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Human Polyclonal SMARCA4 Primary Antibody for ChIP, ICC - ABIN4285245
Miyamoto, Pasque, Jullien, Gurdon: Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes. in Genes & development 2011
Show all 4 Pubmed References
Human Polyclonal SMARCA4 Primary Antibody for WB - ABIN686122
Chen, Han, Wei, Zhang, Shi, Duan, Li, Zhou, Pu, Zhang, Kang: SNORD76, a box C/D snoRNA, acts as a tumor suppressor in glioblastoma. in Scientific reports 2015
Human Monoclonal SMARCA4 Primary Antibody for ICC, IF - ABIN2668498
de la Serna, Ohkawa, Higashi, Dutta, Osias, Kommajosyula, Tachibana, Imbalzano: The microphthalmia-associated transcription factor requires SWI/SNF enzymes to activate melanocyte-specific genes. in The Journal of biological chemistry 2006
Human Monoclonal SMARCA4 Primary Antibody for ICC, IF - ABIN2668499
Ohkawa, Harada, Nakamura, Yoshimura, Tachibana: Production of a rat monoclonal antibody against Brg1. in Hybridoma (2005) 2009
The BRG1/SIRT1 (show SIRT1 Antibodies)/p53 (show TP53 Antibodies) signal axis is a novel mechanism of cell senescence in CRC (show CALR Antibodies).
BRG1 and SMARCAL1 (show SMARCAL1 Antibodies), members of the ATP-dependent chromatin remodelling family, are shown to co-regulate the transcription of DROSHA (show DROSHA Antibodies), DGCR8 (show DGCR8 Antibodies), and DICER (show DICER1 Antibodies) in response to double-strand DNA breaks.
BRG1 was significantly increased in hepatocellular carcinoma. Overexpression of BRG1 increases cell growth and invasiveness in HCC (show FAM126A Antibodies).
Case Report: SMARCA4 nonsense/frameshift mutations responsible for concomitant Coffin-Siris syndrome, microphthalmia and small-cell carcinoma of the ovary hypercalcaemic type.
i-motif structures in long cytosine-rich sequences found upstream of the promoter region of the SMARCA4 gene
Brg1 coordinates a genetic and epigenetic network that regulates the transcriptional program underlying the Shh (show SHH Antibodies)-type medulloblastoma development.
whole-genome transcriptome analysis revealed that BRG1 controls the expression of key elements of oncogenic pathways such as PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) and BCL2 (show BCL2 Antibodies), which offers a promising new combination therapy for high-risk Neuroblastoma (show ARHGEF16 Antibodies) (NB).
A breakdown in a BRCA/FANCD2 (show FANCD2 Antibodies)/BRG1/SNF (show SNRPA Antibodies)-DeltaNP63-mediated DNA repair and differentiation maintenance process in mammary epithelial cells may contribute to sporadic breast cancer development.
both ABCB1 (show ABCB1 Antibodies) upregulation and doxorubicin resistance caused by SMARCB1 (show SMARCB1 Antibodies) loss were dependent on the function of SMARCA4, a catalytic subunit of the SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) complex.
BRG1 participates in gene repression by interacting with H1.2 (show HIST1H1C Antibodies), facilitating its deposition and stabilizing nucleosome positioning around the transcription start site.
n keratinocytes, the promoter-enhancer anchoring regions in the gene-rich transcriptionally active TADs are enriched for the binding of chromatin architectural proteins CTCF (show CTCF Antibodies), Rad21 (show RAD21 Antibodies) and chromatin remodeler Brg1. In contrast to gene-rich TADs, gene-poor TADs show preferential spatial contacts with each other, do not contain active enhancers and show decreased binding of CTCF (show CTCF Antibodies), Rad21 (show RAD21 Antibodies) and Brg1 in keratinocytes
Data demonstrate that Brg1 plays an essential role in development and homeostasis, including morphogenesis, stem cell differentiation and cell survival in the duodenum.
Point mutations in SMARCA4 (also known as BRG1) mapping to the ATPase (show DNAH8 Antibodies) domain cause loss of direct binding between BAF (show BANF1 Antibodies) and PRC1 (show PRC1 Antibodies).
BRG1 promotes transcription of endothelial Mrtfa and Mrtfb, which elevates expression of SRF and SRF target genes that establish embryonic capillary integrity.
RB is necessary for the recruitment of the BRG1 ATPase (show DNAH8 Antibodies) to DNA double-strand breaks, which stimulates DNA end resection and homologous recombination
Cdx (show CDX1 Antibodies) members interact with the SWI (show SMARCA1 Antibodies)-SNF (show SNRPA Antibodies) complex and make direct contact with Brg1, a catalytic member of SWI (show SMARCA1 Antibodies)-SNF (show SNRPA Antibodies). Both Cdx2 (show CDX2 Antibodies) and Brg1 co-occupy a number of Cdx (show CDX1 Antibodies) target genes, and both factors are necessary for transcriptional regulation of such targets. Finally, Cdx2 (show CDX2 Antibodies) and Brg1 occupancy occurs coincident with chromatin remodeling at some of these loci.
BRG1/BRM (show SMARCA2 Antibodies) and c-MYC (show MYC Antibodies) have an antagonistic relationship regulating the expression of cardiac conduction genes that maintain contractility, which is reminiscent of their antagonistic roles as a tumor suppressor and oncogene (show RAB1A Antibodies) in cancer.
Results provide insights into the mechanisms by which Brg1 functions, which is in part via the p53 (show TP53 Antibodies) program, to constrain gene expression and facilitate rapid embryonic growth.
Brg1 promotes neurogenic radial glial progenitor cell specification but is dispensable for neuronal differentiation
SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) chromatin remodeler subunits Brg1 and Brm (show SMARCA2 Antibodies) are expressed differentially during drug-induced liver injury and regeneration in a mouse model.
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4
, transcription activator BRG1-like
, ATP-dependent helicase SMARCA4
, BRG1-associated factor 190A
, BRM/SWI2-related gene 1
, SNF2-like 4
, brahma protein-like 1
, global transcription activator homologous sequence
, homeotic gene regulator
, mitotic growth and transcription activator
, nuclear protein GRB1
, protein BRG-1
, protein brahma homolog 1
, sucrose nonfermenting-like 4
, transcription activator BRG1
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
, SWI/SNF related transcriptional activator
, WI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4