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Human EPOR Protein expressed in Human Cells - ABIN2003291
Jones, DAndrea, Haines, Wong: Human erythropoietin receptor: cloning, expression, and biologic characterization. in Blood 1990
Show all 6 references for ABIN2003291
Mouse (Murine) EPOR Protein expressed in Baculovirus infected Insect Cells - ABIN2007189
Yoshimura, Arai: Physician Education: The Erythropoietin Receptor and Signal Transduction. in The oncologist 1999
Show all 5 references for ABIN2007189
Mouse (Murine) EPOR Protein expressed in Human Cells - ABIN2007190
Liboi, Carroll, DAndrea, Mathey-Prevot: Erythropoietin receptor signals both proliferation and erythroid-specific differentiation. in Proceedings of the National Academy of Sciences of the United States of America 1994
Show all 5 references for ABIN2007190
These results identify EPOR as the secondbona fidehydroxylation-dependent substrate of VHL (show VHL Proteins) that potentially influences oxygen homeostasis and contributes to the complex genotype-phenotype correlation in VHL (show VHL Proteins) disease.
We report for a first time that functional EpoR is expressed in human rhabdomyosarcoma cell lines as well as by primary tumors from RMS patients.
erythrocyte lineage enforces exclusivity through upregulation of EKLF (show KLF1 Proteins) and its lineage-specific cytokine receptor (show EBI3 Proteins) (EpoR) while inhibiting both FLI-1 (show FLI1 Proteins) and the receptor TpoR (show MPL Proteins) (also known as MPL (show MPL Proteins)) for the opposing megakaryocyte lineage
A new point mutation in EPOR induces a short deletion in congenital erythrocytosis.
Data show that erythropoietin receptor antagonist EMP9 suppressed hemoglobin synthesis in xenografts of HeLa cells.
Data suggest that erythropoietin receptor (EPOR) could be a target to overcome therapeutic resistance toward ionizing radiation or temozolomide.
basic mechanisms for hypoxia-inducible factor induction of EPO (show EPO Proteins) expression, and within erythroid progenitors EPOR engagement of canonical Janus kinase 2 (show JAK2 Proteins)/signal transducer and activator of transcription 5 (show STAT5A Proteins) (JAK2 (show JAK2 Proteins)/STAT5 (show STAT5A Proteins))
transmembrane domain and the juxtamembrane region of the erythropoietin receptor in micelles
while EPO (show EPO Proteins) can stimulate NO production, NO in turn can regulate EPOR expression in endothelial cells during hypoxia
The progressive increase of EPO (show EPO Proteins) and EpoR mRNA can already be observed during the fibrotic-cirrhotic development with a peak of expression rising at tumor formation.
A solution NMR study of the mouse erythropoietin receptor (mEpoR) comprising the transmembrane domain and the juxtamembrane regions reconstituted in dodecylphosphocholine (DPC) micelles.
These data indicate that EpoR signaling is associated with cardiac remodeling following chronic iron deficiency.
We propose that the CID (show CENPA Proteins)-dependent dimerization system combined with the EpoR intracellular domain and the Gata1 (show GATA1 Proteins) gene regulatory region generates a novel peroral strategy for the treatment of anemia.
EpoR and its activity are downstream effectors of Klotho (show KL Proteins) enabling it to function as a cytoprotective protein against oxidative injury.
Expression of EPOR in rod photoreceptors, Muller cells, and amacrine, horizontal, and ganglion cells of the peripheral retina is not required for the maturation, function, and survival of these cells in aging tissue.
Data indicate a Cbl (show CBL Proteins)/p85 (show ECM1 Proteins)/epsin-1 (show EPN1 Proteins) pathway in erythropoietin receptor (EpoR) endocytosis.
Data from knockout mice suggest that adipose tissue-specific disruption of EPO (show EPO Proteins) receptor does not alter adipose tissue expansion, adipocyte morphology, insulin (show INS Proteins) resistance, inflammation, or angiogenesis.
the EPO (show EPO Proteins)-EPOR system may play a role in glucose metabolism within adipocytes.
EPOR regulates transcriptome for primary progenitors, including Tnfr (show TNFRSF1A Proteins)-sf13c as a novel mediator of EPO (show EPO Proteins)-dependent erythroblast formation.
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.
, Erythropoietin receptor
, type I single-transmembrane cytokine receptor
, erythropoietin receptor-like