa Kit
  • Pgc-1alpha Elisa Kit
  • PGC-1v Elisa Kit
  • PGC1 Elisa Kit
  • PGC1A Elisa Kit
  • Pgco1 Elisa Kit
  • Ppargc1 Elisa Kit
  • PPARGC1A Elisa Kit

Protein level used designations for PPARGC1A

peroxisome proliferator-activated receptor gamma, coactivator 1 alpha , PPAR-gamma coactivator , peroxisome proliferator activated receptor gamma coactivator-1 , PGC-1-alpha , PPAR Gamma Coactivator-1 , PPAR gamma coactivator variant form , PPAR-gamma coactivator 1-alpha , PPARGC-1-alpha , Pgc-1alphaa , peroxisome proliferator-activated receptor gamma coactivator 1-alpha , L-PGC-1alpha , ligand effect modulator-6 , peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4 , peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext , peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a , peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5 , peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT , peroxisome proliferative activated receptor, gamma, coactivator 1 , peroxisome proliferator activated receptor gamma coactivator 1 alpha , PGC-1alpha , peroxisome proliferative activated receptor gamma coactivator 1 , peroxisome proliferative activated receptor, gamma, coactivator 1 alpha , proliferator-activated receptor gamma coactivator 1 alpha , peroxisome proliferative activated receptor, gamma, coactivator 1, alpha , peroxisome-proliferator-activated receptor-gamma co-activator-1

GENE ID SPECIES
443270 Ovis aries
19017 Mus musculus
397013 Sus scrofa
10891 Homo sapiens
479127 Canis lupus familiaris
338446 Bos taurus
83516 Rattus norvegicus
100462892 Xenopus laevis
422815 Gallus gallus
100349219 Oryctolagus cuniculus
100721512 Cavia porcellus
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