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Human Monoclonal TAF7 Primary Antibody for IF, IHC (p) - ABIN563086
DAlessio, Ng, Willenbring, Tjian: Core promoter recognition complex changes accompany liver development. in Proceedings of the National Academy of Sciences of the United States of America 2011
Show all 4 Pubmed References
TAF7 is essential for proliferation but not for proliferation-independent differentiation of T cells
upon transcription inhibition, binding of RNA polymerase II to gene regulatory elements is severely reduced. However, contacts between regulatory DNA elements and genes in the beta-globin (show HBB Antibodies) locus are unaffected
EAF1 (show SRCAP Antibodies) (239-268) and TAF7 (205-235) peptide interactions were both mapped to the same groove formed by H3 and H4 helices of MED26 (show MED26 Antibodies) N-terminal domain.
the MED26 (show MED26 Antibodies)-NTD functions as a molecular switch in the exchange of TBP-associated factor 7 (TAF7) for LEC to facilitate the transition from initiation to elongation during transcription of a subset of snRNA genes
These results resolve the structural organization of the TAF1 (show TAF1 Antibodies)-TAF7 module in TFIID (show TBP Antibodies) and unveil a critical promoter-binding function of TAF1 (show TAF1 Antibodies) in transcription regulation.
the surface of the TAF1 (show TAF1 Antibodies)-TAF7 complex contains two prominent conserved surface pockets, one of which binds selectively to an inhibitory trimethylated histone H3 (show HIST3H3 Antibodies)
three CTD kinases, CDK7 (show CDK7 Antibodies), CDK9 (show CDK9 Antibodies), and BRD4 (show BRD4 Antibodies), engage in cross-talk, modulating their subsequent C-terminal domain phosphorylation, and also phosphorylate TAF7
analysis of phosphorylation-dependent regulation of cyclin D1 (show CCND1 Antibodies) and cyclin A (show CCNA2 Antibodies) gene transcription by TFIID (show TBP Antibodies) subunits TAF1 (show TAF1 Antibodies) and TAF7
TAF7, until now considered only a TFIID (show TBP Antibodies) component and regulator of TAF1 (show TAF1 Antibodies)-dependent transcription, also regulates TAF1 (show TAF1 Antibodies)-independent transcription
TAF7 represents a novel c-Jun (show JUN Antibodies) co-activator mediating activation of AP-1 (show FOSB Antibodies) target genes in response to extracellular signals
TAF7 has a role as a basal regulator for mammalian polyamine transport activity and MGBG-induced apoptosis
These results suggest normal TBP (show TBP Antibodies)-binding interactions--specifically recognition, stability, and conformation-are disrupted by CldAMP insertion into eukaryotic promoter sequences.
The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II.
, TBP-associated factor
, TBP-associated factor 55kD
, transcription initiation factor tfiid 55 kDa subunit
, transcription initiation factor TFIID subunit 7
, RNA polymerase II TBP-associated factor subunit F
, TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55 kDa
, TATA box binding protein (TBP) associated factor, RNA polymerase II, F, 55 kDa
, transcription initiation factor TFIID 55 kDa subunit
, TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
, TATA-binding protein associated factor 7
, TATA box binding protein (TBP)-associated factor, RNA polymerase II, F, 55kD
, TBP-associated factor F
, transcription factor IID subunit TAFII55
, transcription initiation factor TFIID, 55 kDa subunit
, TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa