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findings indicate that exercise intensity affected autophagy markers differently in skeletal muscle and suggest that PGC-1alpha regulates both acute and exercise training-induced autophagy in skeletal muscle potentially in a PGC-1alpha isoform specific manner
EET-mediated increase in HO-1 (show HMOX1 ELISA Kits) levels require PGC-1alpha expression
This change in the cellular location of p53 (show TP53 ELISA Kits) alleviates the abrogation of PGC (show PGC ELISA Kits)-1a repression caused by nuclear p53 (show TP53 ELISA Kits), which may further increases PGC (show PGC ELISA Kits)-1a expression
Peroxisome proliferator-activated receptor gamma (show PPARG ELISA Kits) coactivator 1alpha (PGC-1alpha) exerts beneficial effects on muscle inflammation that might contribute to the therapeutic effects of elevated muscle PGC-1alpha in different models of muscle wasting.
Adult conditional PGC-1alpha knock-out mice show a significant loss of dopaminergic neurons th (show EPRS ELISA Kits)at is accompanied by a reduction of dopamine in the striatum. Study identifies also two brain-enriched isoforms of PGC-1alpha: PGC-1alpha1L (160 kDa) and PGC-1alpha1S (100 kDa).
The study propose that gluconeogenesis driven by NTPGC- 1a, along with PGC (show PGC ELISA Kits)-1a, contributes to the elevated blood glucose level in response to fasting.
Metagenomic analysis revealed direct correlation between PPARGC1A, SNAI1 (show SNAI1 ELISA Kits), and metastatic lung disease.
Destabilization of PGC1a is attributable to decreased p38 MAPK (show MAPK14 ELISA Kits) activation via diminished CaMKII (show CAMK2G ELISA Kits) signaling. Thus, we elucidate a pathway downstream of Ca(2 (show CA2 ELISA Kits)+)-mediated CaMKII (show CAMK2G ELISA Kits) activation that is dysfunctional in C3KO(Capn3 (show CAPN3 ELISA Kits) knock-out mice ) mice, leading to reduced transcription of genes involved in muscle adaptation
lncBATE10 can decoy Celf1 (show CELF1 ELISA Kits) from Pgc1alpha, thereby protecting Pgc1alpha mRNA from repression by Celf1 (show CELF1 ELISA Kits)
Since the R6/2 mice represent a 'truncated' huntingtin (Htt (show HTT ELISA Kits)) mouse model of Huntington's disease (HD), we tested the efficacy of bezafibrate in a 'full-length' Htt (show HTT ELISA Kits) mouse model, the BACHD mice. Bezafibrate treatment restored the impaired PPARg (show PPARG ELISA Kits), PPARd (show PPARD ELISA Kits), PGC (show PGC ELISA Kits)-1a signaling pathway, enhanced mitochondrial biogenesis and improved antioxidant defense in the striatum of BACHD mice
Study investigated the molecular basis of such effects focusing on a commonly studied polymorphism in pig Pgc1alpha, which changes a cysteine at position 430 (WT) of the protein to a serine (C430S); found that differential O-GlcNAcylation of Pgc1alpha regulates PCK1 (show PCK1 ELISA Kits) activity and this molecular mechanism could explain at least in part the epistatic interaction between both genes.
Transcription of the gene was detected in adipose, muscle, kidney, liver, brain, heart and adrenal gland tissues, which is in agreement with the function of PPARGC1A in adaptive thermogenesis.
The purpose of this study was to screen for new single nucleotide polymorphisms in exon 8 of the porcine PPARGC1A gene and to test their possible association with production traits.
impact of PPARGC1A on energy and lipid metabolism in vivo, through several downstream target genes
The *2690T>C and *2864T>C polymorphisms in PPARGC1A can be used as genetic markers for selection toward improved meat quality.
The c.-2894G>A polymorphism in the 5' upstream region of the porcine PPARGC1A gene can be used as a meaningful molecular marker for simultaneous improvement of lean meat production and quality traits.
PPARGC1A may play a key role in down-regulating lipid deposition, and the SNPs with differential genotype distribution among three breeds may be related to gene expression and fat deposition.
