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|Antigen||Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ) Antibodies|
|Epitope||AA 22-31 Alternatives|
|Reactivity||Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This GNAQ antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Western Blotting (WB)
|3 references available|
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Product Details anti-GNAQ AntibodyTarget Details GNAQ Application Details Handling ProductDetails: References for anti-GNAQ antibody (ABIN968914) Images
|Cross-Reactivity||Mouse (Murine), Rat (Rattus), Chicken, Dog (Canine)|
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Immunogen||Human Galphaq aa. 22-31|
Target Details GNAQProduct Details anti-GNAQ Antibody Application Details Handling ProductDetails: References for anti-GNAQ antibody (ABIN968914) Images back to top
|Alternative Name||Galpha q (GNAQ Antibody Abstract)|
|Background||The GTP binding regulatory proteins (G proteins) consist of three subunits: alpha, beta, and gamma. These heterotrimeric proteins function at membranes to relay signals from cell surface receptors to intracellular effectors. The alpha subunit is unique for each G protein and contains the site of GTP binding and hydrolysis, as well sites for receptor and effector interactions. The betagamma subunit complex interacts directly with receptors and the alpha subunit. The Galpha family includes four families: the Galphas family including Galphas , Galphao1f, and Galphat, the Galphai family including Galphai, Galphao, and Galphaz, the Galphaq/Galpha11 family and the Galpha12/13 family. The Galphaq protein is 88% homologus with Galpha11 and both are widely expressed. These G proteins activate phospholipase C proteins, which induce calcium signaling events. G protein coupled receptors (GPCRs) involved in regulating Wnt signaling activate Galphaq, phospholipase Cbeta, and induce calcium-dependent activation of calpain. These events promote beta-catenin nuclear export and proteolysis. Galphaq has also been implicated in metabotropic glutamate receptor signaling. Thus, Galphaq isoforms activate phospholipase C proteins in various G-protein coupled receptor pathways.|
|Molecular Weight||42 kDa|
|Pathways||JAK-STAT Signaling, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction|
Application DetailsProduct Details anti-GNAQ Antibody Target Details GNAQ Handling ProductDetails: References for anti-GNAQ antibody (ABIN968914) Images back to top
Related Products: ABIN968537, ABIN967389
|Restrictions||For Research Use only|
HandlingProduct Details anti-GNAQ Antibody Target Details GNAQ Application Details ProductDetails: References for anti-GNAQ antibody (ABIN968914) Images back to top
|Buffer||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at -20° C.|
ProductDetails: References for anti-GNAQ antibody (ABIN968914)Product Details anti-GNAQ Antibody Target Details GNAQ Application Details Handling Images back to top
|Product cited in:||
Dutt, Kjoller, Giel, Hall, Toksoz: "Activated Galphaq family members induce Rho GTPase activation and Rho-dependent actin filament assembly." in: FEBS letters, Vol. 531, Issue 3, pp. 565-9, 2002
Li, Iyengar: "Calpain as an effector of the Gq signaling pathway for inhibition of Wnt/beta -catenin-regulated cell proliferation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 20, pp. 13254-9, 2002
Strathmann, Simon: "G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 23, pp. 9113-7, 1991
ImagesProduct Details anti-GNAQ Antibody Target Details GNAQ Application Details Handling ProductDetails: References for anti-GNAQ antibody (ABIN968914) back to top