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|Application / Reactivity||Mouse (Murine)||Human|
|Western Blotting (WB)||26 Antibodies||33 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||3 Antibodies||1 Antibodies|
|Immunohistochemistry (IHC)||11 Antibodies||4 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||2 Antibodies||2 Antibodies|
|Immunocytochemistry (ICC)||1 Antibodies|
|Flow Cytometry (FACS)||1 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies|
|ELISA||16 Antibodies||20 Antibodies|
|Antigen||Ciliary Neurotrophic Factor Receptor (CNTFR) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This CNTF Receptor alpha antibody is un-conjugated Alternatives|
Western Blotting (WB)
|1 reference available|
|Supplier||Log in to see|
Product Details anti-CNTF Receptor alpha AntibodyTarget Details CNTF Receptor alpha Application Details Handling References for anti-CNTF Receptor alpha Antibody (ABIN967627) Images
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Please refer to us for technical protocols.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
Target Details CNTF Receptor alphaProduct Details anti-CNTF Receptor alpha Antibody Application Details Handling References for anti-CNTF Receptor alpha Antibody (ABIN967627) Images back to top
|Alternative Name||CNTFRalpha (CNTFR Antibody Abstract)|
|Background||Ciliary neurotrophic factor receptor (CNTFR) shares functional and structural properties with members of the hematopoietic cytokine family. Signaling through the CNTFR involves the binding and activation of a multisubunit receptor complex composed of three components: a ligand-specific-alpha-receptor (CNTFRalpha), signal-transducing beta-subunits of gp130 and leukemia inhibitory factor receptor-beta (LIFR). Binding of CNTF to CNTFR triggers the association of the receptor complex components resulting in activation of a signal transduction cascade mediated by intracellular protein tyrosine kinases. CNTFR can function in a membrane-bound or soluble form, the membrane-bound form is expressed in neuronal and muscle cells, while the soluble form, once processed, can serve as a cofactor to potentiate CNTF actions. This action may serve to enhance the survival, proliferation, and maturation of oligodendrocyte lineage cells. AN-H6 recognizes human and mouse CNTFRalpha. The antibody is routinely tested by western blot analysis on L929 cells transfected with CNTFRalpha. The 40 and 60 kDa proteins are thought to represent the non-glycosylated and glycosylated forms of the CNTFRalpha, respectively.|
|Molecular Weight||50-60 kDa|
Application DetailsProduct Details anti-CNTF Receptor alpha Antibody Target Details CNTF Receptor alpha Handling References for anti-CNTF Receptor alpha Antibody (ABIN967627) Images back to top
Related Products: ABIN967389
|Restrictions||For Research Use only|
HandlingProduct Details anti-CNTF Receptor alpha Antibody Target Details CNTF Receptor alpha Application Details References for anti-CNTF Receptor alpha Antibody (ABIN967627) Images back to top
|Buffer||Aqueous buffered solution containing ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at 4°C.|
References for anti-CNTF Receptor alpha Antibody (ABIN967627)Product Details anti-CNTF Receptor alpha Antibody Target Details CNTF Receptor alpha Application Details Handling Images back to top
|Product cited in:||
Krüttgen, Grötzinger, Kurapkat et al.: "Human ciliary neurotrophic factor: a structure-function analysis." in: The Biochemical journal, Vol. 309 ( Pt 1), pp. 215-20, 1995 (PubMed).
ImagesProduct Details anti-CNTF Receptor alpha Antibody Target Details CNTF Receptor alpha Application Details Handling References for anti-CNTF Receptor alpha Antibody (ABIN967627) back to top