Polymorphisms in PPARGC1A and CAPNS1 (show CAPNS1 ELISA Kits) genes may affect meat quality traits.
these results indicate that targeting components of the PGC1alpha-ID2-TCF4 (show TCF4 ELISA Kits)-integrin signaling pathway may suppress melanoma metastasis, and suggest that early use of BRAFV600E inhibitors may have the potential to reduce metastasis.
PGC-1alpha protein was higher after HIHVT than after SIT (p < 0.05). Moreover, the AMPKpTHR172/AMPK (show PRKAA1 ELISA Kits) ratio increased at post after SIT (p < 0.05), whereas this effect was delayed after HIHVT as it increased after 3 h
There were no significant correlations between LRP130 (show LRPPRC ELISA Kits), SIRT3 (show SIRT3 ELISA Kits), or PGC-1alpha mRNA expression in response to acute sprint-interval training. Changes in protein expression of LRP130 (show LRPPRC ELISA Kits), SIRT3 (show SIRT3 ELISA Kits), and PGC-1alpha were positively correlated at several time points with large effect sizes, which suggest that the regulation of these proteins may be coordinated in human skeletal muscle.
Study found that in human Parkinson's disease postmortem tissue from the substantia nigra pars (show EPRS ELISA Kits) compacta, there is a reduction of PGC-1alpha isoforms and mitochondria markers.
type 2 diabetes mellitus is associated with decreased expression of PGC1alpha and UCP1 (show UCP1 ELISA Kits) mRNA in epicardial adipose tissue of patients with coronary artery disease.
These studies suggest SIRT1 (show SIRT1 ELISA Kits)/PGC-1alpha as underlying pathways contributing to AMD (show AMD1 ELISA Kits) pathophysiology.
Low-intensity endurance cycling exercise performed with blood flow restriction failed to increase PGC-1alpha expression to that commonly observed with endurance exercise. Isoform-specific postexercise increases in the alpha4 isoform along with Hif-1alpha and VEGF mRNA expression following higher intensity endurance exercise without blood flow restriction.
These results highlight the combined effects of Parkin (show PARK2 ELISA Kits) and PGC-1alpha in the maintenance of mitochondrial homeostasis in dopaminergic neurons. These two factors synergistically control the quality and function of mitochondria, which is important for the survival of neurons in Parkinson's disease.
PPARGC1A rs4235308 has no significant association with ALS.
PPARGC1A single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.
The PPARGC1A synonymous mutation c.396G>A significantly associated with body weight and average daily gain in Nanyang cattle at the adult age.
PPARGC1A genotypes had a significant effect on lengths of calving interval and calving to conception interval, and the T allele was demonstrated to have an unfavourable effect on these traits.
NO/protein kinase (show CDK7 ELISA Kits) G (PKG (show PRKG1 ELISA Kits))-dependent downregulation of PGC-1 alpha and the ROS (show ROS1 ELISA Kits) detoxification system in endothelial cells are mediated by the PI3K/Akt (show AKT1 ELISA Kits) signaling
The effects of dietary fat components on the expression of PPAR-gamma (show PPARG ELISA Kits) AND PPAR-gamma coactivator 1 in cultured bovine preadipocytes are reported.
genetic analysis of bovine PPARGC1A
PPARGC1A was associated with a significant increase in milk protein (show CSN2 ELISA Kits) percentage in contrast to association results previously reported for the German Holstein population
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
, PPAR-gamma coactivator
, peroxisome proliferator activated receptor gamma coactivator-1
, PPAR Gamma Coactivator-1
, PPAR gamma coactivator variant form
, PPAR-gamma coactivator 1-alpha
, peroxisome proliferator-activated receptor gamma coactivator 1-alpha
, ligand effect modulator-6
, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4
, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext
, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a
, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5
, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT
, peroxisome proliferative activated receptor, gamma, coactivator 1
, peroxisome proliferator activated receptor gamma coactivator 1 alpha
, peroxisome proliferative activated receptor gamma coactivator 1
, peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
, proliferator-activated receptor gamma coactivator 1 alpha
, peroxisome proliferative activated receptor, gamma, coactivator 1, alpha
, peroxisome-proliferator-activated receptor-gamma co-activator-1