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anti-Rat (Rattus) IFNA4 Antibodies:
anti-Mouse (Murine) IFNA4 Antibodies:
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Human Polyclonal IFNA4 Primary Antibody for WB - ABIN1881446
Linnane, Beilharz, McMullen, Macreadie, Murphy, Nisbet, Novitski, Woodrow: Nucleotide sequence and expression in E. coli of a human interferon-alpha gene selected from a genomic library using synthetic oligonucleotides. in Biochemistry international 1984
Show all 3 references for 1881446
IFN regulatory factor-3 is a component of virus-induced factor which binds the virus responsive element VRE-A4 in the IFNA4 promotor
Preferential binding sites for interferon (show IFNA Antibodies) regulatory factors 3 and 7 involved in interferon (show IFNA Antibodies)-A gene transcription
Data describe the species specificity of IFN-alphas, the residues in murine IFN-alpha4 that preclude strong affinity interactions with human IFNAR1 (show IFNAR1 Antibodies) and 2, and residues in human IFN-alpha8 (show IFNa14 Antibodies) that resemble a receptor interactive domain in murine IFN-alpha4.
Activation of the Akt (show AKT1 Antibodies) pathway by the IFN receptors complements the function of IFN-activated JAK (show JAK3 Antibodies)-STAT (show STAT1 Antibodies) pathways, by allowing mRNA translation of IFN-stimulated genes and, ultimately, the induction of the biological effects of IFNs.
Heterozygous IFNA4 variants is a cause of impaired function and CD-susceptibility genes in Chinese individuals from multiple center based study.
Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest.
Produced by macrophages, IFN-alpha have antiviral protein kinase and an oligoadenylate synthetase.
interferon, alpha 4
, interferon alpha-4
, MuIFN-alpha 4
, interferon alpha family, gene 4
, IFN-alpha 4
, interferon-alpha 4
, interferon alpha-4B
, interferon alpha-76
, interferon alpha-M1