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anti-Human IFNB1 antibody for Functional Studies

Recommended IFNB1 Antibody (supplied by: Log in to see )

Antigen
Interferon, beta 1, Fibroblast (IFNB1) Antibodies
  • IFB
  • Ifb
  • IFF
  • IFN-beta
  • IFN-R
  • IFN-R-2
  • IFNb
  • IFNB
  • Ifnb
  • IFNBR
Reactivity
Human
302
30
15
15
11
7
7
5
5
3
1
1
1
Host
Rabbit
191
158
10
6
6
4
4
Clonality
Polyclonal
Conjugate
This IFNB1 antibody is un-conjugated
32
27
14
8
5
5
4
4
4
4
4
4
4
4
4
4
4
4
4
4
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Functional Studies (Func), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
304
264
84
49
31
26
24
24
17
14
12
8
6
5
4
2
2
2
1
1
Supplier
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Catalog No. ABIN116507
$ 286.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008758766 ABIN318982 Func Sheep IgG Log in to see Polyclonal 5
0.0008758766 ABIN181770 EIA Func IHC (p) WB Rabbit Log in to see Polyclonal
0.0008758766 ABIN189789 Func FACS IHC (fro) ELISA FITC Mouse IgG1 Log in to see MMHB-3
0.0008758766 ABIN189791 Func ELISA WB Mouse IgG1 Log in to see MMHB-2
0.0008758766 ABIN189793 Func IHC (fro) IP ELISA WB Mouse IgG3 Log in to see MMHB-13
0.0008758766 ABIN189796 Func IHC (fro) IP ELISA WB Mouse IgG1 Log in to see MMHB-16
0.0008758766 ABIN189788 Func IHC (fro) IP ELISA WB Mouse IgG2a Log in to see MMHB-3
0.0008758766 ABIN189794 Func IHC (fro) IP ELISA WB Mouse IgG2b Log in to see MMHB-14
0.0008758766 ABIN189792 Func IHC (fro) IP ELISA WB Mouse IgG1 Log in to see MMHB-12
0.0008758766 ABIN189790 Func IHC (fro) IP ELISA WB Mouse IgG1 Log in to see MMHB-1
0.0008758766 ABIN189795 Func IHC (fro) IP ELISA WB Mouse IgG2a Log in to see MMHB-15
0.0008758766 ABIN2487634 Func Sheep IgG Log in to see Polyclonal
0.0008758766 ABIN2474127 Func Sheep IgG Log in to see Polyclonal 4
0.0008758766 ABIN298987 Func Sheep IgG Log in to see Polyclonal
0.0008758766 ABIN643192 Func Sheep Log in to see
0.0008758766 ABIN189834 Func IHC (fro) IP ELISA WB Sheep Log in to see Polyclonal
0.0008758766 ABIN189835 Func IHC (fro) IP ELISA WB Rabbit Log in to see Polyclonal

Top referenced anti-IFNB1 antibody for Functional Studies

Similar anti-IFNB1 Antibodies

Application / Reactivity Human
Blocking Antibody (Inhibition) 1 Antibodies
ELISA 217 Antibodies
ELISA (Capture) 2 Antibodies
ELISA (Detection) 2 Antibodies
Enzyme Immunoassay (EIA) 7 Antibodies
Flow Cytometry (FACS) 23 Antibodies
Functional Studies (Func) 18 Antibodies
Immunoassay (IA) 4 Antibodies
Immunochromatography (IC) 1 Antibodies
Immunocytochemistry (ICC) 4 Antibodies
Immunofluorescence (IF) 6 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 72 Antibodies
Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)) 1 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 12 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 22 Antibodies
Immunoprecipitation (IP) 36 Antibodies
Neutralization (Neut) 13 Antibodies
Western Blotting (WB) 259 Antibodies

General

Antigen Interferon, beta 1, Fibroblast (IFNB1) Antibodies
Reactivity Human
(302), (30), (15), (15), (11), (7), (7), (5), (5), (3), (1), (1), (1)
Host Rabbit
(191), (158), (10), (6), (6), (4), (4)
Clonality
Polyclonal
Conjugate This IFNB1 antibody is un-conjugated
(32), (27), (14), (8), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Functional Studies (Func), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(304), (264), (84), (49), (31), (26), (24), (24), (17), (14), (12), (8), (6), (5), (4), (2), (2), (2), (1), (1)
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Product Details anti-IFNB1 Antibody

Target Details IFNB1 Application Details Handling Images
Specificity This antibody detects Interferon-beta (IFN-beta).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Antigen Affinity Chromatography using immobilized IFN-beta matrix
Immunogen Highly purified (>98%) E.coli derived recombinant Human Inferferon beta

Target Details IFNB1

Product Details anti-IFNB1 Antibody Application Details Handling Images back to top
Antigen
Alternative Name IFNB / Interferon beta (IFNB1 Antibody Abstract)
Background The mammalian type I Inteferons (IFN1) are produced in response to viral infection and other inducers. They are divided into alpha and beta subtypes leukocytes and fibroblasts reactivity. The human IFN alphas are encoded by a family of at least 15 different genes, while IFN beta is the unique member of its subtype. There is approximately 50 % amino acid homology between the alpha and beta subtypes. Both IFN subtypes are pleiotropic cytokines and have a similar range of biological activities. Differences between alpha subtypes, and between IFN alpha and betas, are in potency and cell type specific activities. In particular, IFN beta elicits a markedly higher antiproliferation response in some cell types such as, embryonal carcinoma, melanoma and melanocytes than do IFN alphas. Higher potency of IFN beta in treatment of multiple sclerosis and certain cancers has been observed. Type I IFNs signal through binding to a common cell surface receptor. Two chains of the receptor, IFNAR1 and IFNAR2, have been identified. Both chains are necessary for function and in the absence of either there is neither high affinity binding nor biological activity. The intracellular portions of the receptor subunits are bound by tyrosine kinases, Jak1 and Tyk2, members of the Janus kinase family. Upon ligand binding these kinases are activated and phosphorylate members of the STAT family of transcription factors, as well as IFNAR1 and 2.Synonyms: Fibroblast interferon, IFB, IFN-beta, IFNB1
Gene ID 3456
NCBI Accession NP_002167
UniProt P01574
Pathways JAK-STAT Signaling

Application Details

Product Details anti-IFNB1 Antibody Target Details IFNB1 Handling Images back to top
Application Notes Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity ofHuman IFN-beta (1.0 ng/mL), a concentration of 0.015-0.025 μg/mL of this antibody isrequired. Indirect ELISA: To detect Human IFN-beta by Indirect ELISA (using 100 μL/well antibodysolution) a concentration of 0.5-2.0 μg/mL of this antibody is required. In conjunction with compatible secondary reagents, it allows the detection of at least
Restrictions For Research Use only

Handling

Product Details anti-IFNB1 Antibody Target Details IFNB1 Application Details Images back to top
Reconstitution Restore in sterile water to a concentration of 0.1-1.0 mg/mL.
Buffer PBS, pH 7.2 without preservatives
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing. Centrifuge vial before opening.
Storage 4 °C/-20 °C
Storage Comment Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.