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anti-Cow (Bovine) IFNAR1 antibody for Immunohistochemistry (Frozen Sections)

Recommended IFNAR1 Antibody (supplied by: Log in to see )

Antigen
Interferon (Alpha, beta and Omega) Receptor 1 (IFNAR1) Antibodies
  • AVP
  • CD118
  • Ifar
  • IFN-alpha-REC
  • IFN-R-1
  • IFNAR
  • Ifnar
  • ifnar1
  • IFNAR1
  • IFNBR
  • IFRC
  • Ifrc
  • Infar
Epitope
pSer539, pSer535
22
17
13
13
11
10
9
8
8
8
5
4
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Non Human Primates, Rat (Rattus), Sheep (Ovine)
135
37
19
1
1
1
1
Host
Rabbit
107
33
22
Clonality
Polyclonal
Conjugate
This IFNAR1 antibody is un-conjugated
13
11
10
8
6
4
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
92
68
38
36
22
10
7
5
4
2
1
Supplier
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Catalog No. ABIN372660
$ 412.50
Plus shipping costs $45.00

Top referenced anti-IFNAR1 antibody for Immunohistochemistry (Frozen Sections)

Similar anti-IFNAR1 Antibodies

Application / Reactivity Human Rat (Rattus) Cow (Bovine) Dog (Canine) Mouse (Murine) Non Human Primates Sheep (Ovine)
Western Blotting (WB) 86 Antibodies 9 Antibodies 2 Antibodies 2 Antibodies 10 Antibodies 1 Antibodies 2 Antibodies
Immunoprecipitation (IP) 6 Antibodies 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 3 Antibodies 10 Antibodies 4 Antibodies
Immunohistochemistry (IHC) 3 Antibodies 31 Antibodies 1 Antibodies 1 Antibodies 5 Antibodies 1 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies

General

Antigen Interferon (Alpha, beta and Omega) Receptor 1 (IFNAR1) Antibodies
Epitope pSer539, pSer535
(22), (17), (13), (13), (11), (10), (9), (8), (8), (8), (5), (4), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Non Human Primates, Rat (Rattus), Sheep (Ovine)
(135), (37), (19), (1), (1), (1), (1)
Host Rabbit
(107), (33), (22)
Clonality
Polyclonal
Conjugate This IFNAR1 antibody is un-conjugated
(13), (11), (10), (8), (6), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(92), (68), (38), (36), (22), (10), (7), (5), (4), (2), (1)
Pubmed 4 references available
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Product Details anti-IFNAR1 Antibody

Target Details IFNAR1 Application Details Handling References for anti-IFNAR1 Antibody (ABIN372660) Images
Specificity This antibody is specific for the IFNAR1 protein phosphorylated at Ser535,539. Note: The Molecular Weight of the IFNAR1 varies with cell line (different levels of glycosylation) in 293 and HeLa Cells, the mature form is ~110-130k.
Cross-Reactivity (Details) Species reactivity (expected):Bovine, Canine, Human, Mouse, Sheep and non-Human Primates.
Species reactivity (tested):Rat.
Purification Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
Immunogen Phosphopeptide corresponding to amino acid residues surrounding the phospho- Ser535,539 of Human IFNAR1.
Isotype IgG

Target Details IFNAR1

Product Details anti-IFNAR1 Antibody Application Details Handling References for anti-IFNAR1 Antibody (ABIN372660) Images back to top
Antigen
Alternative Name IFNAR1 (IFNAR1 Antibody Abstract)
Background Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron, 2001, Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-α Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).Synonyms: CRF2-1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, IFN-R-1, IFN-alpha Receptor alpha, IFN-alpha/beta receptor 1, Interferon-alpha/beta receptor alpha chain, Type I interferon receptor 1
Gene ID 3454
NCBI Accession NP_000620
UniProt P17181
Research Area Chromatin and Nuclear Signaling, Innate Immunity, Cytokines
Pathways JAK-STAT Signaling

Application Details

Product Details anti-IFNAR1 Antibody Target Details IFNAR1 Handling References for anti-IFNAR1 Antibody (ABIN372660) Images back to top
Application Notes Western blot: 1/1000. Immunohistochemistry: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-IFNAR1 Antibody Target Details IFNAR1 Application Details References for anti-IFNAR1 Antibody (ABIN372660) Images back to top
Format Liquid
Buffer 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody undiluted (in aliquots) at-20 °C.

References for anti-IFNAR1 Antibody (ABIN372660)

Product Details anti-IFNAR1 Antibody Target Details IFNAR1 Application Details Handling Images back to top
Product cited in:

Bhattacharya, HuangFu, Liu, Veeranki, Baker, Koumenis, Diehl, Fuchs: "Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor." in: The Journal of biological chemistry, Vol. 285, Issue 4, pp. 2318-25, 2010

Background publications

Kumar, Tang, Ravindranath, Clark, Croze, Fuchs: "SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor." in: The EMBO journal, Vol. 22, Issue 20, pp. 5480-90, 2003

Kirkwood: "Cancer immunotherapy: the interferon-alpha experience." in: Seminars in oncology, Vol. 29, Issue 3 Suppl 7, pp. 18-26, 2002

Biron: "Interferons alpha and beta as immune regulators--a new look." in: Immunity, Vol. 14, Issue 6, pp. 661-4, 2001

Images

Product Details anti-IFNAR1 Antibody Target Details IFNAR1 Application Details Handling References for anti-IFNAR1 Antibody (ABIN372660) back to top
Supplier Images
 image for anti-IFNAR1 antibody (Interferon (Alpha, beta and Omega) Receptor 1) (pSer539) (ABIN372660) anti-Interferon (Alpha, beta and Omega) Receptor 1 (IFNAR1) (pSer535), (pSer539) antibody