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Mouse (Murine) Cardiotrophin 1 Protein expressed in Escherichia coli (E. coli) - ABIN2666474
Jiménez-González, Jaques, Rodríguez, Porciuncula, Principe, Abizanda, Iñiguez, Escalada, Salvador, Prósper, Halban, Barajas: Cardiotrophin 1 protects beta cells from apoptosis and prevents streptozotocin-induced diabetes in a mouse model. in Diabetologia 2013
Show all 5 references for ABIN2666474
Human Cardiotrophin 1 Protein expressed in Escherichia coli (E. coli) - ABIN2666452
Ichiki, Jougasaki, Setoguchi, Imamura, Nakashima, Matsuoka, Sonoda, Nakamura, Minagoe, Tei: Cardiotrophin-1 stimulates intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 in human aortic endothelial cells. in American journal of physiology. Heart and circulatory physiology 2008
Show all 5 references for ABIN2666452
a transcriptional factor, Myc-associated zinc finger protein (MAZ (show MAZ Proteins)), plays an important role in ADAM10 (show ADAM10 Proteins) transcription in response to CT-1 in neural stem/progenitor cells.
CT-1 was found to be associated with Tn-I, which is used to detect myocardial damage after OPCAB surgery. CT-1 may also be used to detect myocardial damage.
non-diabetic subjects who were overweight or obesity had significantly lower cardiotrophin-1 concentrations than those with normal weight, and both obesity and being overweight were inversely associated with cardiotrophin-1 levels.
This paper will review many aspects of CT-1 physiological role in several organs and discuss data for consideration in therapeutic approaches.
biliary epithelium-derived CT-1 may exert a profibrogenic potential in PCLD (show PRKCSH Proteins).
Data show that cardiotrophin-1 is positively related to brachial-ankle pulse-wave velocity (baPWV) independent of traditional cardiometabolic risk factors for arterial stiffness.
this study, even though preliminary and awaiting further confirmation by independent replication, provides first evidence that common genetic variation in CTF1 could contribute to insulin (show INS Proteins) sensitivity in humans.
Study correlates CT-1 levels with ambulatory and central BP, as well as with pulse wave velocity in patients with essential hypertension.
CT-1 is differentially induced in the myocardium of infants with congenital cardiac defects depending on hypoxemia, and may mediate myocardial hypertrophy and dysfunction.
Subjects with impaired glucose tolerance (IGT) and newly diagnosed diabetes (NDD (show NDD Proteins)) have significantly higher CT-1 concentrations than those with normal glucose tolerance. IGT and NDD (show NDD Proteins) are positively associated with CT-1 concentrations.
Nuclear translocation of CT-1 regulates cardiomyogenesis of ES cells and involves calcium, NO, ROS (show ROS1 Proteins) as well as CT-1 regulated signaling pathways.
Data suggest that Ctf1 up-regulates lipolysis in white adipocytes via 1) induction of perilipin (show PLIN1 Proteins), 2) activation of hormone sensitive lipase (show LIPE Proteins) (via phosphorylation by PKA), and 3) inactivation of adipose triglyceride lipase (show PNPLA2 Proteins) (via up-regulation of G0S2 (show G0S2 Proteins)).
Cardiotrophin-1 (CT-1) is a hepatoprotective cytokine that modulates fat and glucose metabolism. Here we analyzed the changes in hepatic fat stores induced by recombinant CT-1 and its therapeutic potential in non-alcoholic fatty liver disease.
The transgenic expression of CTF1 brought about a marked improvement on cognitive functioning in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease.
CT-1 improves beta cell function and survival, and protects mice against STZ-induced diabetes
CT-1 may be a major regulator of arterial stiffness with a major impact on the aging process.
Hypoxia increased cardiotrophin-1 levels in cardiac cells through a direct regulation of CT-1 promoter by HIF-1alpha (show HIF1A Proteins), protecting cells from apoptosis.
Data suggest a key role for CT-1 in cardiac remodeling induced by aldosterone independent of changes in blood pressure levels.
We conclude that CT-1 is a master regulator of fat and glucose metabolism with potential applications for treatment of obesity and insulin (show INS Proteins) resistance.
Treatment of embryoid bodies grown from pluripotent murine embryonic stem (ES) cells with cardiotrophin 1 significantly stimulated cardiomyogenesis and increased nuclear expression of the proliferation marker Ki-67 (show MKI67 Proteins).
CT1 (show SLC6A8 Proteins) decreases cell death through a mechanism related to Stat3 (show STAT3 Proteins) and Akt (show AKT1 Proteins) phosphorylation and activation of calpastatin (show CAST Proteins) in D-galactosamine-treated hepatocytes.
The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene.
, cardiophin 1