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|Antigen||Cardiotrophin 1 (CTF1) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This Cardiotrophin 1 antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-Cardiotrophin 1 AntibodyTarget Details Cardiotrophin 1 Application Details Handling Images
|Specificity||This antibody detects endogenous levels of Cardiotrophin-1 protein. (region surrounding His31)|
Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
|Purity||> 95 % by SDS-PAGE|
Target Details Cardiotrophin 1Product Details anti-Cardiotrophin 1 Antibody Application Details Handling Images back to top
|Alternative Name||Cardiotrophin-1 (CTF1 Antibody Abstract)|
|Background||Cardiotrophin-1 (CT-1) is a member of the IL-6 family of cytokines, which signal through gp130 receptor complexes. gp130 complexes with several different receptor subunits to transmit signals from Cardiotrophin-1, IL-6, LIF, OSM, CNTF and IL-11. Cardiotrophin-1 binds to and activates the leukemia inhibitory factor (LIF) receptor/gp130 receptor complex and has been shown to induce hypertrophy in cardiac myocytes in vitro. Cardiotrophin-1, a secreted protein expressed at high levels in myocardium during cardiogenesis, has been shown to promote proliferation and survival of embryonic cardiomyocytes, suggesting a role for Cardiotrophin-1 in the activation of gp130 during cardiac development. Cardiotrophin-1 is highly expressed in heart, prostate, ovary and skeletal muscle. Lower levels of expression are seen in lung, kidney, pancreas, thymus, testis and small intestine.Synonyms: CT-1, CTF1|
|Molecular Weight||approx. 21 kDa|
|Research Area||Growth Factors|
Application DetailsProduct Details anti-Cardiotrophin 1 Antibody Target Details Cardiotrophin 1 Handling Images back to top
Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Cardiotrophin 1 Antibody Target Details Cardiotrophin 1 Application Details Images back to top
|Buffer||Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
ImagesProduct Details anti-Cardiotrophin 1 Antibody Target Details Cardiotrophin 1 Application Details Handling back to top