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anti-Human RNF4 Antibodies:
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Human Polyclonal RNF4 Primary Antibody for EIA, WB - ABIN954575
Hu, Rodrigues, Tao, Baker, Miraglia, Orth, Lyons, Schultz, Wu: Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen. in Proceedings of the National Academy of Sciences of the United States of America 2010
Show all 4 references for ABIN954575
Combined effect of dynamic recruitment of RNF4 to KAP1 regulates the relative occupancy of 53BP1 and BRCA1 at double-strand break sites to direct DNA repair in a cell cycle-dependent manner.
c-Myc (show MYC Antibodies) is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1 (show PIAS1 Antibodies), SENP7 (show SENP7 Antibodies) and RNF4
Data show that RNF4 is a SUMO-targeted ubiquitin ligase that targets TRF2 (show TERF2 Antibodies) for ubiquitination.
novel insight into cross-talk between ubiquitin and SUMO and uncover USP11 (show USP11 Antibodies) and RNF4 as a balanced SUMO-targeted ubiquitin ligase/protease pair with a role in the DDR (show DDR1 Antibodies).
RNF4 negatively regulates NF-kappaB (show NFKB1 Antibodies) signaling by down-regulating TAB2 (show TAB2 Antibodies)
RNF4 enhances Ube2E1 (show UBE2E1 Antibodies) self-ubiquitination.
NMR spectroscopy and biochemical characterization reveal how RNF4 manipulates the conformation of the SUMO chain, thereby facilitating optimal delivery of the distal SUMO domain for ubiquitin transfer.
RecQ-like helicase BLM subcellular localization is regulated by SUMO-targeted ubiquitin ligase RNF4 in response to DNA damage, presumably to prevent illegitimate recombination events.
Cells lacking RNF4 exhibited interstrand cross-linker hypersensitivity. The gene encoding RNF4 was epistatic with the other genes encoding members of the FA/BRCA pathway.
RNF4 mediates ubiquitination and turnover of MeCP2 (show MECP2 Antibodies) and thus derepresses transcription from DNA methylation (show HELLS Antibodies).
This paper identifies a nucleosome-targeting motif within the RNF4 RING domain that can bind DNA and thereby enables RNF4 to selectively ubiquitinate nucleosomal histones.
fork collapse in Atr (show ATR Antibodies)-deleted cells is mediated through the combined effects the sumo targeted E3-ubiquitin ligase RNF4 and activation of the AURKA (show AURKA Antibodies)-PLK1 (show PLK1 Antibodies) pathway
Rnf4 controls protein localization at DNA damage sites by integrating SUMOylation and ubiquitylation events.
SUMO interacting motif is dispensable for PML (show PML Antibodies) SUMOylation and interaction with RNF4 but is required for efficient PML (show PML Antibodies) ubiquitination, recruitment of proteasome components within NBs (show NLRP2 Antibodies) and proteasome-dependent degradation of PML (show PML Antibodies) in response to AsO
Rnf4 deficiency is embryonic lethal with higher levels of methylation in genomic DNA. Mechanistic studies show that RNF4 interacts with and requires the base excision repair enzymes TDG (show TDG Antibodies) and APE1 (show APEX1 Antibodies) for active demethylation.
GC-rich (show RELB Antibodies) elements flanking the transcription start site govern activation
1.6- and 3.0-kb transcripts originate from the same promoter, encode for the same protein and differ in the 3' UTR (show UTS2R Antibodies).
RNF4 is a negative regulator of TRPS1 (show TRPS1 Antibodies) activity
results suggest a role for small nuclear ring finger protein(SNURF/RNF4) in fetal germ cell development as well as in oocyte and granulosa cell maturation in an estrogen- and gonadotropin-regulated fashion
Rnf4 possesses ubiquitin E3 ligase activity.
The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.
E3 ubiquitin ligase RNF4
, E3 ubiquitin-protein ligase RNF4
, small nuclear RING finger protein
, gene trap ROSA b-geo 8
, small nuclear ring finger protein
, RING finger protein 4