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Mouse (Murine) IFNA4 Protein expressed in Human Cells - ABIN2008143
Takaoka, Hayakawa, Yanai, Stoiber, Negishi, Kikuchi, Sasaki, Imai, Shibue, Honda, Taniguchi: Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence. in Nature 2003
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IFN regulatory factor-3 is a component of virus-induced factor which binds the virus responsive element VRE-A4 in the IFNA4 promotor
Preferential binding sites for interferon (show IFNA Proteins) regulatory factors 3 and 7 involved in interferon (show IFNA Proteins)-A gene transcription
Data describe the species specificity of IFN-alphas, the residues in murine IFN-alpha4 that preclude strong affinity interactions with human IFNAR1 (show IFNAR1 Proteins) and 2, and residues in human IFN-alpha8 (show IFNa14 Proteins) that resemble a receptor interactive domain in murine IFN-alpha4.
Activation of the Akt (show AKT1 Proteins) pathway by the IFN receptors complements the function of IFN-activated JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins) pathways, by allowing mRNA translation of IFN-stimulated genes and, ultimately, the induction of the biological effects of IFNs.
Heterozygous IFNA4 variants is a cause of impaired function and CD-susceptibility genes in Chinese individuals from multiple center based study.
Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest.
Produced by macrophages, IFN-alpha have antiviral protein kinase and an oligoadenylate synthetase.
interferon, alpha 4
, interferon alpha-4
, MuIFN-alpha 4
, interferon alpha family, gene 4
, IFN-alpha 4
, interferon-alpha 4
, interferon alpha-4B
, interferon alpha-76
, interferon alpha-M1