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|Antigen||FYN Oncogene Related To SRC, FGR, YES (FYN) Antibodies|
|Epitope||AA 1-132 Alternatives|
|Reactivity||Dog (Canine), Human, Rat (Rattus) Alternatives|
|Conjugate||This FYN antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
|4 references available|
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Product Details anti-FYN AntibodyTarget Details FYN Application Details Handling ProductDetails: References for anti-FYN antibody (ABIN967789) Images
|Cross-Reactivity||Dog (Canine), Rat (Rattus)|
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Immunogen||Human fyn aa. 1-132|
Target Details FYNProduct Details anti-FYN Antibody Application Details Handling ProductDetails: References for anti-FYN antibody (ABIN967789) Images back to top
|Alternative Name||Fyn (FYN Antibody Abstract)|
|Background||Stimulation of the T cell antigen receptor (TcR) results in protein tyrosine phosphorylation via non-receptor tyrosine kinases. The src-related p59[fyn] kinase is one such enzyme that associates with the TcR. Ligation of the TcR activates the protein kinase activity of p59[fyn] in various human T cells. Fyn interacts with the CD3-zeta chains through its N-terminal region. In turn, fyn binds other proteins through its SH2 and SH3 domains. These proteins (p82 and p116) may serve as substrates and/or mediators of fyn activity. A 72 kDa fyn-related protein binds to the TcR/CD3 complex in certain T cells. This protein, known as p72[fyn-R], is a variant of the fyn kinase and contains at least four novel Ser/Thr phosphorylation sites. These sites may make p72[fyn-R] less susceptible to the action of phosphatases than p59[fyn]. Like p59[fyn], p72[fyn-R] is constitutively associated with its receptor. The exact relationship between these two proteins is not yet clear. However, p72[fyn-R] immunoprecipitates with various antisera raised to either the N- or C-terminus of fyn. Similar to src and yes, fyn is highly expressed in brain. The localization of fyn in mouse brain and its interaction with myelin-associated glycoprotein (MAG) suggests that the fyn kinase has a role in the sensory network and in myelination during early stages of CNS formation.|
|Molecular Weight||59 kDa|
|Research Area||Cancer, Tyrosine Kinases, Alzheimer's Disease, Signaling|
|Pathways||JAK-STAT Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Activated T Cell Proliferation, Thromboxane A2 Receptor Signaling|
Application DetailsProduct Details anti-FYN Antibody Target Details FYN Handling ProductDetails: References for anti-FYN antibody (ABIN967789) Images back to top
Related Products: ABIN968537, ABIN967389
|Restrictions||For Research Use only|
HandlingProduct Details anti-FYN Antibody Target Details FYN Application Details ProductDetails: References for anti-FYN antibody (ABIN967789) Images back to top
|Buffer||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at -20° C.|
ProductDetails: References for anti-FYN antibody (ABIN967789)Product Details anti-FYN Antibody Target Details FYN Application Details Handling Images back to top
|Product cited in:||
Zeng, Si, Yu, Le, Ng, Teng, Ryan, Wang, Ponniah, Pallen: "PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration." in: The Journal of cell biology, Vol. 160, Issue 1, pp. 137-46, 2003
Feuillet, Semichon, Restouin, Harriague, Janzen, Magee, Collette, Bismuth: "The distinct capacity of Fyn and Lck to phosphorylate Sam68 in T cells is essentially governed by SH3/SH2-catalytic domain linker interactions." in: Oncogene, Vol. 21, Issue 47, pp. 7205-13, 2002
Derkinderen, Toutant, Kadaré, Ledent, Parmentier, Girault: "Dual role of Fyn in the regulation of FAK+6,7 by cannabinoids in hippocampus." in: The Journal of biological chemistry, Vol. 276, Issue 41, pp. 38289-96, 2001
Kawakami, Kawakami, Aaronson, Robbins: "Acquisition of transforming properties by FYN, a normal SRC-related human gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, Issue 11, pp. 3870-4, 1988
ImagesProduct Details anti-FYN Antibody Target Details FYN Application Details Handling ProductDetails: References for anti-FYN antibody (ABIN967789) back to top