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According to the results obtained, no association between the analysed polymorphism of genes: 5HTR2A (T102C), SLC6A4 (5-HTTLPR (show SLC6A4 ELISA Kits)) and schizophrenia was found
5-HT(2) receptors are coupled to phospholipase C (show PLC ELISA Kits) in bovine ciliary epithelium.
analysis of eight bovine 5-HT receptor (show HTR7 ELISA Kits) subtypes in brain, abomasum, and intestine by real-time RT-PCR
caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A) receptors through their Rho/ROCK signaling.
Study showed that acute stress activates 5-HT2AR expression in the mouse cortex and this activation requires the immediate early (show JUN ELISA Kits) gene Egr3 (show EGR3 ELISA Kits)
Whole-brain mapping and pharmacological screening indicated that serotonin-2A receptor (Htr2a)-expressing cells in the central amygdala (CeA (show CEA ELISA Kits)) control both innate and learned freezing, but in opposing directions
Study showed increased expression in striatum membranes and decreased expression in frontal cortex membranes for both DRD2 (show DRD2 ELISA Kits) and Htr2a from heterozygous Reelin (show RELN ELISA Kits) mutant mice compared to wild-type
Hippocampal mRNA expression of Htr2a is decreased in serotonin deficient mice after early life stress.
Involvement of 5-HT2 receptors in the expression of withdrawal diarrhea in morphine-dependent mice
Elevated whole-blood 5HT (show DDC ELISA Kits) or hyperserotonemia is a consistent finding in approximately 30% of autistic spectrum disorder individuals.
5-HT1A (show HTR1A ELISA Kits) and 5-HT2A receptors are able to modulate each other functional activity by means of bilateral functional cross-talk.
impact of the 5-HT2A and the 5-HT1A receptor (show CC2D1A ELISA Kits) for different serotonin syndrome-like responses
Translational and ecological study involving constitutive Htr2a(-/-) knock-out mice and related SNPs in depressed patients suggests that a lower neurotransmission at the 5-HT2AR may favor the susceptibility and severity of major depressive disorder
The results highlight a likely role of the 5-HT2 receptors in allergic airways disease and suggest that 5-HT2 receptor agonists may represent an effective and novel small molecule-based therapy for asthma.
epistatic effects of 5HTR1A (show HTR1A ELISA Kits) and 5HTR2A genes on suicidal behaviour were not significant
human HTR2A gene spans ~66 kilobases and consists of 7, rather than 4 exons; Furthermore, the revised human HTR2A-AS1 gene spans ~474 kilobases and consists of 18, rather than 3 exons
results suggest that 5-HT signaling participates in regulation of overall islet hormone secretion in non- diabetic individuals and over-expression of HTR1D and HTR2A may either contribute to islet dysfunction in T2D
OSAHS group had significantly higher AA genotype and A allele frequencies in the A1438G polymorphisms of the 5-HTR (show F2R ELISA Kits) 2A gene, and had significantly higher frequencies of 10/10, 12/10 genotypes and the allele 10 of 5-HTT (show SLC6A4 ELISA Kits)-VNTR.
No significant association was found between SNPs in HTR1A (show HTR1A ELISA Kits) (rs6295), HTR2A (rs6311 and rs6313) and SLC6A4 (show SLC6A4 ELISA Kits) and response to escitalopram in patients with major depressive disorder
signal transduction pathways downstream of 5-HT6R are regulated by MAP1B, which might play a role in 5-HT6R-mediated signaling in the brain.
The widely replicated 102C > T polymorphism in the HTR2A gene showed a statistically significant drug-gene interaction with serotonin uptake inhibitors use.
The data on the distribution of allele and genotype frequencies of the HTR1A (show HTR1A ELISA Kits), HTR2A, and HTR1B (show HTR1B ELISA Kits) genes can be used to determine the associations of the identified markers with various forms of human aggressive behavior.
This study showed that there were no differences in allele frequencies for the STin2 VNTR, 5-HTR2a 102T/C, and 5-HTR2a 1438A/G polymorphisms.
Single marker association analyses between genotypes and aggression scores indicated a significant role of rs7322347 located in the HTR2A gene encoding serotonin receptor 2a both for males and females.
The 5-HT(2A) receptor subtype is sensitive to elevated stretch.
Early weaning results in less active behaviour, accompanied by lower 5-HT1A and higher 5-HT2A receptor mRNA expression in specific brain regions.
excitatory 5-HT(2A) and inhibitory 5-HT(7 (show HTR7 ELISA Kits)) are present in the uterus of non-pregnant pigs. Endogenous 5-HT (show DDC ELISA Kits) containing cells are mainly present in uterine glands of the pig
The 5-HT 2A receptor seem to be particularly involved in antigen-induced airway hyperresponsiveness(AI-AHR (show AHR ELISA Kits)) to ACh (show FGFR3 ELISA Kits) in guinea-pigs.
Cimbi-36 is the first agonist radioligand suitable for examination of 5-HT2A receptors in the cortical regions and of 5-HT2C (show HTR2C ELISA Kits) receptors in the choroid plexus of the primate brain.
found enrichment of serotonin receptor 2A mRNA in primary visual cortex (V1) and clear activity-dependent modulatory effects of 5-HT2A receptor agonists on responses of V1 neurons.
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
, 5-hydroxytryptamine receptor 2A
, serotonin receptor 2A
, 5-HT2A receptor
, 5-hydroxytryptamine 2 receptor
, 5-HT2 receptor
, serotonin 5-HT-2A receptor
, serotonin 5HT-2 receptor
, 5HT2A receptor
, 5-hydroxytryptamine (serotonin) receptor 2A
, serotonin 2 receptor